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Local Anesthetic

Lidocaine Infusion for Pancreatic Cancer

Q: What medical symptoms is Lidocaine Hydrochloride regularly administered to alleviate?

Lidocaine Hydrochloride is commonly administered to reduce intra ocular pressure (IOP) and can also prove beneficial for treating nasal irritation, increased renal excretion of toxins, as well as sciatica.

Q: How many participants are currently involved in this clinical trial?

Affirmative. The clinical trial data available on clinicaltrials.gov confirms that the study, which originated on November 8th 2018, is currently recruiting patients. There needs to be 46 participants at one medical centre for this investigation to proceed.

Q: Are participants being actively recruited for this experiment?

The details available on clinicaltrials.gov suggest that this research is actively recruiting patients, with the initial posting taking place on November 8th 2018 and an update to the listing being made April 8th 2022.

Q: Has there been prior experimentation utilizing Lidocaine Hydrochloride?

At this moment, 211 clinical trials are being done to research the properties of Lidocaine Hydrochloride with 53 of those studies in their third phase. The vast majority of these tests take place near Duarte <a href="https://www.withpower.com/clinical-trials/california">California</a>, but 1461 different sites offer them worldwide.

Phase < 1

Recruiting

Led By Gina E. Votta-Velis, MD PhD

Research Sponsored by University of Illinois at Chicago

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patients diagnosed with resectable cancer, but upon initial phase of surgical exploration found to have metastatic disease

Has measurable disease, defined as at least 1 tumor that fulfills the criteria

Timeline

Screening 3 weeks

Treatment Varies

Follow Up outcomes will be evaluated perioperatively

Awards & highlights

Study Summary

This trial will investigate whether IV lidocaine affects the behavior of pancreatic CTCs.

Who is the study for?

This trial is for patients with pancreatic cancer that was initially thought to be removable but found to have spread at surgery. They may have had previous treatments like chemo. Participants must understand and sign a consent form, and their cancer should be measurable by certain medical criteria.Check my eligibility

What is being tested?

The study is testing the effects of IV lidocaine (a local anesthetic) on circulating tumor cells in patients undergoing robotic surgery for pancreatic cancer. It's a controlled experiment where neither doctors nor patients know who gets lidocaine or a saline placebo.See study design

What are the potential side effects?

While not specified here, common side effects of IV lidocaine can include dizziness, sleepiness, changes in blood pressure, numbness around the mouth, tingling sensations, or even seizures if given too much.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

My cancer was thought to be removable but was found to have spread during surgery.

Select...

I have at least one tumor that can be measured.

Select...

My pancreatic cancer is confirmed and can be surgically removed.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ perioperatively

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~perioperatively

This trial's timeline: 3 weeks for screening, Varies for treatment, and perioperatively for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Specimen outcome measure.

Upregulation or Downregulation of Gene Expression.

Secondary outcome measures

Specimen outcome measure

Side effects data

From 2021 Phase 1 & 2 trial • 26 Patients • NCT03254394

43%

Nausea

29%

Dizziness

21%

Headache

14%

Paresthesia

14%

Lightheadedness

Somnolence

Arrhythmia

Blurred vision

Itching

100%

80%

60%

40%

20%

Study treatment Arm

Lidocaine + FOLFOX

Placebo + FOLFOX

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Lidocaine HydrochlorideExperimental Treatment1 Intervention

The IV bolus and infusions of lidocaine to those patients assigned to the lidocaine group will be started in the operating room and will continue until 24 h later. The group receiving the lidocaine infusion will first be administered a 1.0 - 1.5 mg/kg loading infusion over 5 minutes followed by a 1.0 - 1.5 mg/kg/h infusion for 24 h

Group II: Saline Solution for InjectionPlacebo Group1 Intervention

The group receiving the saline infusion will be administered an equivalent volume of saline infused over 5 min followed by a saline infusion at the same flow rate as that used in the lidocaine group for 24 h (1.0 - 1.5 mg/kg/hr)

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Lidocaine Hydrochloride

2022

Completed Phase 4

~2200

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of Illinois at ChicagoLead Sponsor

608 Previous Clinical Trials

1,559,459 Total Patients Enrolled

Gina E. Votta-Velis, MD PhDPrincipal InvestigatorAssociate Professor

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What medical symptoms is Lidocaine Hydrochloride regularly administered to alleviate?

"Lidocaine Hydrochloride is commonly administered to reduce intra ocular pressure (IOP) and can also prove beneficial for treating nasal irritation, increased renal excretion of toxins, as well as sciatica."

Answered by AI

How many participants are currently involved in this clinical trial?

"Affirmative. The clinical trial data available on clinicaltrials.gov confirms that the study, which originated on November 8th 2018, is currently recruiting patients. There needs to be 46 participants at one medical centre for this investigation to proceed."

Answered by AI

Are participants being actively recruited for this experiment?

"The details available on clinicaltrials.gov suggest that this research is actively recruiting patients, with the initial posting taking place on November 8th 2018 and an update to the listing being made April 8th 2022."

Answered by AI

Has there been prior experimentation utilizing Lidocaine Hydrochloride?

"At this moment, 211 clinical trials are being done to research the properties of Lidocaine Hydrochloride with 53 of those studies in their third phase. The vast majority of these tests take place near Duarte California, but 1461 different sites offer them worldwide."

Answered by AI

Recent research and studies

Regional Anesthesia & Pain MedicineJournal

Impact of Perioperative Pain Management on Cancer Recurrence: An ASRA/ESRA Special Article

Missair, Andres, Juan Pablo Cata, Gina Votta-Velis, Mark Johnson, Alain Borgeat, Mohammed Tiouririne, Vijay Gottumukkala, et al.. 2019. “Impact of Perioperative Pain Management on Cancer Recurrence: An ASRA/ESRA Special Article”. Regional Anesthesia & Pain Medicine. BMJ. doi:10.1136/rapm-2018-000001.

Tumor BiologyJournal

Prognostic Value of Circulating Tumor Cells in Patients with Pancreatic Cancer: A Meta-analysis

Han, Lu, Wei Chen, and Qicheng Zhao. 2013. “Prognostic Value of Circulating Tumor Cells in Patients with Pancreatic Cancer: A Meta-analysis”. Tumor Biology. Springer Science and Business Media LLC. doi:10.1007/s13277-013-1327-5.

Annals of Surgical OncologyJournal

Potential Prophylactic Measures Against Postoperative Immunosuppression: Could They Reduce Recurrence Rates in Oncological Patients?

Shakhar, Guy, and Shamgar Ben-Eliyahu. 2003. “Potential Prophylactic Measures Against Postoperative Immunosuppression: Could They Reduce Recurrence Rates in Oncological Patients?”. Annals of Surgical Oncology. Springer Science and Business Media LLC. doi:10.1245/aso.2003.02.007.

European Journal of Surgical Oncology (EJSO)Journal