Cognitive decline is a long-term deterioration in cognitive function. In many cases, the cognitive functions may be less severely affected by the decline than the individuals would recognize. Older adults may experience cognitive decline, but it differs in degree according to age and gender.
Cognitive decline can be very treated with multifactorial interventions, such as medications, and many of them can prevent progression of cognitive decline. Cognitive decline does not cure but it can prolong life by preventing sudden death. There is still no known cure for cognitive decline but it can be delayed or prevented to reduce burden on the patient and family. The treatments mentioned below are not an exhaustive list, but they are effective as of now. To find more treatments for cognitive decline, a systematic review is in preparation.
Age is the single factor that most reliably predicted functional decline. The associations of APOE and P-PAR suggest that other genetic and environmental risk factors are probably involved. Given the strong associations with decline, this suggests that lifestyle and environmental factors could be of particular importance.
Both men and women have an increased risk for cognitive impairment as they age. Between age 65 and 85, 8.6% of men and 8.1% of women suffer cognitive decline in the form of mild cognitive impairment or dementia.
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In the present day, cognitively impaired adults often display signs of impaired executive functioning and impairments in memory that can be easily tracked in daily life. In the elderly, cognitive disorder is often associated with decline in cognitive status or decline in performance. As the cognitive functions can be assessed via cognitive testing, the risk of developing a dementia can be predicted.
In a recent study, findings of present study suggest that using FastACCTs in combination with some of known neuroimaging correlates of executive functions may be useful in detecting early cognitive decline in population at risk for dementias such as MCI and AD.
Clinical trials evaluating FACT-COG have been conducted and it is likely that the outcomes may be different when comparing patients to the general population as well as from trial itself. Better patient outcome in trials versus real-world settings may be the result of more thorough assessment of patients, and/or a consequence of better adherence to experimental therapy versus untreated patients.
While there are ongoing clinical trials for the prevention of Alzheimer's disease, there have not been any new medications developed for treating this devastating disorder. This could be because many patients with Alzheimer's disease have an abnormal buildup of beta-amyloid protein in their brain (a buildup of Amyloid-beta), which is implicated in and triggers the progression of the disease.
Fast automated cognitive test batteries are safe for routine clinical use, and clinicians can use them to detect subtle cognitive impairment in primary care. These automated tests were associated with good sensitivity but poor specificity. Their use may result in misdiagnosis but with potentially favourable repercussions on patient management.
Although it is [very difficult to study in its own right; one needs to compare the findings from multiple research in one region] [cites a recent cohort study that found no association between cognitive decline and infertility as well as a review from 2014 that found no association between cognitive decline and men's perceptions of their health]. There is still no evidence-based conclusion about the effectivity of any drug for treating [cognitive decline] after being told that you will lose your ability to think. Researchers have reported many conflicting findings because of different study population and [outcome measures], and so there is no one way to tackle [covid_19 in the brain].
The battery does not appear to be effective in detecting cognitive decline in healthy middle-aged adults, but it is likely to hold more promise as a screening tool in detecting early abnormalities before the clinical presentation of vascular dementia and/or mild cognitive impairment. [Power]