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Trial Phase
Trial Status
Paid Participation
173 Depression Trials near Massachusetts
Power is an online platform that helps thousands of Depression patients discover FDA-reviewed trials every day. Every trial we feature meets safety and ethical standards, giving patients an easy way to discover promising new treatments in the research stage.
Learn More About PowerMM120 for Depression
Trial Details
Key Eligibility Criteria
140 Participants Needed
Osavampator as an Adjunctive Treatment for Depression
Trial Details
Key Eligibility Criteria
200 Participants Needed
SEP-363856 for Major Depressive Disorder
Trial Details
Key Eligibility Criteria
900 Participants Needed
Psychedelic-Assisted Therapy for Treatment Resistant Depression
Trial Details
Key Eligibility Criteria
142 Participants Needed
ABX-002-2001 for Depression
Trial Details
Key Eligibility Criteria
230 Participants Needed
Osavampator as an Adjunctive Treatment for Depression
Trial Details
Key Eligibility Criteria
200 Participants Needed
Osavampator as an Adjunctive Treatment for Depression
Trial Details
Key Eligibility Criteria
200 Participants Needed
SP-624 for Depression
Trial Details
Key Eligibility Criteria
456 Participants Needed
Esketamine vs. Ketamine for Depression
Trial Details
Key Eligibility Criteria
400 Participants Needed
Psilocybin for Depression
Trial Details
Key Eligibility Criteria
20 Participants Needed
Azetukalner for Depression
Trial Details
Key Eligibility Criteria
450 Participants Needed
Solriamfetol for Depression
Trial Details
Key Eligibility Criteria
300 Participants Needed
NMRA-335140 for Depression
Trial Details
Key Eligibility Criteria
332 Participants Needed
NMRA-335140 for Depression
Trial Details
Key Eligibility Criteria
332 Participants Needed
NMRA-335140 for Depression
Trial Details
Key Eligibility Criteria
650 Participants Needed
Lumateperone for Major Depressive Disorder
Trial Details
Key Eligibility Criteria
470 Participants Needed
Psilocybin Analog for Depression
Trial Details
Key Eligibility Criteria
220 Participants Needed
Multiple Medications for Bipolar Depression
Trial Details
Key Eligibility Criteria
2726 Participants Needed
Ketamine + Esketamine for Depression
Trial Details
Key Eligibility Criteria
100 Participants Needed
Brexanolone for Depression in Perimenopausal Women
Trial Details
Key Eligibility Criteria
80 Participants Needed
Why Other Patients Applied
"I've experienced drug resistant MDD for 2 decades. I have had no success with CBT and medication, nor either alone. I had success once with TMS, about 5 sessions, in 2014. I have not had TMS since then."
"I had a serious spinal cord injury four years ago, and my entire life turned upside down. I lost everything including a 10 year relationship. I became handicapped and part of that handicap is a mental handicap or I just can’t seem to find my happiness anymore. I go to events where everybody’s laughing, smiling, dancing, and having a good time, and I seem to just sit there like a bump on log. It feels like my spirit is broken. I want to feel happiness and motivation for life again."
"I've been through a substance abuse program three times. Clearly, it's not working. I need to try something totally different and new to deal with my depression (plus alcohol usage) once and for all. I did some research on psilocybin and want to try."
"Tried Lexapro, Wellbutrin and another (forget which). Surgical accident destroyed my mental nerve and left me in chronic pain, depression, and anxiety. That was 15 years ago. Disabled and retired. I'm tired of this."
"I was first diagnosed with major depressive disorder and anxiety over twenty years ago. I have tried different medications. Had to come off medications due to pregnancies, and have worked through different side effects like weight gain, nausea, sleepiness, and the more severe where i have tried to claw my way out of my skin it itched so bad. I dont want other people to have to go through this and I wish I could be off of my medication for good but it just hasnt happened. IF something is out there to improve the life of an anxious and/or depressed person I'd like to be able to say I helped find it."
AXS-05 for Depression
Trial Details
Key Eligibility Criteria
350 Participants Needed
Ketamine-assisted Psychotherapy for Depression
Trial Details
Key Eligibility Criteria
10 Participants Needed
BI 1569912 for Depression
Trial Details
Key Eligibility Criteria
224 Participants Needed
Individualized TMS for Depression
Trial Details
Key Eligibility Criteria
40 Participants Needed
ABBT for Mental Health in LGBTQ+ Community
Trial Details
240 Participants Needed
Zelquistinel for Depression
Trial Details
Key Eligibility Criteria
164 Participants Needed
BHV-7000 for Depression
Trial Details
Key Eligibility Criteria
480 Participants Needed
Perampanel + Ketamine for Suicidal Thoughts
Trial Details
Key Eligibility Criteria
30 Participants Needed
Pregnenolone for Depression in HIV
Trial Details
Key Eligibility Criteria
120 Participants Needed
Centanafadine for Depression
Trial Details
Key Eligibility Criteria
336 Participants Needed
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Frequently Asked Questions
How much do Depression clinical trials in Massachusetts pay?
Each trial will compensate patients a different amount, but $50-100 for each visit is a fairly common range for Phase 2–4 trials (Phase 1 trials often pay substantially more). Further, most trials will cover the costs of a travel to-and-from the clinic.
How do Depression clinical trials in Massachusetts work?
After a researcher reviews your profile, they may choose to invite you in to a screening appointment, where they'll determine if you meet 100% of the eligibility requirements. If you do, you'll be sorted into one of the treatment groups, and receive your study drug. For some trials, there is a chance you'll receive a placebo. Across Depression trials in Massachusetts 30% of clinical trials have a placebo. Typically, you'll be required to check-in with the clinic every month or so. The average trial length in Massachusetts for Depression is 12 months.
How do I participate in a study as a "healthy volunteer"?
Not all studies recruit healthy volunteers: usually, Phase 1 studies do. Participating as a healthy volunteer means you will go to a research facility in Massachusetts several times over a few days or weeks to receive a dose of either the test treatment or a "placebo," which is a harmless substance that helps researchers compare results. You will have routine tests during these visits, and you'll be compensated for your time and travel, with the number of appointments and details varying by study.
What does the "phase" of a clinical trial mean?
The phase of a trial reveals what stage the drug is in to get approval for a specific condition. Phase 1 trials are the trials to collect safety data in humans. Phase 2 trials are those where the drug has some data showing safety in humans, but where further human data is needed on drug effectiveness. Phase 3 trials are in the final step before approval. The drug already has data showing both safety and effectiveness. As a general rule, Phase 3 trials are more promising than Phase 2, and Phase 2 trials are more promising than phase 1.
Do I need to be insured to participate in a Depression medical study in Massachusetts?
Clinical trials are almost always free to participants, and so do not require insurance. The only exception here are trials focused on cancer, because only a small part of the typical treatment plan is actually experimental. For these cancer trials, participants typically need insurance to cover all the non-experimental components.
What are the newest Depression clinical trials in Massachusetts?
Most recently, we added Online Intervention for Transgender Young Adults' Alcohol Use, Mindfulness-Based Therapy for Serious Mental Illness and Pramipexole vs Escitalopram for Depression in HIV to the Power online platform.
What do the "Power Preferred" and "SuperSite" badges mean?
We recognize research clinics with these awards when they are especially responsive to patients who apply through the Power online platform. SuperSite clinics are research sites recognized for a high standard of rapid and thorough follow-up with patient applicants. Meanwhile, Power Preferred clinics are the top 20 across the entire Power platform, recognized for their absolute top patient experience.
Which clinics have received Power Preferred and SuperSite awards recruiting for Depression trials in Massachusetts?
The Depression clinics in Massachusetts currently recognized as Power Preferred are: Adams Clinical in Watertown, Massachusetts Copley Clinical Research in Boston, Massachusetts Adams Clinical in Watertown, Massachusetts Copley Clinical in Boston, Massachusetts Boston Clinical Trials in Roslindale, Massachusetts Adams Clinical in Watertown, Massachusetts The Depression clinics in Massachusetts currently recognized as SuperSites are: Massachusetts General Hospital in Boston, Massachusetts
What are the current treatment options for depression?
Doctors use a stepped-care approach. First, most people try evidence-based talk therapy (such as CBT or interpersonal therapy), an antidepressant medicine (SSRIs are typical), or both, while also improving sleep, exercise and diet. If symptoms persist, the next “step” is to add or switch treatments—e.g., combining two medicines, adding lithium or an antipsychotic, or using brain-stimulation methods like transcranial magnetic stimulation or, for severe cases, electroconvulsive therapy; newer options such as esketamine nasal spray are reserved for treatment-resistant depression. Working with a clinician to review progress every few weeks and adjust the plan is key to finding the right mix.
When is depression considered severe?
Doctors call a depressive episode “severe” when almost all of the nine core symptoms are present at high intensity, the person’s daily life has largely shut down (can’t work, study, or manage self-care), or there are high-risk features like active suicidal thoughts, a recent attempt, or hallucinations/false beliefs. On common checklists this usually means a PHQ-9 score of 20 or higher, and it signals the need for urgent, comprehensive care—often a combination of medication, psychotherapy, and sometimes hospitalization. If you or someone you know reaches this point, treat it as an emergency and contact a mental-health professional or call/text 988 (USA) or your local crisis line right away.
Is it possible to never be depressed again?
Some people have a single episode of depression and stay well, but the risk of another episode is higher if you stop treatment too soon, have had several episodes before, or still have mild symptoms. You can greatly lower that risk by continuing the treatment that got you better for at least 6–12 months, learning relapse-prevention skills in CBT or mindfulness therapy, keeping regular sleep, exercise, and social routines, and checking in early with a professional if warning signs return. In short, there is no iron-clad guarantee you’ll never be depressed again, but staying on maintenance care and a healthy lifestyle makes long-term wellness much more likely.
What are the top 3 symptoms of depression?
Doctors look first for three core signs: 1) a low or hopeless mood that hangs around most of the day, nearly every day; 2) a marked loss of interest or pleasure in things you used to enjoy (called anhedonia); and 3) big changes in body energy—feeling drained, sleeping or eating far more or less than usual. If any of these have lasted two weeks or longer, it’s time to talk with a health professional, because other symptoms can pile on and treatment works best when started early.
Is depression a chemical imbalance?
No—depression can’t be pinned on one missing brain chemical. Research shows it arises from a mix of factors: how your brain circuits and several neurotransmitters work, your genes, long-term stress, and life circumstances all interact. Because causes differ from person to person, the most effective care is usually a combination of approaches—medication when needed, talking therapies, and lifestyle changes—worked out with your clinician.
How many people have untreatable depression?
Doctors call “untreatable” depression “treatment-resistant depression,” meaning the person has not improved after trying at least two suitable antidepressants. Large studies show this applies to roughly one-quarter to one-third of people with major depression—about 2–3 % of adults overall, or roughly 5–8 million U.S. adults in any given year. Importantly, many still respond to other options such as medication combinations, ketamine/esketamine, transcranial magnetic stimulation, or electroconvulsive therapy.
How to get out of deep depression?
Think of recovery as two tracks that run side-by-side. Track 1: get professional help right away—if you ever feel unsafe call 988 (or your local hotline), and with a clinician discuss proven treatments such as CBT, antidepressant medicine, and, when needed, newer options like ketamine, transcranial magnetic stimulation or electroconvulsive therapy. Track 2: reinforce the medical plan daily with mood-boosting basics—consistent exercise, regular sleep, balanced meals, limited alcohol or drugs, and time with supportive people—because these habits make the treatments work better and give you small, sustainable lifts while you heal.
Why is depression so hard to treat?
Depression is hard to treat because it isn’t a single disease—each person’s symptoms arise from a unique blend of brain chemistry, genetics, stress, medical issues, and life circumstances—so one-size-fits-all therapies rarely work. Without a blood test to guide choices, clinicians must try treatments sequentially, and roughly one-third of people need several steps or a combination of medication, talk therapy, lifestyle changes, or newer options like ketamine or magnetic stimulation before they feel well. The encouraging news is that persistence with a systematic plan and attention to sleep, exercise, and co-existing conditions allows most patients to eventually reach full recovery.
What are unhealthy coping mechanisms for depression?
Unhealthy coping means doing things that give quick relief but actually deepen depression—common examples include using alcohol or other drugs, overeating or not eating, oversleeping or endless screen-scrolling to avoid feelings, cutting or other self-harm, harsh self-talk and rumination, and withdrawing from friends or lashing out at them. These behaviors worsen mood, relationships, and safety; if you notice yourself relying on them, reach out to a trusted person or mental-health professional (or call your local crisis line) and ask about safer skills such as problem-solving steps, scheduled activity, or therapy.
Is it OK to have clinical depression?
Yes—having clinical depression isn’t a personal failing; it’s a common medical illness, and recognising it is the first step toward feeling better. What isn’t OK is to face it alone, because untreated depression can worsen and raise the risk of other problems, whereas most people improve with timely care such as talk therapy, medication, or a combination. If symptoms last more than two weeks or include thoughts of self-harm, book a visit with a primary-care doctor or mental-health professional and, in crisis, call 988 (U.S.) or your local emergency number—effective help and recovery are the norm when treatment is started.