Caffeine for Learning in Healthy Adults
(Caffeine-RAC Trial)
Trial Summary
What is the purpose of this trial?
This research study aims to determine whether and how caffeine intake affects learning process through reward feedback compared to placebo. The data acquired from this study would improve our understanding on the consequence and mechanism of caffeine intake in the aspect of learning process.Participants will perform a reinforcement learning task (i.e. Probabilistic Selection Task) and a motor inhibition task (i.e. Go/NoGo task) in a brain scan. The scan will be done with the Siemens Biograph mMR positron emission tomography (PET)/ magnetic resonance imaging (MRI) 3 Tesla scanner. The PET allows us to see the changes in the "reward signals" - dopamine - in the brain using a radioactive dye called \[11C\]Raclopride. The MRI, on the other hand, enables us to take detailed pictures of the brain activities during cognitive tasks using a high-powered magnet. Reviewing these pictures will help us understand the influence of caffeine on reward signals and brain activities during the learning process.
Eligibility Criteria
This trial is for healthy adults interested in how caffeine affects learning. Participants will do tasks during a brain scan to see changes in dopamine, which helps with reward signals. They must be eligible based on certain health criteria not specified here.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Washout
Participants undergo a 6-day ambulatory washout period abstaining from caffeine, alcohol, and drugs
Treatment
Participants receive either caffeine or placebo and undergo PET/fMRI scans to assess neurochemical and hemodynamic changes
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Caffeine
Find a Clinic Near You
Who Is Running the Clinical Trial?
Hsiao-Ying Wey
Lead Sponsor