← Back to Search

Proton Pump Inhibitor

High Dose Omeprazole for Pancreatic Cancer (OU202005AJ Trial)

Phase < 1
Recruiting
Led By Ajay Jain, MD
Research Sponsored by University of Oklahoma
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Newly diagnosed exocrine pancreatic cancer with pathology confirmed as adenocarcinoma
Patient is a candidate for surgical resection of pancreatic cancer
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 years
Awards & highlights

OU202005AJ Trial Summary

This trial is testing if a high dose of a common stomach acid drug is safe for people with a certain kind of cancer.

Who is the study for?
This trial is for adults diagnosed with a specific type of pancreatic cancer known as exocrine adenocarcinoma, who are fit enough for surgery. They must not be pregnant or breastfeeding and should have no major heart issues or conditions that affect medication absorption. A negative pregnancy test is required for women able to bear children.Check my eligibility
What is being tested?
The study aims to evaluate the safety and effects of high doses of Omeprazole in patients with exocrine pancreatic cancer. It will involve participants who may or may not have received chemotherapy before joining the trial.See study design
What are the potential side effects?
While the side effects aren't specified here, high doses of Omeprazole could potentially cause digestive disturbances, headaches, dizziness, skin reactions, and an increased risk for bone fractures or kidney problems.

OU202005AJ Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have been newly diagnosed with a specific type of pancreatic cancer.
Select...
I am eligible for surgery to remove pancreatic cancer.
Select...
I can take care of myself and am up and about more than half of the day.
Select...
I am not pregnant and either cannot become pregnant or have had a negative pregnancy test recently.
Select...
I am 18 years old or older.

OU202005AJ Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Proportion
Safety and Tolerability
Secondary outcome measures
Correlation
pH
v-ATPase LC3-I and LC3-II expression

OU202005AJ Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Arm A (High Dose)Experimental Treatment1 Intervention
Omeprazole, 80 mg, PO, BID for 2 weeks prior to surgical therapy of pancreatectomy. All 30 subjects in Arm A to be enrolled prior to Arm B cohort enrollment.
Group II: Arm B (Normal Dose)Placebo Group1 Intervention
Omeprazole, 20 mg, PO, QD for 2 weeks prior to surgical therapy of pancreatectomy.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Omeprazole
2006
Completed Phase 4
~940

Find a Location

Who is running the clinical trial?

University of OklahomaLead Sponsor
455 Previous Clinical Trials
97,553 Total Patients Enrolled
Ajay Jain, MDPrincipal InvestigatorUniversity of Oklahoma
2 Previous Clinical Trials
170 Total Patients Enrolled

Media Library

Omeprazole (Proton Pump Inhibitor) Clinical Trial Eligibility Overview. Trial Name: NCT04930991 — Phase < 1
Pancreatic Cancer Research Study Groups: Arm A (High Dose), Arm B (Normal Dose)
Pancreatic Cancer Clinical Trial 2023: Omeprazole Highlights & Side Effects. Trial Name: NCT04930991 — Phase < 1
Omeprazole (Proton Pump Inhibitor) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04930991 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Could I potentially qualify to participate in this research study?

"This clinical trial seeks to enrol roughly 60 individuals who have been diagnosed with pancreatic cancer and are between 18-99 years old."

Answered by AI

Is there presently an opportunity for individuals to take part in this clinical trial?

"Upon consulting clinicaltrials.gov, the trial appears to be in active recruitment mode with its initial post being made on September 7th 2021 and most recent update occurring on November 18th 2021."

Answered by AI

Have past experiments demonstrated the effectiveness of Omeprazole?

"As of present, 10 clinical trials for the drug Omeprazole are underway. None currently are in their third stage and Portland, Oregon is home to many of them but there are 50 other sites conducting research as well."

Answered by AI

Are octogenarians eligible for this experiment?

"Patients must be between 18 and 99 years old to qualify for this medical trial. Additionally, there are 13 trials that cater to minors and 585 studies for people 65 or older."

Answered by AI

What illnesses does Omeprazole typically aid in remedying?

"Omeprazole can be a useful treatment for such conditions as gastroesophageal reflux disease, heartburn, and the rare Zollinger-Ellison syndrome."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
High Dose Omeprazole in Patients With Pancreatic Cancer
2021. "High Dose Omeprazole in Patients With Pancreatic Cancer". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04930991.
~2 spots leftby Jun 2024
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top