Stereotactic Radiosurgery for Spinal Cord Compression

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Henry Ford Hospital, Detroit, MI
Spinal Cord Compression+6 More
Stereotactic Radiosurgery - Radiation
Eligibility
18+
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether a combination of spinal interstitial laser ablation and stereotactic spine radiosurgery is more effective than either treatment alone.

See full description

Eligible Conditions

  • Spinal Cord Compression
  • Spine Metastases
  • Spinal Cord Diseases
  • Neoplasm Metastasis
  • Spinal Cord Tumors

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Stereotactic Radiosurgery will improve 1 primary outcome, 6 secondary outcomes, and 3 other outcomes in patients with Spinal Cord Compression. Measurement will happen over the course of up to 24 months.

Month 24
Changes in symptoms assessed by physical examination
Month 24
Changes in symptoms assessed by neurological examination
Local Tumor Control
Postoperative response to treatment assessed by MRI
Month 24
Overall Survival
Month 24
Measuring Quality of life (QOL) assessed by Brief Pain Inventory Survey (BPI)
Measuring Quality of life (QOL) assessed by Health Survey (SF-36)
Measuring Quality of life (QOL) assessed by Spine Tumor Survey (MDASI-SP)
up to 24 months
Adverse Events
Local Tumor Control Rate

Trial Safety

Trial Design

1 Treatment Group

Experimental Treatment of Laser Interstitial Thermal Ablation Therapy and Stereo...
1 of 1
Experimental Treatment

This trial requires 60 total participants across 1 different treatment group

This trial involves a single treatment. Stereotactic Radiosurgery is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Experimental Treatment of Laser Interstitial Thermal Ablation Therapy and Stereotactic RadiosurgeryPatients will undergo laser interstitial thermal ablation and CT guided stereotactic radiosurgery via intensity-modulated radiation therapy on different dates within a one to fourteen day window. The order of treatment is at the treating physicians discretion.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Stereotactic Radiosurgery
2012
Completed Phase 2
~320

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 1, 3, 6, 9, 12, 18, and 24 months
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 1, 3, 6, 9, 12, 18, and 24 months for reporting.

Who is running the study

Principal Investigator
I. L.
Ian Lee, MD
Henry Ford Health System

Closest Location

Henry Ford Hospital - Detroit, MI

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 2 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
This technique is recommended for patients who are 18 years old or older show original
accompanying text) The doctor diagnosed a solid malignant tumor that is not one of the more radiosensitive histologic subtypes. show original

Patient Q&A Section

How quickly does cancer, second primary spread?

"The incubation period of cancers after first primary cancer is approximately 6 years. The speed of cancer progression is slow when compared to that of secondary cancer, but primary cancers tend to have longer incubation periods than secondary cancers. The incubation period of secondary cancers is shorter than that of primary cancers." - Anonymous Online Contributor

Unverified Answer

What is the survival rate for cancer, second primary?

"Cancer, second primary is an extremely rare occurrence, with only 0.2% of all cancers being secondary to another type of cancer. Survival is poor, with an average of 11 months between diagnosis of the initial tumor and diagnosis of the second tumor. The most common type of second secondary cancer is adenocarcinoma, usually presenting around 8 years later. A prospective cohort study would be required to ascertain the true incidence of cancer, second primary. However, the data suggested that it may be prudent to advise patients with a history of cancer to have regular screening examinations to detect any early signs of recurrence. If there is suspicion of a second primary, then a biopsy or resection of the suspected lesion should be performed." - Anonymous Online Contributor

Unverified Answer

What are the common side effects of stereotactic radiosurgery?

"Radiation therapy can produce many different side effects which resolve after a few treatments. The most common side effect is temporary double vision which usually resolves after a few weeks. Other side effects include bruising, fatigue, nausea, and pain around the site of injection. These side effects typically occur within the first week of treatment but may take up to 6 months to fully recover. All these side effects, however, rarely result in permanent damage to the eye." - Anonymous Online Contributor

Unverified Answer

Is stereotactic radiosurgery safe for people?

"SRS should only be considered in patients with a life expectancy of less than 10 years if they are medically fit and their tumours are small and localized." - Anonymous Online Contributor

Unverified Answer

Does stereotactic radiosurgery improve quality of life for those with cancer, second primary?

"The SF-36 scores were significantly improved after SRS compared with the baseline. In addition, the VAS pain scores and the global QOL scores also showed significant improvement after SRS. That these improvements were maintained for up to 1 year post-SRS suggests that SRS may provide relief from symptom burden in this patient population." - Anonymous Online Contributor

Unverified Answer

What is stereotactic radiosurgery?

"The most common complication is infection, which occurs in about 10% of patients treated with SRS. Good outcomes are expected from SRS. Radiation-induced vision problems and hearing loss occur rarely. SRS is less costly than surgery. Patient satisfaction is excellent; patients prefer it to surgery. SRS should be considered as first-line therapy when no other options are available for patients who are medically fit." - Anonymous Online Contributor

Unverified Answer

What are the latest developments in stereotactic radiosurgery for therapeutic use?

"Stereotactic radiosurgery is a safe and effective method of controlling intracranial tumors. Since 1999, we have been using this technique to treat patients with a variety of intracranial tumors; especially those who have undergone prior surgical resection or biopsy. We believe this technique will continue to be rapidly evolving because of advances in technology and better understanding of radiation dosimetry." - Anonymous Online Contributor

Unverified Answer

Can cancer, second primary be cured?

"Cancer, second primary accounts for about 10% of all newly diagnosed cancers in Australia. It is important to note that the incidence of second primary cancers is not increasing, but rather decreasing over time, although there appears to be no obvious trend in mortality rates. New approaches to research and prevention strategies need to be developed." - Anonymous Online Contributor

Unverified Answer

What are the signs of cancer, second primary?

"In a recent study, we found that baseline symptoms differed between patients with cancer, second primary and non-cancer, second primary. A patient's risk factors for developing a cancer, second primary also differ depending on the type of cancer. Such knowledge may aid in the early detection of cancer, second primary and potentially reduce mortality." - Anonymous Online Contributor

Unverified Answer

What does stereotactic radiosurgery usually treat?

"Stereotactic radiosurgery is effective in treating brain tumors and arteriovenous malformations. It is often used for other conditions such as pituitary adenoma, cavernous sinus meningioma, and operable intracranial metastases. It has been applied to spinal cord compression, multiple sclerosis, trigeminal neuralgia, arteriovenous malformations, and head and neck cancer. Despite widespread use of this procedure, there is little evidence regarding its efficacy and safety for most indications." - Anonymous Online Contributor

Unverified Answer

What is the latest research for cancer, second primary?

"The most recent research suggests that there may be a link between smoking and cancer. This is important because smoking has contributed to approximately 20 percent of all cancers worldwide. In fact, it is projected to become the leading cause of cancer deaths in the United States by 2050. Additionally, a minimal amount of cigarette smoke (10 to 15 cigarettes per day) has been shown to increase the risk of developing lung cancer. Therefore, there is an urgent need to educate the public and health professionals about the risks associated with tobacco products and how these products can contribute to cancer development. Another study showed that there was no correlation related to lung cancer and alcohol consumption. More research needs to be done to understand the relationship between smoking and cancer." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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