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Lithium for Parkinson's Disease

Phase 1 & 2
Waitlist Available
Research Sponsored by State University of New York at Buffalo
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up throughout 24 week study
Awards & highlights

Study Summary

This trial will investigate how taking lithium 20mg/day affects MRI scans and blood tests in 20 people with early-stage Parkinson's disease, compared to those who take a placebo.

Who is the study for?
This trial is for early-stage Parkinson's disease patients who haven't used lithium before and have no other neurological conditions. Participants should not be tobacco or THC users, must have stable PD medications for over a month, and cannot have any active medical issues that could affect the study.Check my eligibility
What is being tested?
The study is testing if a low dose of lithium (20mg/day) can impact MRI and blood biomarkers in Parkinson's disease compared to a placebo. It involves 20 participants with early-stage PD to see if there are any benefits.See study design
What are the potential side effects?
While not specified here, common side effects of lithium may include increased thirst, hand tremors, frequent urination, mild nausea or diarrhea; however individual experiences may vary.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~throughout 24 week study
This trial's timeline: 3 weeks for screening, Varies for treatment, and throughout 24 week study for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
MRI-derived free water (FW) levels.
Peripheral blood mononuclear cell (PBMC) nuclear receptor-related 1 protein (Nurr1) mRNA expression
Serum neurofilament light chain (NfL)
Secondary outcome measures
Fatigue Severity Scale
Geriatric Depression Scale-15
Insomnia Severity Index
+10 more
Other outcome measures
Adverse events

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: LithiumActive Control1 Intervention
Lithium: 10mg, 2x/day
Group II: PlaceboPlacebo Group1 Intervention
Identical capsules filled with cellulose: 10mg, 2x/day

Find a Location

Who is running the clinical trial?

State University of New York at BuffaloLead Sponsor
247 Previous Clinical Trials
49,512 Total Patients Enrolled
The Cure Parkinson's TrustUNKNOWN
2 Previous Clinical Trials
86 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the eligibility criteria for individuals seeking to participate in this clinical study?

"Individuals aged between 40 and 80 with a confirmed diagnosis of Parkinson's disease are eligible to participate in this trial, which aims to recruit approximately 20 participants."

Answered by AI

What are the objectives of this particular research endeavor?

"This research aims to evaluate changes in MRI-derived free water levels from baseline to the 24-week mark. Secondary objectives include assessing Parkinson's Anxiety Scale (score range: 0-48, higher scores signify poorer outcomes), Parkinson's disease Questionnaire-8 (score range: 0-32, higher scores indicate worse outcomes), and PBMC pS9/total glycogen synthase kinase-3B ratio through ELISA analysis."

Answered by AI

Are individuals above the age of 35 being sought for enrollment in this research study?

"To be eligible for enrollment in this research study, individuals must fall within the age range of 40 to 80 years. It is noteworthy that there are a total of 21 investigations focused on participants under 18 and 518 studies targeting those over the age of 65."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Repurposing Lithium for Parkinson's Disease: a RCT
Thomas Guttuso 2024. "Repurposing Lithium for Parkinson's Disease: a RCT". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06339034.
~13 spots leftby Aug 2025
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