Study Summary
This trial gives cancer patients astatine-211, a radioactive substance, before their donor stem cell transplant. The hope is that the astatine will kill the cancer cells while having less of an effect on the healthy cells.
- Acute Myeloid Leukemia (AML) arising from Myelodysplastic Syndrome (MDS)
- Acute Myeloid Leukemia
- Acute Lymphoblastic Leukemia (ALL)
- Recurrent Mixed Phenotype Acute Leukemia
- Refractory Acute Myelogenous Leukemia
- Mixed Phenotype Acute Leukemia
- Acute Recurrent Myeloid Leukemia
- Refractory Acute Lymphoblastic Leukemia
- Acute Lymphoblastic Leukemia
- Chronic Myelomonocytic Leukemia
- Myelodysplastic Syndrome With Excess Blasts (MDS-EB)
Treatment Effectiveness
Effectiveness Progress
Study Objectives
1 Primary · 8 Secondary · Reporting Duration: Up to 2 years
Trial Safety
Safety Progress
Trial Design
1 Treatment Group
Treatment (211^At-BC8-B10, PBSC)
1 of 1
Experimental Treatment
75 Total Participants · 1 Treatment Group
Primary Treatment: Cyclosporine · No Placebo Group · Phase 1 & 2
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 18 - 75 · All Participants · 10 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:- Li, Yawen, Donald K. Hamlin, Ming-Kuan Chyan, Roger Wong, Eric F. Dorman, Robert C. Emery, Douglas R. Woodle, et al.. 2018. “Cgmp Production of Astatine-211-labeled Anti-cd45 Antibodies for Use in Allogeneic Hematopoietic Cell Transplantation for Treatment of Advanced Hematopoietic Malignancies”. Edited by Michael Ernst-Heinrich Fassbender. Plos One. Public Library of Science (PLoS). doi:10.1371/journal.pone.0205135.
- 2017. "211^At-BC8-B10 Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome, or Mixed-Phenotype Acute Leukemia". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03128034.
Frequently Asked Questions
Are there any other scientific papers which have researched Cyclosporine?
"At this time, 599 clinical trials are underway that focus on cyclosporine. Of these, 58 are in phase 3. Many of the trials for cyclosporine are based in Philadelphia, Pennsylvania; however, there are 5940 locations running studies for this treatment across the globe." - Anonymous Online Contributor
Is this research project only testing people who are under 40 years old?
"The age requirements to participate in this study are between 18-75 years old." - Anonymous Online Contributor
How can I enroll in this research project?
"Eligibility requirements for this leukemia clinical trial include being between 18 and 75 years old. Myelomonocytic and chronic subtypes of the cancer are also admissible. A total of 50 patients are needed for recruitment." - Anonymous Online Contributor
Are investigators still looking for study participants?
"This study, which was originally posted on October 24th 2017, is still actively recruiting participants according to information found on clinicaltrials.gov. The listing was last updated on August 29th 2022." - Anonymous Online Contributor
How is Cyclosporine most often used to help patients?
"Cyclosporine is often used to treat lymphoma, non-hodgkin. Other potential benefits of taking cyclosporine include prevention of stem cell transplant rejection, interstitial cystitis treatment, and managing nephrotic syndrome." - Anonymous Online Contributor