Positive Airway Pressure for Usual Interstitial Pneumonia
Phase-Based Progress Estimates
Effectiveness
Safety
University of Arizona, Tucson, AZ
Usual Interstitial Pneumonia+7 More
Positive Airway Pressure - DeviceEligibility
18+
All Sexes
What conditions do you have?
Select
Eligibility
18+
All Sexes
What conditions do you have?
Select
Study Summary
This trial will study whether using CPAP to treat sleep apnea can improve symptoms in patients with idiopathic pulmonary fibrosis. Positive Airway Pressure is used to treat Usual Interstitial Pneumonia. Positive Airway Pressure has previously been approved by the FDA for a different condition. No patients in this trial will be given a placebo instead of the treatment.
Eligible Conditions
- Usual Interstitial Pneumonia
- Obstructive Sleep Apnea (OSA)
- Gastroesophageal Reflux
Treatment Effectiveness
Effectiveness Progress
Study Objectives
1 Primary · 9 Secondary · Reporting Duration: 6 months
4-8 weeks
24hr-Esophageal pH
Biomarker of Lung Inflammation: CXCL13
Biomarker of Lung Inflammation: IL-8
Biomarker of Lung Inflammation: KL-6
Biomarker of Lung Inflammation: MMP1
Biomarker of Lung Inflammation: MMP7
Composite Biomarker Score
Esophageal pH During Sleep
6 months
Composite Biomarker Score at Six Months
FVC change
Trial Safety
Safety Progress
Trial Design
2 Treatment Groups
No CPAP
1 of 2
CPAP
1 of 2
Active Control
Experimental Treatment
20 Total Participants · 2 Treatment Groups
Primary Treatment: Positive Airway Pressure · No Placebo Group · N/A
CPAP
Device
Experimental Group · 1 Intervention: Positive Airway Pressure · Intervention Types: DeviceNo CPAPNoIntervention Group · 1 Intervention: No CPAP · Intervention Types:
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Positive Airway Pressure
2009
N/A
~290
Trial Logistics
Trial Timeline
Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 6 months
Closest Location: University of Arizona · Tucson, AZ
2002First Recorded Clinical Trial
0 TrialsResearching Usual Interstitial Pneumonia
240 CompletedClinical Trials
Who is running the clinical trial?
University of ArizonaLead Sponsor
447 Previous Clinical Trials
153,961 Total Patients Enrolled
Boehringer IngelheimIndustry Sponsor
2,373 Previous Clinical Trials
9,768,327 Total Patients Enrolled
Sachin Chaudhary, MDPrincipal InvestigatorUniversity of Arizona
Eligibility Criteria
Age 18+ · All Participants · 7 Total Inclusion Criteria
Mark “yes” if the following statements are true for you:You have a confirmed diagnosis of IPF based on the 2018 IPF guidelines.
You have a high likelihood of OSA based on the STOP-BANG measure, with a score of 3 or greater.
You are able to comply with CPAP treatment.
You are willing to complete all study measurements and assessments in compliance with the protocol.
About The Reviewer
Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.
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