32 Participants Needed

Isolation Conditions for Stress and Resilience

MB
MC
Overseen ByMichele Carlin
Age: 18 - 65
Sex: Any
Trial Phase: Academic
Sponsor: University of Pennsylvania
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. However, if you have certain medical conditions or use substances like tobacco, you may not be eligible to participate.

How does the 8-day isolation treatment differ from other treatments for stress and resilience?

The 8-day isolation treatment is unique because it involves placing individuals in a confined space to study stress and resilience, unlike other treatments that might focus on medication or therapy. This approach allows researchers to directly observe the psychological and physiological effects of isolation, which can provide insights into stress management and resilience building.12345

What is the purpose of this trial?

This trial studies how people react to being in a space-like environment, including confinement, work, boredom, and isolation. It aims to find out who can handle the stress of long space missions. Researchers will measure body functions and behaviors to see how well people adapt to these conditions.

Research Team

DD

David Dinges, PhD

Principal Investigator

University of Pennsylvania

Eligibility Criteria

This trial is for English-speaking individuals aged 30-55 with a master's degree or equivalent in STEM or military experience, who are physically and mentally healthy with a BMI under 35. It excludes those with acute medical conditions, major psychiatric illnesses, substance abuse issues, certain cardiovascular/neurological problems, and specific MRI contraindications like metallic implants.

Inclusion Criteria

BMI < 35
I am between 30 and 55 years old.
I have a master's degree or equivalent in STEM or have served in the military.
See 2 more

Exclusion Criteria

You currently smoke or use tobacco products.
I do not have any severe ongoing illnesses, major psychiatric conditions, epilepsy, or thyroid disease.
Alcohol or drug abuse in the past year based upon history and urine toxicology screen
See 6 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Isolation and Confinement

Subjects will spend 7-night/8-day in an isolated and confined unit with up to 3 other subjects

8 days
Continuous stay in isolation unit

Follow-up

Participants are monitored for changes in resilience, stress, brain structure and function, sleep, biomarker response to stress, cognitive performance, and heart rate

1 week

Treatment Details

Interventions

  • 8-Days in an Isolation, Confinement Unit
Trial Overview The study involves spending 8 days in an isolation unit to assess how different people adapt to stress caused by confinement and isolation. It looks at biological and behavioral responses to understand resilience and well-being under these controlled but challenging conditions.
Participant Groups
1Treatment groups
Experimental Treatment
Group I: 8-Days in an Isolation, Confinement UnitExperimental Treatment1 Intervention
Subjects will spend 7-night/8-day in an isolated and confined unit with up to 3 other subjects.

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Pennsylvania

Lead Sponsor

Trials
2,118
Recruited
45,270,000+

University of Pittsburgh

Collaborator

Trials
1,820
Recruited
16,360,000+

National Aeronautics and Space Administration (NASA)

Collaborator

Trials
32
Recruited
1,900+

References

Experiences of supported isolation in returning travellers during the early COVID-19 response: a qualitative interview study. [2022]
The impact of long-term confinement and exercise on central and peripheral stress markers. [2015]
Mental health of individuals infected with SARS-CoV-2 during mandated isolation and compliance with recommendations-A population-based cohort study. [2022]
Effects of isolation, crowding, and different psychological countermeasures on crew behavior and performance. [2022]
COVID-19 Lockdown: Key Factors in Citizens' Stress. [2021]
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