Ketorolac for Postpartum preeclampsia

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Barnes Jewish Hospital, Saint Louis, MOPostpartum preeclampsia+1 MoreKetorolac - Drug
Eligibility
Any Age
Female
What conditions do you have?
Select

Study Summary

This trial tests if adding nonsteroidal anti-inflammatory drugs to preeclampsia treatment helps prevent postpartum hypertension.

Eligible Conditions
  • Postpartum preeclampsia
  • Pre-Eclampsia, Severe

Treatment Effectiveness

Study Objectives

1 Primary · 6 Secondary · Reporting Duration: at the end of hospitalization, up to 7 days after randomization

Week 6
Hospital readmission
Mean arterial blood pressure
Postpartum opioid use
Postpartum pain scores
Day 7
postpartum antihypertensive requirements
Day 4
End organ damage
up to 6 weeks
Continued anti-hypertensive requirement

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Trial Design

2 Treatment Groups

NSAID free analgesic bundle
1 of 2
NSAID Analgesic bundle
1 of 2

Active Control

Experimental Treatment

286 Total Participants · 2 Treatment Groups

Primary Treatment: Ketorolac · No Placebo Group · Phase 2

NSAID Analgesic bundleExperimental Group · 4 Interventions: Oxycodone, Ibuprofen 600 mg, Acetaminophen, Ketorolac · Intervention Types: Drug, Drug, Drug, Drug
NSAID free analgesic bundleActiveComparator Group · 2 Interventions: Oxycodone, Acetaminophen · Intervention Types: Drug, Drug
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Oxycodone
FDA approved
Ibuprofen
FDA approved
Acetaminophen
FDA approved
Ketorolac
FDA approved

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: at the end of hospitalization, up to 7 days after randomization

Who is running the clinical trial?

Washington University School of MedicineLead Sponsor
1,822 Previous Clinical Trials
2,283,722 Total Patients Enrolled

Eligibility Criteria

Age Any Age · Female Participants · 2 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
References