NSAIDs for Preeclampsia
(PANDA Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial is testing whether using common painkillers like ibuprofen after childbirth is safe for women who had severe high blood pressure during pregnancy. The study aims to see if these painkillers make their condition worse. Researchers hope to find out if these drugs can be safely used to reduce the need for stronger pain medications like opioids. Ibuprofen is a widely used nonsteroidal anti-inflammatory drug (NSAID) commonly prescribed for pain relief and inflammation.
Will I have to stop taking my current medications?
The trial information does not specify if you need to stop taking your current medications. However, if you have been using antihypertensive medications before 20 weeks of pregnancy, you cannot participate in the trial.
Is it safe to use NSAIDs for preeclampsia?
Are You a Good Fit for This Trial?
This trial is for women over 23 weeks pregnant at Barnes-Jewish Hospital diagnosed with severe preeclampsia, which includes very high blood pressure or issues like low platelets, liver problems, kidney trouble, lung fluid build-up, or persistent headaches. It's not for those who can't consent, have peptic ulcers or allergies to pain relievers used in the study, took certain blood pressure drugs early in pregnancy, have chronic kidney disease or a history of opioid abuse.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either an NSAID-free analgesic bundle or an NSAID analgesic bundle postpartum
Follow-up
Participants are monitored for safety and effectiveness after treatment, including opioid use, blood pressure, and antihypertensive requirements
What Are the Treatments Tested in This Trial?
Interventions
- Acetaminophen
- Ibuprofen
- Ketorolac
- Oxycodone
Oxycodone is already approved in United States, European Union, Canada for the following indications:
- Moderate to severe pain
- Chronic pain
- Severe pain
- Cancer pain
- Moderate to severe pain
Find a Clinic Near You
Who Is Running the Clinical Trial?
Washington University School of Medicine
Lead Sponsor