Ketorolac for Postpartum preeclampsia

Phase-Based Progress Estimates
Barnes Jewish Hospital, Saint Louis, MOPostpartum preeclampsia+1 MoreKetorolac - Drug
Any Age
What conditions do you have?

Study Summary

This trial tests if adding nonsteroidal anti-inflammatory drugs to preeclampsia treatment helps prevent postpartum hypertension.

Eligible Conditions
  • Postpartum preeclampsia
  • Pre-Eclampsia, Severe

Treatment Effectiveness

Study Objectives

1 Primary · 6 Secondary · Reporting Duration: at the end of hospitalization, up to 7 days after randomization

Week 6
Hospital readmission
Mean arterial blood pressure
Postpartum opioid use
Postpartum pain scores
Day 7
postpartum antihypertensive requirements
Day 4
End organ damage
up to 6 weeks
Continued anti-hypertensive requirement

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Trial Design

2 Treatment Groups

NSAID free analgesic bundle
1 of 2
NSAID Analgesic bundle
1 of 2

Active Control

Experimental Treatment

286 Total Participants · 2 Treatment Groups

Primary Treatment: Ketorolac · No Placebo Group · Phase 2

NSAID Analgesic bundleExperimental Group · 4 Interventions: Oxycodone, Ibuprofen 600 mg, Acetaminophen, Ketorolac · Intervention Types: Drug, Drug, Drug, Drug
NSAID free analgesic bundleActiveComparator Group · 2 Interventions: Oxycodone, Acetaminophen · Intervention Types: Drug, Drug
First Studied
Drug Approval Stage
How many patients have taken this drug
FDA approved
FDA approved
FDA approved
FDA approved

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: at the end of hospitalization, up to 7 days after randomization

Who is running the clinical trial?

Washington University School of MedicineLead Sponsor
1,822 Previous Clinical Trials
2,283,722 Total Patients Enrolled

Eligibility Criteria

Age Any Age · Female Participants · 2 Total Inclusion Criteria

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