11 Participants Needed

Blue Light Phototherapy

Recruiting at 1 trial location
DC
Overseen ByDermatology CTU
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial will use a special blue light to treat people with psoriasis vulgaris and Grover's Disease. The blue light helps reduce skin inflammation and makes skin cells grow more normally. This treatment is aimed at improving skin conditions for these patients. Blue light has been shown to be effective in treating psoriasis and other skin conditions by reducing inflammation and promoting normal skin cell growth.

Will I have to stop taking my current medications?

Yes, you will need to stop taking certain medications. If you are using topical or systemic treatments for your skin condition, you must stop them at least 2 weeks before starting the trial. Also, if you are taking specific drugs like topical steroids, calcineurin inhibitors, methotrexate, retinoids, or biologic agents for other issues, you cannot participate in the trial.

How does blue light phototherapy differ from other treatments for neonatal jaundice?

Blue light phototherapy is unique because it uses specific wavelengths of light to transform bilirubin into a form that can be more easily eliminated from the body, making it effective for treating neonatal jaundice. Unlike other treatments, it specifically targets the blue spectrum of light, which is most effective for this purpose.12345

What data supports the effectiveness of the treatment Blue Light Phototherapy?

Research shows that blue light phototherapy can have biological effects similar to ultraviolet A (UVA) radiation, which is used in dermatology to treat skin conditions. Additionally, studies comparing blue light to other light therapies suggest it can be effective in certain applications.678910

Who Is on the Research Team?

SX

Shuai Xu

Principal Investigator

Northwestern University

Are You a Good Fit for This Trial?

Inclusion Criteria

You have been diagnosed with psoriasis vulgaris or Grover's disease in the past.
Patient's aged 18-89 at time of enrollment

Exclusion Criteria

Unable to schedule phototherapy sessions
You have used any medication or treatment for your skin condition within the past 2 weeks before starting phototherapy.
We will not recruit the following populations: adults unable to consent, individuals who are not yet adults (infants, children, teenagers), pregnant women, prisoners and other vulnerable populations.
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Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive blue light phototherapy on affected areas for psoriasis or Grover's disease

5 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Long-term follow-up

Elucidate changes in circulatory T-cells based on flow cytometry and serum cytokines with blue light therapy

1 year

What Are the Treatments Tested in This Trial?

Interventions

  • Blue Light Phototherapy
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: Adult treatment armExperimental Treatment1 Intervention
Adults enrolled in the study will receive treatment (blue light phototherapy) on one area of their body affected by psoriasis or Grover's disease. The treatment area (restricted by size of the device) will be compared to untreated areas affected by disease on the same patient.

Find a Clinic Near You

Who Is Running the Clinical Trial?

Northwestern University

Lead Sponsor

Trials
1,674
Recruited
989,000+

T-Cellerate LLC

Industry Sponsor

Trials
1
Recruited
10+

T-Cellerate LLC

Collaborator

Trials
1
Recruited
10+

Published Research Related to This Trial

In a study involving 8 healthy volunteers, exposure to visible blue light over five consecutive days did not cause DNA damage or early signs of skin aging, indicating its safety for dermatological use.
The treatment resulted in transient melanogenesis, evidenced by a significant increase in Melan-A-positive cells, and caused vacuolization of keratinocytes, but did not lead to any inflammatory responses or apoptosis.
Clinical and histological effects of blue light on normal skin.Kleinpenning, MM., Smits, T., Frunt, MH., et al.[2010]

Citations

The systemic effect of 830-nm LED phototherapy on the wound healing of burn injuries: A controlled study in mouse and rat models. [2012]
Standardized bench method for evaluating the efficacy of phototherapy devices. [2019]
A prospective randomized controlled study of phototherapy using blue and blue-green light-emitting devices, and conventional halogen-quartz phototherapy. [2013]
Clinical and histological effects of blue light on normal skin. [2010]
Phototherapy with ultraviolet radiation: a study of hormone parameters and psychological effects. [2018]
Green light phototherapy in newborn infants with ABO hemolytic disease. [2019]
Neonatal blue light phototherapy and melanocytic nevi: a twin study. [2015]
Phototherapy for neonatal jaundice: optimal wavelengths of light. [2019]
Neonatal Blue Light Phototherapy and Melanocytic Nevus Count in Children: A Systematic Review and Meta-Analysis of Observational Studies. [2018]
Single-strand breaks in the DNA of human cells exposed to visible light from phototherapy lamps in the presence and absence of bilirubin. [2019]
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