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Behavioural Intervention

Transcranial Magnetic Stimulation (TMS) for Methamphetamine Abuse

N/A

Recruiting

Led By Sooraj John, M.D.

Research Sponsored by Carilion Clinic

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline/visit 2, day 5 of itbs/sham tms, 3 days after-, 1 week after-, 2 weeks-after, and one month after completion of itbs/sham tms

Awards & highlights

Study Summary

This trial is using a treatment called Transcranial Magnetic Stimulation (TMS) to see if it can help with treating Methamphetamine Use Disorder. People with this disorder will receive 5 TMS

Who is the study for?

This trial is for individuals struggling with Methamphetamine Use Disorder. Participants will be randomly assigned to receive either real TMS treatment or a sham (placebo) version over five consecutive sessions.Check my eligibility

What is being tested?

The study is testing the effectiveness of Transcranial Magnetic Stimulation (TMS), a non-invasive brain stimulation technique, in treating Methamphetamine Use Disorder compared to a sham procedure that mimics TMS without active treatment.See study design

What are the potential side effects?

TMS may cause discomfort at the site of application, headache, lightheadedness, or seizures in rare cases. The sham procedure should have fewer effects since it's designed to mimic TMS without delivering actual stimulation.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline/visit 2, daily during itbs/sham-tms, 3 days after-, 1 week after-, 2 weeks-after, and one month after completion of itbs/sham tms

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline/visit 2, daily during itbs/sham-tms, 3 days after-, 1 week after-, 2 weeks-after, and one month after completion of itbs/sham tms

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline/visit 2, daily during itbs/sham-tms, 3 days after-, 1 week after-, 2 weeks-after, and one month after completion of itbs/sham tms for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Stimulant Craving Questionnaire (STCQ)

Urine Drug Screen (UDS)

Secondary outcome measures

Clinical Global Impression - Improvement (CGI-I)

Clinical Global Impression - Severity (CGI-S)

Generalized Anxiety Disorder-7 (GAD-7)

+4 more

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Transcranial Magnetic Stimulation (TMS)Experimental Treatment1 Intervention

This arm receives the TMS treatments.

Group II: Sham-TMSPlacebo Group1 Intervention

This arm receives sham TMS treatments.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Transcranial Magnetic Stimulation

2017

Completed Phase 4

~730

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Carilion ClinicLead Sponsor

72 Previous Clinical Trials

12,722 Total Patients Enrolled

Virginia Polytechnic Institute and State UniversityOTHER

143 Previous Clinical Trials

27,773 Total Patients Enrolled

Sooraj John, M.D.Principal InvestigatorCarilion Clinic

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the enrollment for this study currently available to prospective participants?

"As per information from clinicaltrials.gov, this current research study is actively pursuing volunteers. The trial was initially shared on December 20th, 2023 and underwent the latest revision on April 15th, 2024."

Answered by AI

Is the clinical trial open to individuals younger than 75 years old?

"To be eligible for participation in this research study, individuals must fall within the age range of 18 to 55. Separate studies cater to patients below 18 years old and those aged over 65, with a total of 11 trials focusing on the latter group."

Answered by AI

What is the total number of participants involved in this clinical research study?

"Yes, current details on clinicaltrials.gov highlight that this investigation is actively recruiting participants. It was initially listed on December 20th, 2023, and most recently revised on April 15th, 2024. The study aims to enroll a total of 40 individuals at one designated site."

Answered by AI

Recent research and studies

American Journal of PsychiatryJournal

Stanford Accelerated Intelligent Neuromodulation Therapy for Treatment-resistant Depression

Cole, Eleanor J., Katy H. Stimpson, Brandon S. Bentzley, Merve Gulser, Kirsten Cherian, Claudia Tischler, Romina Nejad, et al.. 2020. “Stanford Accelerated Intelligent Neuromodulation Therapy for Treatment-resistant Depression”. American Journal of Psychiatry. American Psychiatric Association Publishing. doi:10.1176/appi.ajp.2019.19070720.

clinicaltrials.govStudy

Theta Burst TMS for Treatment of Methamphetamine Use Disorder

Sooraj John 2023. "Theta Burst TMS for Treatment of Methamphetamine Use Disorder". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06372288.

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