Novel DBS stimulation patterns for Parkinson Disease

1
Effectiveness
1
Safety
UNMC/Nebraska Medicine, Omaha, NE
Parkinson Disease+1 More
Novel DBS stimulation patterns - Device
Eligibility
18+
All Sexes
Eligible conditions
Parkinson Disease

Study Summary

This study is evaluating whether a new type of deep brain stimulation may help improve symptoms of Parkinson's disease.

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Eligible Conditions

  • Parkinson Disease
  • Parkinson's Disease (PD)

Treatment Effectiveness

Study Objectives

This trial is evaluating whether Novel DBS stimulation patterns will improve 1 primary outcome and 1 secondary outcome in patients with Parkinson Disease. Measurement will happen over the course of Years 1-2.

Years 1-2
Response to novel DBS stimulation patterns.
Safety and Tolerability of novel DBS stimulation patterns.

Trial Safety

Trial Design

2 Treatment Groups

Control
PD with DBS

This trial requires 10 total participants across 2 different treatment groups

This trial involves 2 different treatments. Novel DBS Stimulation Patterns is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

PD with DBS
Device
Patients with Parkinson's Disease who were implanted with Medtronic Percept PC for DBS and consent to participate in the study.
ControlNo treatment in the control group

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: years 1-2
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly years 1-2 for reporting.

Who is running the study

Principal Investigator
A. A.
Prof. Aviva Abosch, Professor and Chair Department of Neurosurgery
University of Nebraska

Closest Location

UNMC/Nebraska Medicine - Omaha, NE

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There is one eligibility criterion to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Patients with idiopathic Parkinson's Disease who were recommended for STN DBS using standard clinical inclusion

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many people get parkinson disease a year in the United States?

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About 1.2 million people are diagnosed with Parkinson's disease in the United States each year. Of these, roughly one-fourth, about 400,000, do so before the age of 50.

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What are the signs of parkinson disease?

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Parkinsonism is characterised by muscular stiffness, tremors and rigidity. The severity of these symptoms is related to disease stage, and are most pronounced in later stages. Symptoms typically start in only one side of the head (dominant side) however the severity and pattern of signs vary between patients.\n

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What are common treatments for parkinson disease?

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Oral dopaminergic agents are widely used in the treatment of PD. Cognitive therapies, such as yoga and meditation, are also often used. Surgery and deep brain stimulation may become increasingly utilized in future to alleviate some of the disabling symptoms of PD.

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Can parkinson disease be cured?

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The findings of the present study and published experience with neurosurgery for Parkinson's disease support the conclusion that neurosurgical interventions may be effective for improving motor symptoms.

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What is parkinson disease?

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PD is an insidious, long and disabling neurodegenerative disease characterized by abnormal movements, in particular, dyskinesia. Clinically there is significant variability, including differences in severity of symptoms between people, duration and rate of progression, and age at onset. The vast majority of PD-affected persons will eventually develop symptoms resulting from the motor and nonmotor symptoms. Although PD only occurs sporadically, the rapid rate of aging worldwide and the increasing incidence of PD could lead to an explosion in a future pandemic. summary: This article describes the diseases of the central nervous system: Alzheimer's disease, amyotrophic lateral sclerosis, and Parkinson's disease.

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What causes parkinson disease?

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In addition to toxins and genetics, an insult to the brain's autonomic nuclei, along with any other brain damage from injury, may cause PD. It is imperative that clinicians remember that PD can be a result of a number of diseases and conditions, and that there is no single cause.\n

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How serious can parkinson disease be?

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No matter what the nature of the disease, PD causes symptoms that people with PD will go to great lengths to hide and that the disease is associated with significant disability. PD affects quality of life, reduces employment opportunities, reduces overall productivity, and can be the cause of decreased social status. In order to prevent PD, there are a number of lifestyle actions people in their daily lives may consider making to reduce the risk of PD.

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Does novel dbs stimulation patterns improve quality of life for those with parkinson disease?

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A brief one-session stimulation can elicit a similar motor effect as a much longer two-session sessions, although the two-session dbs stimulation showed more sustained effects. This suggests that one-session dbs stimulation could be a feasible treatment to achieve immediate clinical benefits.

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Does parkinson disease run in families?

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A family history of PD was observed in 15%-20% of the healthy elderly population with an increasing rate of PD incidence with age. The risk was significantly higher for families with two or more PD-affected members who were siblings (OR 3.9, 95% CI 1.7-8.7) than for those without a family history of PD (OR 0.6, 95% CI 0.2-1.5) despite a wider age range and age dispersion among the spouses.

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What are the common side effects of novel dbs stimulation patterns?

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In our experience, stimulation parameters optimized for deep brain stimulation using the DBS system are very effective for improving the motor symptoms of PD. These stimulation patterns should be further investigated in both the research and treatment setting.

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What is the average age someone gets parkinson disease?

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It has been reported that the median age for Parkinson's disease onset is 60 (range 35-95). The average age of onset has been reported to be 53. [Power] gives a variety of clinical trials to find active Parkinson's disease treatment to find best treatment for your particular condition. [Power] has developed tools that can be accessed to search for clinical trials that may be the best for your specific case.

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What does novel dbs stimulation patterns usually treat?

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The stimulation pattern of an implanted stimulation system is highly predictable and highly personalized. This variability allows the neuro-physiologist to select the pattern of stimulation that fits the patients at the moment of patient setup. The choice of pattern can be made quickly and accurately during the first stimulation session.

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