Novel DBS stimulation patterns for Parkinson Disease

About 1.2 million people are diagnosed with Parkinson's disease in the United States each year. Of these, roughly one-fourth, about 400,000, do so before the age of 50.

Parkinsonism is characterised by muscular stiffness, tremors and rigidity. The severity of these symptoms is related to disease stage, and are most pronounced in later stages. Symptoms typically start in only one side of the head (dominant side) however the severity and pattern of signs vary between patients.\n

Oral dopaminergic agents are widely used in the treatment of PD. Cognitive therapies, such as yoga and meditation, are also often used. Surgery and deep brain stimulation may become increasingly utilized in future to alleviate some of the disabling symptoms of PD.

The findings of the present study and published experience with neurosurgery for Parkinson's disease support the conclusion that neurosurgical interventions may be effective for improving motor symptoms.

PD is an insidious, long and disabling neurodegenerative disease characterized by abnormal movements, in particular, dyskinesia. Clinically there is significant variability, including differences in severity of symptoms between people, duration and rate of progression, and age at onset. The vast majority of PD-affected persons will eventually develop symptoms resulting from the motor and nonmotor symptoms. Although PD only occurs sporadically, the rapid rate of aging worldwide and the increasing incidence of PD could lead to an explosion in a future pandemic. summary: This article describes the diseases of the central nervous system: Alzheimer's disease, amyotrophic lateral sclerosis, and Parkinson's disease.

In addition to toxins and genetics, an insult to the brain's autonomic nuclei, along with any other brain damage from injury, may cause PD. It is imperative that clinicians remember that PD can be a result of a number of diseases and conditions, and that there is no single cause.\n

No matter what the nature of the disease, PD causes symptoms that people with PD will go to great lengths to hide and that the disease is associated with significant disability. PD affects quality of life, reduces employment opportunities, reduces overall productivity, and can be the cause of decreased social status. In order to prevent PD, there are a number of lifestyle actions people in their daily lives may consider making to reduce the risk of PD.

A brief one-session stimulation can elicit a similar motor effect as a much longer two-session sessions, although the two-session dbs stimulation showed more sustained effects. This suggests that one-session dbs stimulation could be a feasible treatment to achieve immediate clinical benefits.

A family history of PD was observed in 15%-20% of the healthy elderly population with an increasing rate of PD incidence with age. The risk was significantly higher for families with two or more PD-affected members who were siblings (OR 3.9, 95% CI 1.7-8.7) than for those without a family history of PD (OR 0.6, 95% CI 0.2-1.5) despite a wider age range and age dispersion among the spouses.

In our experience, stimulation parameters optimized for deep brain stimulation using the DBS system are very effective for improving the motor symptoms of PD. These stimulation patterns should be further investigated in both the research and treatment setting.

It has been reported that the median age for Parkinson's disease onset is 60 (range 35-95). The average age of onset has been reported to be 53. [Power] gives a variety of clinical trials to find active Parkinson's disease treatment to find best treatment for your particular condition. [Power] has developed tools that can be accessed to search for clinical trials that may be the best for your specific case.