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Brain Activity and Neurochemical Monitoring for Epilepsy

N/A

Waitlist Available

Led By Robert Bina, MD

Research Sponsored by University of Arizona

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age 18 to 80 years, inclusive

Committee approved candidates for brain surgery

Timeline

Screening 3 weeks

Treatment Varies

Follow Up during hospitalization - 1-2 weeks

Awards & highlights

Study Summary

This trial will use computerized algorithms in combination with real-time recordings of brain activity and neurochemicals, as well as microstimulation, to measure cognitive and affective behavior in humans. Tasks given to subjects may be game-like, and questionnaires may also be used to characterize subjects' cognitive or affective states. This study will allow for a better understanding of human brain function.

Who is the study for?

This trial is for adults aged 18-80 with intractable epilepsy or similar conditions requiring brain surgery, fluent in English, and able to consent. Excluded are those with significant cognitive dysfunction, terminal illness, MRI contraindications (like pacemakers), current or planned pregnancy during the study.Check my eligibility

What is being tested?

The study tests how cognition and emotion behaviors are linked to brain activity using intracranial monitoring during behavioral tasks on a computer/iPad. It involves standard neuropsychological assessments pre-surgery and additional characterizations through questionnaires.See study design

What are the potential side effects?

Since this isn't a drug trial but an observational one involving standard clinical procedures for epilepsy treatment, specific side effects aren't listed; however, typical risks of neurosurgical procedures may apply.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am between 18 and 80 years old.

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I am approved for brain surgery by a committee.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ during hospitalization - 1-2 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~during hospitalization - 1-2 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and during hospitalization - 1-2 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Neurotransmitter Concentration Fluctuation and Pupillary Diameter in Sustained Attention Tasks

Neurotransmitter Concentration Fluctuation in Neuroeconomics Tasks

Neurotransmitter Concentration Fluctuation in Visual Memory

Trial Design

1Treatment groups

Experimental Treatment

Group I: Behavioral testing under intracranial monitoringExperimental Treatment1 Intervention

Patients will undergo behavioral tasks while being monitored by intercranial electrodes

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

Arizona State UniversityOTHER

283 Previous Clinical Trials

109,504 Total Patients Enrolled

1 Trials studying Epilepsy

17 Patients Enrolled for Epilepsy

University of ArizonaLead Sponsor

514 Previous Clinical Trials

148,261 Total Patients Enrolled

2 Trials studying Epilepsy

117 Patients Enrolled for Epilepsy

Virginia Polytechnic Institute and State UniversityOTHER

141 Previous Clinical Trials

27,756 Total Patients Enrolled

Media Library

Behavioral testing under intracranial monitoring Clinical Trial Eligibility Overview. Trial Name: NCT05273970 — N/A

Epilepsy Research Study Groups: Behavioral testing under intracranial monitoring

Epilepsy Clinical Trial 2023: Behavioral testing under intracranial monitoring Highlights & Side Effects. Trial Name: NCT05273970 — N/A

Behavioral testing under intracranial monitoring 2023 Treatment Timeline for Medical Study. Trial Name: NCT05273970 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there still vacancies to participate in this clinical trial?

"According to clinicaltrials.gov, the recruitment period for this trial has ended; it was initially made available on October 25th 2022 and has not been updated since then. However, there are currently 276 other medical studies actively looking for participants at present."

Answered by AI

Am I eligible for participation in this clinical trial?

"This clinical trial is open for recruitment to 10 participants aged 18-80 that possess cognitive abilities. The applicants must have the capacity to give informed consent and/or assent, proficiency in English, be a suitable candidate for electrode implantation due to drug-resistant epilepsy or other neurological afflictions necessitating subdural electrode placement, and have stabilized medications at least one month prior to surgery (all as approved by a committee)."

Answered by AI

Does this investigation provide an opportunity for elderly individuals to participate?

"Per the requirements of this trial, only individuals between 18 and 80 years old are eligible to apply. Additionally, there are 109 trials for minors and 184 studies that cater specifically to senior citizens."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Electrochemical and Electrophysiological Study

Robert Bina 2022. "Electrochemical and Electrophysiological Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05273970.