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Neurostimulation Device

active auricular tVNS for Healthy Subjects

Phase < 1
Recruiting
Led By Vitaly Napadow, PhD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 30 minutes
Awards & highlights

Study Summary

This trial will study how well vagus nerve stimulation works in people with Alzheimer's disease.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~30 minutes
This trial's timeline: 3 weeks for screening, Varies for treatment, and 30 minutes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Brain activity during functional magnetic resonance imaging (fMRI)
Stomach activity during gastric magnetic resonance imaging (MRI)
Secondary outcome measures
Electrocardiography (ECG)
Electrogastrography (EGG)
Respiration
+1 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: auricular tVNSExperimental Treatment2 Interventions
active and inactive auricular transcutaneous vagus nerve stimulation (tVNS)

Find a Location

Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor
2,918 Previous Clinical Trials
13,192,775 Total Patients Enrolled
National Institutes of Health (NIH)NIH
2,679 Previous Clinical Trials
6,910,622 Total Patients Enrolled
Vitaly Napadow, PhDPrincipal Investigator - Harvard University
Massachusetts General Hospital
4 Previous Clinical Trials
203 Total Patients Enrolled

Media Library

active auricular tVNS (Neurostimulation Device) Clinical Trial Eligibility Overview. Trial Name: NCT00200889 — Phase < 1
Healthy Subjects Research Study Groups: auricular tVNS
Healthy Subjects Clinical Trial 2023: active auricular tVNS Highlights & Side Effects. Trial Name: NCT00200889 — Phase < 1
active auricular tVNS (Neurostimulation Device) 2023 Treatment Timeline for Medical Study. Trial Name: NCT00200889 — Phase < 1
Healthy Subjects Patient Testimony for trial: Trial Name: NCT00200889 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research endeavor open to new participants?

"Affirmative, according to the clinicaltrials.gov listing this research is still accepting applicants. The trial was initially advertised on February 1st 2017 and most recently updated April 6th 2022, with 60 participants slated for one site."

Answered by AI

Who meets the criteria for participation in this medical experiment?

"To meet the inclusion criteria and be accepted, prospective patients must have healthy subjects (hs) and occupy an age range between 18-60 years old. This study is looking to recruit around 60 participants."

Answered by AI

Is this research initiative open to elderly participants?

"This clinical trial has set the lower limit of participant age at 18 and the upper limit at 60."

Answered by AI

What outcomes is the team attempting to uncover through this trial?

"This medical study, which will be conducted over a 1-hour period, aims to evaluate gastric activity through Magnetic Resonance Imaging (MRI). Secondary objectives include Respiration rate in Beats Per Minute (bpm), Skin Conductance Levels (SCL) evaluated in Volts per Second and Electrogastrography (EGG) for the assessment of slow wave myoelectrical power/peak frequency."

Answered by AI

How many individuals are enrolled in this experiment?

"Affirmative, the details hosted on clinicaltrials.gov point to this trial's active recruitment status. Originally posted in February 2017 and recently updated in April 2022, 60 patients are being sought from a single medical centre for participation."

Answered by AI

Who else is applying?

What state do they live in?
New York
New Hampshire
Massachusetts
How old are they?
18 - 65
What site did they apply to?
Massachusetts General Hospital
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
0

Why did patients apply to this trial?

Always willing to help science advance.
PatientReceived 1 prior treatment
~7 spots leftby Mar 2025