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NMDA Receptor Antagonist

Ketamine for Depression

Phase 2

Recruiting

Research Sponsored by TruDiagnostic

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up assessment will compare the difference in phq-9/pcl-5 scores from baseline to after treatment with change in biological age from baseline to post-treartment.

Awards & highlights

Study Summary

This trial will study whether ketamine can help treat depression or PTSD by measuring its impact on epigenetic aging.

Eligible Conditions

Depression
Post-Traumatic Stress Disorder

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ biological age will be compared from baseline to study completion, an average of five weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~biological age will be compared from baseline to study completion, an average of five weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and biological age will be compared from baseline to study completion, an average of five weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Epigenetic Age

Secondary outcome measures

Degree of Treatment Response

Severity of Illness and baseline epigenetic age

Severity of Illness and post-treatment epigenetic age

Trial Design

1Treatment groups

Experimental Treatment

Group I: Ketamine InfusionExperimental Treatment1 Intervention

subanesthetic ketamine infusion (0.5mg/kg) over 2-3 weeks

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Ketamine

2011

Completed Phase 4

~1090

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

TruDiagnosticLead Sponsor

11 Previous Clinical Trials

466 Total Patients Enrolled

Wild HealthUNKNOWN

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are recruitment efforts still ongoing for this clinical trial?

"Yes, this study requires more participants and was last updated on September 7th, 2022. The clinicaltrials website has the original posting date as April 1st, 2022."

Answered by AI

Is this research project only available to adults aged 25 and up?

"Eligibility for this specific clinical trial is restricted to patients aged 18-64. Out of the 1164 clinical trials available for people over 65 and the 222 trials geared towards those under 18, this is the only one that meets your age criteria."

Answered by AI

How many people total are included in this clinical trial?

"The clinical trial is still seeking participants, according to the information on clinicaltrials.gov. The study was originally posted on 4/1/2022 and was most recently edited on 9/7/2022. They are recruiting for 20 participants between 1 sites."

Answered by AI

Is Ketamine a short-term or long-term solution?

"There is some data supporting Ketamine's safety, but nothing concretely linking it to efficacy. As such, we've given it a score of 2."

Answered by AI

Might I be a right candidate for this clinical trial?

"The requirements for this study are that participants must have a diagnosis of depression and be within the specified age range. So far, 20 people have been enrolled in the trial."

Answered by AI

Who else is applying?

What state do they live in?

Oregon

Other

Tennessee

Kentucky

How old are they?

18 - 65

What site did they apply to?

Wild Health

What portion of applicants met pre-screening criteria?

Did not meet criteria

Met criteria

How many prior treatments have patients received?

Why did patients apply to this trial?

Tried multiple depression drugs including most recently resulting. Many failed medications, high cost of ketamine therapy, interest in supporting research.

PatientReceived no prior treatments

For approximately 30 yrs have been on/off (during 4 pregnancies and breastfeeding) SSRIs for OCD, generalized anxiety/panic disorder, depression.

PatientReceived 2+ prior treatments

I think I wrote a lot of this in the previous answer box, but I’ll put it here, too. The shirt version is: I’ve tried all traditional routes of medication (many of them at the same time, at HIGH dosages) and therapy, to no avail. Nothing has ever been able to help my brain get through this **** I’ve been dealing with for 20+ years. I am dealing with treatment resistant depression, CPTSD, and am also in eating disorder recovery. Last year, in August-December of 2022, I had a total of 8-9 infusions at a local clinic. Ketamine infusions are the ONLY thing in over 2 decades that have actually helped me believe recovery is possible for me, and that life can be worth it, helping me see a bigger picture of the life I really want to live, instead of being blinded by hopelessness and apathy and not being able to see any life remotely worth living. Unfortunately, our local clinic stopped being able to offer ketamine in any form (IV or IM) at the start of 2023, and I’ve been working with a telehealth psychiatrist to do at-home treatments a couple of times a week, in suppository form. I was hoping that would have helped me much more than it has after 6 months, but I’ve yet to have a single dose experience with the at-home method (I’m currently on 350mg at home) that has given me any of the distance perspective, insight/realization, or help me care enough to believe recovery and life are worth it. I REALLY need to be able to access infusions, because for over 20 years, the months in which I got those infusions gave me the ONLY moments where hopelessness was gone and I could feel hope again. I haven’t felt hope for nearly 6 months now. I’m desperate for relief, and I know from experience ketamine infusions have been able to do that. I cannot afford to keep being stalled in my recovery anymore. I really need this help. My cell number is 606-923-3531, though I’m honestly much more comfortable communicating via email when possible, and my email address is: grammatically.so@gmail.com. I live in Ashland, but if I’m able to be accepted into this, I can make the trips to Lexington (with someone else driving me, of course).

PatientReceived 2+ prior treatments