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High-Intensity Treadmill Training for Multiple Sclerosis
Study Summary
This trial combines intense exercise with walking on a shaky treadmill to improve walking speed, balance and walking in the community for people with MS. Measurements taken before, during, and after.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I have no neurological diseases, seizures, nerve injuries in my legs, or brain injuries.I am between 18 and 65 years old and weigh less than 135kg.I haven't had a heart attack in the last month, my blood pressure is under control, I don't get dizzy standing up, and my diabetes is managed.I can walk and move my ankles, knees, and hips within a normal range.I can hear whispers and see clearly with glasses if needed.I can follow simple instructions.I have MS diagnosed by McDonald Criteria with a stable condition and no recent exacerbations.I am not pregnant nor planning to become pregnant, and I can use safety restraints.My MS treatments have been stable for 1 month, with no recent steroids or botulinum toxin injections above the knee.I can walk 10 meters on my own or with minimal help and don't have severe spasticity or exercise intolerance.I am medically stable and do not have severe illnesses that would limit my ability to exercise.I am not currently in physical therapy or supervised exercise programs.
- Group 1: Moderate-Intensity No Perturbations
- Group 2: High-Intensity With Pertubations
- Group 3: Moderate-Intensity With Perturbations
- Group 4: High-Intensity No Perturbations
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Could elderly individuals aged 85 and over partake in this experiment?
"According to the stated eligibility guidelines, patients must be between 18 and 65 years old in order to qualify for this clinical trial."
Is recruitment into this investigation still ongoing?
"According to clinicaltrials.gov, this medical experiment is open for enrollment and was initially published on January 1st 2023 with the most recent update occurring on February 9th 2023."
How many participants are currently involved in this clinical experiment?
"Affirmative. The information available on clinicaltrials.gov demonstrats that this medical trial is currently accepting participants and was initially posted on 1/1/2023 with the most recent update taking place 2/9/2023. A total of 150 individuals will be recruited from two distinct sites for this experiment."
Could I qualify to join this medical trial?
"This clinical trial seeks 150 individuals aged 18 to 65 with an established diagnosis of multiple sclerosis according to the McDonald Criteria. Patient eligibility is contingent on several factors such as having a stable disease course, no exacerbations in the past four weeks, being able to follow three commands during a Mini Mental State Exam and medically stable without concurrent severe medical illnesses. Furthermore, participants must have adequate hearing (whisper test) and vision (minimum 20/80 corrected vision on a Snellen chart), not exceed 135 kg body mass index for treadmill equipment use and be free from myocardial infarction in the past month or uncontrolled hypertension (blood pressure"
What is the focal purpose of this research initiative?
"The purpose of this trial, which will be tracked over the course of 5-6 weeks before training starts, 1-2 weeks after completion of all sessions and 6 months afterwards is to assess changes in Timed 25-foot walk test. Auxiliary outcomes include fluctuations in Berg Balance Scale, number of falls incidents and kinematic responses to unpredicted perturbations determined by motion capture technology measuring center mass displacement and base support as well as medial/lateral margin stability and anterior/posterior dynamic gait steadiness assessed with step sizes and trunk angles."
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