Pulsed Radiotherapy for Brain Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial studies the side effects of a new method of giving radiation in small, timed doses, in patients with certain types of brain tumors who have had earlier treatments. This approach may be more effective and less harmful.
Will I have to stop taking my current medications?
The trial requires you to stop taking bevacizumab (a medication used to treat certain types of cancer) at least 4 weeks before starting the study. Other medications like chemotherapy or immunotherapy can be continued, but it's best to discuss with your doctor.
Is pulsed radiotherapy generally safe for humans?
There is limited safety data specifically on pulsed radiotherapy for brain cancer in humans, but related treatments like temozolomide with radiation therapy have shown some side effects such as fatigue, nausea, and blood-related issues. Severe side effects are rare, but they can include significant blood problems.12345
How is the treatment TMPRT different from other treatments for brain cancer?
TMPRT (Temporally-modulated Pulsed Radiation Therapy) is unique because it delivers radiation in pulses, which has shown to effectively control tumors while better sparing normal tissue compared to standard radiotherapy. This approach is being investigated for its potential benefits in treating newly diagnosed glioblastoma, a type of aggressive brain cancer.678910
What data supports the effectiveness of the treatment TMPRT for brain cancer?
Research shows that pulsed radiation therapy (PRT) can effectively control tumors and protect normal tissue better than standard radiotherapy in brain cancer models. Additionally, combining pulsed radiation with drugs like temozolomide has shown promising results in treating resistant brain tumors in animal studies.236711
Who Is on the Research Team?
Jiayi Huang, M.D.
Principal Investigator
Washington University School of Medicine
Are You a Good Fit for This Trial?
This trial is for adults with IDH-mutant gliomas (brain tumors) who've had prior radiation. They should have a life expectancy of over a year, be able to consent, and women must use birth control. It's not for pregnant individuals or those with certain medical conditions that conflict with the treatment.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Radiation
Participants receive temporally-modulated pulsed radiation therapy (TMPRT) daily as 10 pulses of 0.2 Gy each with a 3-minute interval between pulses to a total dose of 54 Gy at 2 Gy per day. Treatment continues for a total of 27 fractions.
Follow-up
Participants are monitored for safety and effectiveness after treatment, including assessments of quality of life and symptom burden.
What Are the Treatments Tested in This Trial?
Interventions
- TMPRT
Find a Clinic Near You
Who Is Running the Clinical Trial?
Washington University School of Medicine
Lead Sponsor