Pembrolizumab + Interleukin-12 for Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial is testing a combination of two treatments for patients with solid tumors. One treatment helps the immune system attack cancer, and the other cuts off the tumor's blood supply and boosts the immune response. The goal is to find the best dose and see if this combination works effectively. Combining targeted and immunotherapy is a rapidly growing practice in solid tumors and provides a glimpse of hope in situations that previously lacked any treatment option.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications. However, you cannot participate if you are on systemic steroid therapy or immunosuppressive therapy within 7 days before the trial starts. It's best to discuss your specific medications with the trial team.
Is the combination of Pembrolizumab and Interleukin-12 safe for humans?
Pembrolizumab, also known as Keytruda, has been studied for safety in humans and is generally considered safe, but it can cause some immune-related side effects like type 1 diabetes in rare cases and pneumonitis (lung inflammation) in 1%-5% of patients. In nonhuman primate studies, no significant toxic effects were observed. However, specific safety data for the combination with Interleukin-12 is not provided in the available research.12345
What makes the drug Pembrolizumab + Interleukin-12 unique for cancer treatment?
This treatment combines Pembrolizumab, a drug that helps the immune system attack cancer by blocking a pathway that tumors use to hide, with Interleukin-12, which boosts the immune response. This combination aims to enhance the body's ability to fight cancer more effectively than using either component alone.12567
What data supports the effectiveness of the drug Pembrolizumab + Interleukin-12 for cancer?
Who Is on the Research Team?
Diwakar Davar, MD
Principal Investigator
University of Pittsburgh Cancer Institute LAO
Are You a Good Fit for This Trial?
This trial is for adults with solid tumors that have worsened after anti-PD-(L)1 therapy. They must be in good physical condition, not pregnant or breastfeeding, and willing to use birth control. People can't join if they've had recent cancer treatments, other active cancers, immune system problems, untreated brain metastases, severe allergies to study drugs, or are on steroids.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Patients receive recombinant interleukin-12 subcutaneously and pembrolizumab intravenously over multiple cycles
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Edodekin alfa
- Pembrolizumab
Find a Clinic Near You
Who Is Running the Clinical Trial?
National Cancer Institute (NCI)
Lead Sponsor