Treatment for Adenocarcinoma

1
Effectiveness
1
Safety
University Health Network, Toronto, Canada
Adenocarcinoma+1 More
Eligibility
18+
All Sexes
Eligible conditions
Adenocarcinoma

Study Summary

This study is evaluating whether high resolution ultrasound can help doctors diagnose pancreatic cancer.

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Eligible Conditions

  • Adenocarcinoma
  • Pancreatic Adenocarcinoma (Ductal Adenocarcinoma)

Treatment Effectiveness

Study Objectives

This trial is evaluating whether Treatment will improve 1 primary outcome in patients with Adenocarcinoma. Measurement will happen over the course of within 2 weeks of surgery.

Week 2
High-resolution U/S will be used to measure vascular invasion and regional lymph node metastases in PDAC

Trial Safety

Trial Design

1 Treatment Groups

Control

This trial requires 30 total participants across 1 different treatment groups

This trial involves a single treatment. Treatment is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

ControlNo treatment in the control group

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: within 2 weeks of surgery
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly within 2 weeks of surgery for reporting.

Closest Location

University Health Network - Toronto, Canada

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 4 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
PDAC diagnosed by typical imaging findings or pathology
Scheduled for surgical resection
Contrast enhanced CT scan performed locally at UHN
Males and females > 18 y

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are common treatments for adenocarcinoma?

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Chemotherapy and radiation therapy are commonly used for adenocarcinoma, and the use of both is associated with significantly improved survival over surgery alone or surgery combined with non-modifiable treatments.

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Can adenocarcinoma be cured?

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Adenocarcinoma can not be cured, but with good and proper treatment, symptoms can be practically eliminated and the malignant degeneration process can be practically slowed down.

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What is adenocarcinoma?

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In the United Kingdom, adenocarcinoma of the large bowel is the second-most common presentation of colorectal cancers after non-mucinous adenocarcinoma of the colon. However, since the United Kingdom has a national health system, there is a wide choice of healthcare alternatives and treatment options for gastrointestinal diseases. Further research is needed to determine the true epidemiology of adenocarcinomas of the colon when compared to other regions.

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What are the signs of adenocarcinoma?

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As tumors arise from epithelial tissues, many tumors in the liver and pancreas are adenocarcinomas, in which carcinoma cells infiltrate the liver and pancreas, infiltrating the surrounding healthy tissue as they migrate through the blood vessels into the affected organs. Thus, adenocarcinoma of the breast and rectum typically causes systemic symptoms, such as anemia, weight loss, and anorexia. Other liver and pancreatic cancers may metastasize to the brain, lymph nodes, bones, gall bladder or the skin, and in this way can be difficult to identify clinically as adenocarcinomas.

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How many people get adenocarcinoma a year in the United States?

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1 in 16 men will be diagnosed with adenocarcinoma of the colorectum/rectum in a given year in the United States. This gives a 1 in 26 average lifetime risk of CRC development, higher than in the general population. These numbers are important for the surveillance populations since these are the patients most likely to benefit from colonoscopic surveillance.

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What causes adenocarcinoma?

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The cause of adenocarcinoma, and probably squamous cell carcinoma and other lung cancers, may be influenced by factors in the tobacco, chemical environment, and lifestyle of the person exposed.

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Is treatment safe for people?

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Many cancers behave similarly in the primary and metastatic stages of disease. Most metastatic cancers do not benefit from aggressive treatment because it is unlikely that metastasizing cells had a major role in primary cancer growth or development. Treatment regimens based on the primary cancer behavior need to be reevaluated.

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What is the primary cause of adenocarcinoma?

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Adenocarcinomas occur predominantly in smokers but may develop without smoking. Adenocarcinoma occurring in nonsmokers frequently has no history of smoking. Nonsmokers with adenocarcinoma of the lung, the esophagus, the pancreas and colorectum (all subtypes) are frequently elderly males.

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What is the average age someone gets adenocarcinoma?

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We have found average age of diagnosis is around 40. We have found adenocarcinoma to be 4 times more common (0.7%) in males than females. In the past decade, this type of cancer has become much more common than several years ago. Most people with adenocarcinoma experience early stage disease that is still treatable. [GICC|Glioma in cell cycle regulated protein (G1) inhibitor, gene 3; CCNE1|cyclin E1]] gene is amplified, and overexpressed in adenocarcinoma. In adenocarcinoma, the G1/S checkpoint regulates the G1 phase of the cell cycle.

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What are the latest developments in treatment for therapeutic use?

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Current research is aimed at developing better and more effective drugs and new gene therapies that could be promising in the treatment of this disease.

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Is treatment typically used in combination with any other treatments?

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Patients received the following types of treatment more than one of the other treatments, regardless of location of disease. Lung cancer patients were more likely to receive a complete resection of the tumor than other cancers (e.g. pancreas, colon, and prostate).

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Does treatment improve quality of life for those with adenocarcinoma?

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In a recent study, findings provides evidence that there are no differences in QOL, as measured by the European Organisation for Research and Treatment of Cancer Quality of Life questionnaire, between respondents who received chemotherapy and those who received palliative surgery by 3 months post-diagnosis.

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