PRP for Eyebrow Hypotrichosis and Alopecia Areata

Overseen By Derm CTU

Age: 18+

Sex: Any

Trial Phase: Phase 2

Sponsor: Northwestern University

Must not be taking: Anticoagulants, Anti-platelets, Minoxidil, others

Disqualifiers: Alopecia, Cancer, Thyroid diseases, others

Prior Safety Data This treatment has passed at least one previous human trial

Compensation: Varies

Number of Visits: 3

Duration: 3 months

11 Participants Needed

Trial Summary

What is the purpose of this trial?

The purpose of this study is to evaluate the effect of autologous platelet-rich plasma (PRP) in the treatment of mild to moderate eyebrow hypotrichosis. This is a randomized clinical trial to evaluate the effect of autologous platelet rich plasma in subjects with mild to moderate eyebrow hypotrichosis. Approximately 40 subjects will be randomized to receive platelet-rich plasma (PRP) or saline injections. The study is designed as an 9-month study. This study was a pilot study designed to determine feasibility of this procedure. Subjects currently living in the Chicago metropolitan area and meet inclusion/exclusion criteria will be considered for enrollment.

Research Team

Murad Alam

Principal Investigator

Northwestern University

Eligibility Criteria

This trial is for adults aged 18-85 in the Chicago area with mild to moderate eyebrow thinning who are healthy and can give informed consent. It's not for those with uncontrolled diseases affecting hair growth, recent use of certain hair growth drugs, significant blood disorders, genetic conditions impacting fibroblasts or collagen, pregnant/breastfeeding individuals, or those unable to follow the study protocol.

Inclusion Criteria

Subjects who are willing and have the ability to understand and provide informed consent for participation in the study and are able to communicate with the investigator

Subjects are in good health as judged by the investigator

You have thin eyebrows, but not too severe.

Exclusion Criteria

You have a medical condition that is not well controlled and could prevent your hair from growing properly.

Patients who have started used agents that may affect eyebrow hair growth (e.g. minoxidil or bimatoprost) within 6 months of screening. Patients who have been using agents that may affect eyebrow hair growth for at least 12 months may be included if the patient agrees to continue their current dosing regimen for the duration of the study

History of a clinically significant hematologic disorder as determined by the investigator

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive intradermal injections of either autologous PRP or sterile saline to eyebrows, with three treatments performed 1 month apart

3 months

3 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

6 months

Treatment Details

Interventions

• Platelet-rich Plasma
• Saline

Trial Overview The trial tests if injections of platelet-rich plasma (PRP) help people with sparse eyebrows compared to saline (saltwater) injections. About 40 participants will be randomly chosen to receive either PRP or saline over a period of nine months in this pilot study aimed at assessing procedure feasibility.

Participant Groups

Group I: Platelet-Rich Plasma Experimental Treatment 1 Intervention

Participants will receive intradermal injections of 2-3mL autologous PRP to eyebrows.Three treatments will be performed 1 month apart.

Group II: Placebo (sterile saline) Placebo Group 1 Intervention

Participants will receive intradermal injections of 2-3mL sterile saline to eyebrows.Three treatments will be performed 1 month apart.

Who Is Running the Clinical Trial?

Northwestern University

Lead Sponsor

Trials

1,674

Recruited

989,000+