Platelet-rich plasma (PRP) for Wrist Injuries
Phase-Based Progress Estimates
Effectiveness
Safety
Wrist Injuries+2 More
Platelet-rich plasma (PRP) - ProcedureEligibility
Any Age
All Sexes
What conditions do you have?
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Eligibility
Any Age
All Sexes
What conditions do you have?
Select
Study Summary
This trial will study whether Platelet-rich Plasma (PRP), a blood concentrate with high levels of growth factors, can help heal Triangular FibroCartilage Complex (TFCC) injuries.
Eligible Conditions
- Wrist Injuries
- PRP
Treatment Effectiveness
Study Objectives
1 Primary · 4 Secondary · Reporting Duration: Pre-injection, 2 weeks, 3 months, 6 months, 12 months
12 months post injection
Disability of the Army Shoulder Hand (DASH)
Month 3
Michigan Hand Outcome Questionnaire (MHOQ
Pain Anxiety Symptom Scale (PASS)
Month 12
Mayo Wrist Score (Mayo)
Single Assessment Numerical Evaluation (SANE)
Trial Safety
Trial Design
2 Treatment Groups
Experimental - PRP injection
1 of 2
control - Saline injection
1 of 2
Experimental Treatment
Non-Treatment Group
42 Total Participants · 2 Treatment Groups
Primary Treatment: Platelet-rich plasma (PRP) · Has Placebo Group · N/A
Experimental - PRP injection
Procedure
Experimental Group · 1 Intervention: Platelet-rich plasma (PRP) · Intervention Types: Procedurecontrol - Saline injection
Procedure
PlaceboComparator Group · 1 Intervention: Platelet-rich plasma (PRP) · Intervention Types: ProcedureTreatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Platelet-rich plasma (PRP)
2009
Completed Early Phase 1
~10
Trial Logistics
Trial Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: pre-injection, 2 weeks, 3 months, 6 months, 12 months
Who is running the clinical trial?
William Beaumont Army Medical CenterLead Sponsor
16 Previous Clinical Trials
2,304 Total Patients Enrolled
John C DunnPrincipal InvestigatorWBAMC Staff Hand Surgeon
Eligibility Criteria
Age Any Age · All Participants · 2 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:About The Reviewer
Michael Gill - B. Sc.
First Published: October 4th, 2021
Last Reviewed: November 9th, 2022
Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.
References
- Hsu, W. K., A. Mishra, S. R. Rodeo, F. Fu, M. A. Terry, P. Randelli, S. T. Canale, and F. B. Kelly. 2013. “Platelet-rich Plasma in Orthopaedic Applications: Evidence-based Recommendations for Treatment”. Journal of the American Academy of Orthopaedic Surgeons. Ovid Technologies (Wolters Kluwer Health). doi:10.5435/jaaos-21-12-739.
- Hsu, Wellington K., Allan Mishra, Scott R. Rodeo, Freddie Fu, Michael A. Terry, Pietro Randelli, Terry S. Canale, and Frank B. Kelly. 2013. “Platelet-rich Plasma in Orthopaedic Applications: Evidence-based Recommendations for Treatment”. Journal of the American Academy of Orthopaedic Surgeons. Ovid Technologies (Wolters Kluwer Health). doi:10.5435/jaaos-22-08-469.
- Peerbooms, Joost C., Jordi Sluimer, Daniël J. Bruijn, and Taco Gosens. 2010. “Positive Effect of an Autologous Platelet Concentrate in Lateral Epicondylitis in a Double-blind Randomized Controlled Trial”. The American Journal of Sports Medicine. SAGE Publications. doi:10.1177/0363546509355445.
- Gosens, Taco, Joost C. Peerbooms, Wilbert van Laar, and Brenda L. den Oudsten. 2011. “Ongoing Positive Effect of Platelet-rich Plasma Versus Corticosteroid Injection in Lateral Epicondylitis”. The American Journal of Sports Medicine. SAGE Publications. doi:10.1177/0363546510397173.
- Palmer, Andrew K., and Frederick W. Werner. 1981. “The Triangular Fibrocartilage Complex of the Wrist—anatomy and Function”. The Journal of Hand Surgery. Elsevier BV. doi:10.1016/s0363-5023(81)80170-0.
- Heyworth, Benton E., Jonathan H. Lee, Paul D. Kim, Carter B. Lipton, Robert J. Strauch, and Melvin P. Rosenwasser. 2008. “Hylan Versus Corticosteroid Versus Placebo for Treatment of Basal Joint Arthritis: A Prospective, Randomized, Double-blinded Clinical Trial”. The Journal of Hand Surgery. Elsevier BV. doi:10.1016/j.jhsa.2007.10.009.
- Dai, Wen-Li, Ai-Guo Zhou, Hua Zhang, and Jian Zhang. 2017. “Efficacy of Platelet-rich Plasma in the Treatment of Knee Osteoarthritis: A Meta-analysis of Randomized Controlled Trials”. Arthroscopy: The Journal of Arthroscopic & Related Surgery. Elsevier BV. doi:10.1016/j.arthro.2016.09.024.
- Heyworth, Benton E., Jonathan H. Lee, Paul D. Kim, Carter B. Lipton, Robert J. Strauch, and Melvin P. Rosenwasser. 2008. “Hylan Versus Corticosteroid Versus Placebo for Treatment of Basal Joint Arthritis: A Prospective, Randomized, Double-blinded Clinical Trial”. The Journal of Hand Surgery. Elsevier BV. doi:10.1016/j.jhsa.2007.10.009.
- Gosens, Taco, Joost C. Peerbooms, Wilbert van Laar, and Brenda L. den Oudsten. 2011. “Ongoing Positive Effect of Platelet-rich Plasma Versus Corticosteroid Injection in Lateral Epicondylitis”. The American Journal of Sports Medicine. SAGE Publications. doi:10.1177/0363546510397173.
- Peerbooms, Joost C., Jordi Sluimer, Daniël J. Bruijn, and Taco Gosens. 2010. “Positive Effect of an Autologous Platelet Concentrate in Lateral Epicondylitis in a Double-blind Randomized Controlled Trial”. The American Journal of Sports Medicine. SAGE Publications. doi:10.1177/0363546509355445.
- John C. Dunn 2020. "A Prospective Randomized Double Blinded Controlled Trial of Non-Operative Management of TFCC Injuries". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03830775.
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