Reviewed by Michael Gill, B. Sc.
25 Degenerative Disc Disease Clinical Trials Near Me
Top Hospitals for Degenerative Disc Disease Clinical Trials
Image of Orthopaedic Institute of Western Kentucky in Kentucky.
Orthopaedic Institute of Western Kentucky
3Active Trials
14All Time Trials for Degenerative Disc Disease
2017First Degenerative Disc Disease Trial
Image of Indiana Spine Group in Indiana.
Indiana Spine Group
3Active Trials
11All Time Trials for Degenerative Disc Disease
2006First Degenerative Disc Disease Trial
Top Cities for Degenerative Disc Disease Clinical Trials
Top Treatments for Degenerative Disc Disease Clinical Trials
Treatment Name
Active Degenerative Disc Disease Clinical Trials
All Time Trials for Degenerative Disc Disease
First Recorded Degenerative Disc Disease Trial
MagnetOs Putty
Prefix 150
Platelet-rich plasma (PRP), Platelet lysate (PL), and Platelet Poor Plasma (PPP)

What Are Degenerative Disc Disease Clinical Trials?

Degenerative Disc Disease is the condition in which one or more of your spinal discs cause pain due to deterioration. This deterioration usually occurs from normal wear and tear and is usually an age-associated condition that manifests more strongly after the age of 40. Different factors, like lifestyle, certain injuries, and even improper posture, can contribute to its acceleration. However, not all spinal pains originate from Degenerative Disc Disease.

Degenerative Disc Disease clinical trials are research studies with human subjects conducted to better understand the condition and explore possible treatments, their efficiency, and possible adverse side effects.

Why Is Degenerative Disc Disease Being Studied Through Clinical Trials?

Degenerative Disc Disease is one of the most common age-related diseases, and it’s estimated that two out of five (40%) adults over the age of 40 suffer from it. That’s equivalent to about a billion people on the planet right now, or one in every eight people.

A widespread disease that leads to low-level chronic pain that people have to endure throughout their lives warrants considerable resources diverted towards its remediation and treatment, and that's what Degenerative Disc Disease clinical trials aim to do. Clinical trials are also necessary to ensure that the most commonly used treatments do not have adverse side effects or drug interactions with other medications for age-related diseases a person might be taking.

What Are The Types of Treatments Available For Degenerative Disc Disease?

There are multiple treatments for Degenerative Disc Disease, from lifestyle changes to surgeries.

Lifestyle changes, including diet, exercise, and weight loss, cannot revert the deterioration that has already happened in the spinal discs, but they can alleviate the pain to a considerable degree and prevent/accelerate further deterioration. Physical therapy can help you build the right back muscles.

A variety of medications can be used to treat the pain caused by Degenerative Disc Disease and the choice is made based on the severity of the pain and other related conditions. Nonsteroidal Anti-inflammatory Drugs like ibuprofen are useful for low back pain. Often, the pain from the disease comes from a pinched nerve, which can be severe. Corticosteroids can be used to reduce the swelling near the affected disk, reducing pain. Muscle relaxants are used for the same effect, and prescription pain drugs may be recommended for severe pain.

The final stage of medical intervention for Degenerative Disc Disease is surgery. The surgeon may:

  • Remove part of or the entire affected disc and replace it with an artificial disc.
  • Fuse the degenerated disc(s) with another, so there is no grinding.

What Are Some Recent Breakthrough Clinical Trials For Degenerative Disc Disease?

2020: Novel Hydrogel Injection To Treat Degenerative Disc Disease - 23 patients suffering from severe Degenerative Disc Disease with at least three deteriorated spinal discs. The gel was injected between the discs, and the results were tracked over a 24-week period. There was a significant improvement in pain reduction, and the MRI also revealed improvement. One version of this novel gel has already received FDA’s breakthrough device designation.

2021: P-15L Bone Graft For Degenerative Disc Disease - Another potentially breakthrough clinical trial is currently underway which aims to determine if P-15L Bone Graft technology, which already has a breakthrough device status from the FDA, is comparable in its effectiveness to lumbar fusion.

Who Are Some Of The Key Opinion Leaders / Researchers / Institutions Conducting Degenerative Disc Disease Clinical Trial Research?

Medtronic Spine and NuVasive - The two companies are responsible for the highest number of clinical trials on Degenerative Disc Disease and are responsible for some of the most cutting-edge technologies and procedures in this domain.

About The Author

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 5th, 2021

Last Reviewed: November 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.

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