This trial is testing whether a product made from amniotic fluid can help relieve pain and improve function for people with all types of musculoskeletal conditions.
- Ligament Injury
- Degenerative Disc Disease
- Sports Injuries
- Pelvic Pain
1 Primary · 2 Secondary · Reporting Duration: Baseline and then Assess Changes Post Intervention at 4 weeks, 3 mths, 6 mths, 9 mths and one year
Awards & Highlights
1 Treatment Group
1 of 1
200 Total Participants · 1 Treatment Group
Primary Treatment: Umbilical Allograft · No Placebo Group · N/A
Who is running the clinical trial?
Age 18+ · All Participants · 0 Total Inclusion CriteriaMark “Yes” if the following statements are true for you:
Who else is applying?
What state do they live in?
What portion of applicants met pre-screening criteria?
What site did they apply to?
|Stem Cell Therapy of Las Vegas||66.7%|
|Advanced Stem Cell Institute||33.3%|
Why did patients apply to this trial?
- "I have pain in my knees. My left knee has a radial tear of the meniscus. I have only been offered menisectomy as a treatment choice and this will only lead to increased osteoarthritis and eventually total knee replacement. I am interested to be part of this study to see if stem cells will help."
- "I am frustrated that my life has diminished because of OA, back issues with stenosis and discs and there are no good treatment options available. I've been interested in stem cell therapy for a while but have not made a decision if I think my own stem cells should be the source. Umbilical derived cells seem like a better option. I think this approach has great promise and it is time that we have more research into umbilical derived options in the US."
How many prior treatments have patients received?
How responsive is this trial?
Typically responds via
Most responsive sites:
- Advanced Stem Cell Institute: < 24 hours
Average response time
- < 1 Day
- Soncini, Maddalena, Elsa Vertua, Lucia Gibelli, Fausto Zorzi, Marco Denegri, Alberto Albertini, Georg S. Wengler, and Ornella Parolini. 2007. “Isolation and Characterization of Mesenchymal Cells from Human Fetal Membranes”. Journal of Tissue Engineering and Regenerative Medicine. Wiley. doi:10.1002/term.40.
- De Coppi, Paolo, Georg Bartsch Jr, M Minhaj Siddiqui, Tao Xu, Cesar C Santos, Laura Perin, Gustavo Mostoslavsky, et al.. 2007. “Isolation of Amniotic Stem Cell Lines with Potential for Therapy”. Nature Biotechnology. Springer Science and Business Media LLC. doi:10.1038/nbt1274.
- Aagaard-Tillery, Kjersti M., Robert Silver, and Jess Dalton. 2006. “Immunology of Normal Pregnancy”. Seminars in Fetal and Neonatal Medicine. Elsevier BV. doi:10.1016/j.siny.2006.04.003.
- Delo, Dawn M., Paolo De Coppi, Georg Bartsch Jr., and Anthony Atala. 2006. “Amniotic Fluid and Placental Stem Cells”. Adult Stem Cells. Elsevier. doi:10.1016/s0076-6879(06)19017-5.
- Shay, Elizabeth, Ahmad Kheirkhah, Lingyi Liang, Hossam Sheha, Darren G. Gregory, and Scheffer C.G. Tseng. 2009. “Amniotic Membrane Transplantation as a New Therapy for the Acute Ocular Manifestations of Stevens-johnson Syndrome and Toxic Epidermal Necrolysis”. Survey of Ophthalmology. Elsevier BV. doi:10.1016/j.survophthal.2009.03.004.
- Aagaard-Tillery KM, Silver R, Dalton J. Immunology of normal pregnancy. Semin Fetal Neonatal Med. 2006 Oct;11(5):279-95. doi: 10.1016/j.siny.2006.04.003. Epub 2006 Jun 19.
- Shay E, Kheirkhah A, Liang L, Sheha H, Gregory DG, Tseng SC. Amniotic membrane transplantation as a new therapy for the acute ocular manifestations of Stevens-Johnson syndrome and toxic epidermal necrolysis. Surv Ophthalmol. 2009 Nov-Dec;54(6):686-96. doi: 10.1016/j.survophthal.2009.03.004. Epub 2009 Aug 21.
- Delo DM, De Coppi P, Bartsch G Jr, Atala A. Amniotic fluid and placental stem cells. Methods Enzymol. 2006;419:426-38. doi: 10.1016/S0076-6879(06)19017-5.
- De Coppi P, Bartsch G Jr, Siddiqui MM, Xu T, Santos CC, Perin L, Mostoslavsky G, Serre AC, Snyder EY, Yoo JJ, Furth ME, Soker S, Atala A. Isolation of amniotic stem cell lines with potential for therapy. Nat Biotechnol. 2007 Jan;25(1):100-6. doi: 10.1038/nbt1274. Epub 2007 Jan 7.
- Soncini M, Vertua E, Gibelli L, Zorzi F, Denegri M, Albertini A, Wengler GS, Parolini O. Isolation and characterization of mesenchymal cells from human fetal membranes. J Tissue Eng Regen Med. 2007 Jul-Aug;1(4):296-305. doi: 10.1002/term.40.
- 2022. "Evaluation of Outcomes With Umbilical Cord Allograft for Musculoskeletal Conditions Musculoskeletal Conditions". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03390920.
Frequently Asked Questions
Can patients sign up for this research project at this time?
"According to the latest update on clinicaltrials.gov, this particular study is not looking for new patients at the moment. This research was first made public on January 1st, 2022 but has not been updated since September 10th, 2021. Although this trial isn't currently recruiting, there are 1935 other trials that are still enrolling candidates." - Anonymous Online Contributor