Symptoms of CREST syndrome may not occur for more than 3 years after the traumatic injury and the syndrome is diagnosed 6 months to 2 years after trauma. The cause of chronic CREST syndrome is unknown but it is likely multifactorial. Treatment of CREST syndrome consists of a multimodality approach aimed at achieving a tight healing of the painful compartment, the prevention and the early treatment of bone deformities, and a correct surgical management of the wound.
There is not enough evidence to suggest that compression-sensitization treatment can be curative or that complete resolution of acute symptoms is possible with nonsurgical approaches in treatment of chronic exertional compartment syndrome.
Chronic exertional compartment syndrome treatment involves compression, elevation and pain alleviance. Although the first two are used most frequently, some patients do not require this or the medications required to manage the disease.
The American College of Rheumatology/European League Against Rheumatism recommends exercise in patients at risk be discontinued or increased with regard to the risk of developing the condition of chronic exertional compartment syndrome. We need to develop more effective prevention measures and therapies.
Exertional pain (dysaesthesia), numbness/atrophy of fingers and toes, local swelling and tenderness (Tinel sign), loss of grip strength and atrophy of muscles can be noted in CECS patients. A palpable bruit may be heard over the affected area during physical examinations. Patients may also have an abnormal neurological examination with absent ankle reflexes.
There is no significant association with the age of the patient as it has previously been thought. The incidence and severity of symptoms can be related to the duration of the exercise before the diagnosis, with the increase in duration of exercise increasing the severity of compartment syndrome.
BoNT has been shown to alleviate CECS symptoms to a reasonable degree, though the effectiveness has been limited in some studies from an uncontrolled prospective observational study. With further study, BoNT may prove a valuable adjunct in the treatment of these patients.
Chronic exertional compartment syndrome (CECS) is characterized by an onset of symptoms within 3-6 weeks and persistent or recurrent symptoms which can lead to significant alteration in performance and function. CECS affects a wide range of athletes, cyclists, laborers and office workers at all levels of fitness, but often presents in endurance athletes. Exercise must trigger the pain and trigger a series of biochemical and anatomic changes in the tissue that result in an enhanced pain threshold. CECS is a continuum of symptoms which can range from chronic pain that does not respond well to treatment to acute, debilitating exacerbation of pain during and after activity. There are several variables which seem to be responsible for this progression of symptoms.
botulinum toxin injection is frequently used as the first course of treatment for chronic compartment syndrome of the vastus medialis. The use of this agent alone and in combination with other treatments is dependent on the condition of the patient, the experience of each surgeon, and the available therapeutic modalities.
Botulinum toxin type A injection in a selected population of patients suffering from chronic compartment syndrome has not achieved satisfactory results. The use of the injection technique as proposed by Dr. R. F. Mazzaboni in his publication "Chronic compartment syndrome treated by intraoperative injection" does not appear to be effective.
Botulinum toxin should be proposed in cases of [chronic pain](https://www.withpower.com/clinical-trials/chronic-pain) of the peroneal region related to chronic compartment syndrome. The present study demonstrated a significant (P < 0.0001) improvement in the patient's pain and/or walking ability.
Overall, botulinum toxin injection was well received and may be an effective therapeutic option for many patients with CECS. However, more than one-third of the patients reported moderate to intense side-effects at intervals up to six months following their therapeutic injections, which may, in part, be explained by their own expectation of these effects. Moreover, a significant minority of patients continued to experience significant pain during exercise and, in some cases, exercise intolerance (i.e. exercise-induced anaemia) developed after their injections.