Non-Surgical Treatments for Compartment Syndrome
Trial Summary
Do I have to stop taking my current medications for this trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the treatment for compartment syndrome?
Research shows that botulinum toxin injections and gait retraining can be effective for treating chronic exertional compartment syndrome (CECS). Botulinum toxin has been used successfully in some cases, and changing running or marching techniques has shown promising results in improving symptoms.12345
Is botulinum toxin injection generally safe for humans?
Botulinum toxin injections have been used safely for various conditions, including spasticity in cerebral palsy and chronic exertional compartment syndrome, with some reports of mild adverse events. In a study of patients with cerebral palsy, 4% experienced severe adverse events, but overall, the treatment is considered to have a satisfactory safety profile.16789
How is the treatment for compartment syndrome different from other treatments?
This treatment for compartment syndrome is unique because it combines Botulinum Toxin Injection, which is a drug that relaxes muscles, with gait retraining exercises that can be done at home or under supervision. This approach is different from traditional surgical options and focuses on improving walking ability and muscle function without surgery.1011121314
What is the purpose of this trial?
This trial evaluates non-surgical treatments like gait retraining and botulinum toxin injections for highly active individuals with lower leg pain due to CECS. These treatments aim to reduce pain by changing movement patterns and relaxing muscles. Botulinum toxin injections have been used to treat spasticity in stroke patients and muscle imbalance syndromes in sports medicine.
Research Team
Jeffrey Leggit, MD
Principal Investigator
Uniformed Services University of the Health Sciences
Eligibility Criteria
This trial is for active duty service members who can't run 2 miles without leg pain, have trouble with physical training due to lower leg symptoms, and are fluent in English. They must be diagnosed with CECS of the anterior or lateral compartments but haven't had botulinum injections, compartment release surgery, recent limb injuries requiring medical intervention, gait retraining recently, or any allergies to botulinum toxin.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive non-surgical treatment options including gait retraining and botulinum toxin or saline injections
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Botulinum Toxin Injection
- Home Based Gait Retraining
- Saline Injection
- Supervised Gait Retraining
Find a Clinic Near You
Who Is Running the Clinical Trial?
Walter Reed National Military Medical Center
Lead Sponsor
Uniformed Services University of the Health Sciences
Collaborator