Polymer Skin Barrier for Sweaty Palms
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a new topical treatment for individuals with excessive sweating on their hands, known as primary palmar hyperhidrosis. The treatment, called Polymer Skin Barrier, uses a special adhesive to quickly block sweat glands, potentially outperforming current options that take longer to work and often have side effects. Individuals who have experienced sweaty palms for at least six months and find it impacts their daily life might be suitable for this study. The goal is to find a fast, effective, and safe way to manage this condition. As an unphased trial, this study offers a unique opportunity to explore an innovative treatment that could significantly improve daily life for those affected.
Will I have to stop taking my current medications?
You may need to stop certain medications before joining the trial. Specifically, if you are taking medications with systemic anticholinergic activity, centrally acting alpha-2 adrenergic agonists, or beta-blockers, you must have been on a stable dose for at least 4 months. Additionally, you cannot have taken Qbrexza, botulinum toxin, or undergone iontophoresis recently.
What prior data suggests that this polymer skin barrier is safe for treating sweaty palms?
Research has shown that cyanoacrylate (CA) tissue adhesives, the main ingredient in the Polymer Skin Barrier treatment, have been safely used in medical settings for a long time. These adhesives help close wounds and prevent infections. Two types of CA, n-Butyl and 2-Octyl, are commonly used in surgeries and are considered safe. However, some people might experience a skin reaction called allergic contact dermatitis, occurring in about 2.2% to 2.7% of cases when used on surgical wounds. The risk may be lower when applied to healthy skin, as it will be in this treatment.
The treatment is not yet approved as an antiperspirant, but its safety is supported by its long history of medical use. The Polymer Skin Barrier is expected to be affordable and work quickly. It should not harm the skin or affect grip, making it a promising option for those dealing with sweaty palms.12345Why are researchers excited about this trial?
Researchers are excited about the Polymer Skin Barrier treatment for sweaty palms because it offers a novel approach compared to traditional methods like antiperspirants, iontophoresis, or Botox injections. Unlike these standard treatments, which primarily aim to block or temporarily disable sweat glands, the Polymer Skin Barrier forms a protective layer on the skin's surface, potentially reducing sweat without affecting the underlying glands. This method may offer a less invasive and more convenient daily application, with the potential for quicker results over just a week.
What evidence suggests that this polymer skin barrier is effective for hyperhidrosis?
Research has shown that a special skin barrier, like the topical polymer treatment in this trial, can effectively reduce excessive sweating on the palms. One study found that improving the HDSS score by one point can cut sweat production by 50%, while a two-point improvement can reduce it by 80%. This suggests the treatment could significantly decrease sweatiness. The polymer treatment acts quickly, within seconds, and does not harm the skin or affect grip. Unlike some current treatments, it is affordable and provides fast results, making it a promising option for managing sweaty palms.13678
Who Is on the Research Team?
Mark J Miller, PhD
Principal Investigator
Miller Biosciences LLC
Adelaide A Hebert, MD
Principal Investigator
UTHealth McGovern Medical School-Houston and Children's Memorial Hermann Hospital-Houston
Are You a Good Fit for This Trial?
This trial is for individuals with excessive sweating of the palms, known as hyperhidrosis. It's suitable for those who haven't had success with standard treatments like antiperspirants or find them irritating. People looking for a fast-acting, non-invasive option may benefit.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening/Baseline
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive topical cyanoacrylate treatment once or twice daily for one week
Follow-up
Participants are monitored for safety and effectiveness after treatment via phone call and exit survey
What Are the Treatments Tested in This Trial?
Interventions
- Polymer Skin Barrier
Find a Clinic Near You
Who Is Running the Clinical Trial?
Miller Biosciences LLC
Lead Sponsor