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SRP + MM for Gum Disease

N/A
Recruiting
Led By Arif Salman, DDS
Research Sponsored by West Virginia University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
For periodontally-healthy participants: Diagnosis of healthy periodontium defined as ≤9% of sites bleeding on probing with absence of interproximal attachment loss and bone loss
For randomized participants: Have at least 20 natural teeth with a diagnosis of Periodontitis (stage II, III, or IV)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline to 2 months post procedure
Awards & highlights

Study Summary

This trial will study the effects of minocycline microspheres as an adjunct to scaling and root planing, in comparison to subjects who only receive scaling and root planing, and to subjects with healthy periodontal conditions.

Who is the study for?
This trial is for adults with at least 20 natural teeth who have been diagnosed with Periodontitis (stage II, III, or IV). It's also open to those with healthy gums. People can't join if they don't meet the specific dental health criteria set by the researchers.Check my eligibility
What is being tested?
The study is testing whether adding minocycline microspheres (MM) to standard gum disease treatment (scaling and root planing - SRP) changes the makeup and activity of bacteria under the gums compared to just SRP alone.See study design
What are the potential side effects?
Possible side effects from treatment may include discomfort during dental procedures, sensitivity in treated areas, and potential allergic reactions to minocycline for those sensitive to this medication.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
My gums are healthy with minimal bleeding and no bone loss.
Select...
I have at least 20 natural teeth and have been diagnosed with moderate to severe gum disease.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline to 2 months post procedure
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to 2 months post procedure for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Bleeding on Probing (SRP + MM)
Bleeding on Probing (SRP only)
Change in Clinical Attachment Loss (SRP + MM)
+5 more

Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: SRP + MMExperimental Treatment1 Intervention
Scaling and rooting planning in combination with minocycline microspheres
Group II: SRPActive Control1 Intervention
Scaling and rooting planning
Group III: Periodontally-Healthy SubjectsActive Control1 Intervention
No Intervention

Find a Location

Who is running the clinical trial?

West Virginia UniversityLead Sponsor
176 Previous Clinical Trials
60,169 Total Patients Enrolled
Bausch Health Americas, Inc.Industry Sponsor
262 Previous Clinical Trials
81,983 Total Patients Enrolled
Arif Salman, DDSPrincipal InvestigatorWest Virginia University

Media Library

Scaling and Root Planing (SRP) Clinical Trial Eligibility Overview. Trial Name: NCT05422742 — N/A
Gum Disease Research Study Groups: SRP, SRP + MM, Periodontally-Healthy Subjects
Gum Disease Clinical Trial 2023: Scaling and Root Planing (SRP) Highlights & Side Effects. Trial Name: NCT05422742 — N/A
Scaling and Root Planing (SRP) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05422742 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the current size of the participant cohort for this experiment?

"Affirmative. According to clinicaltrials.gov, the study is still in search of participants, with recruitment starting from October 15th 2021 and last updated on October 2nd 2022. 45 individuals are needed for this trial conducted at a solitary site."

Answered by AI

Are participants currently being enrolled into this experiment?

"Confirmed, clinicaltrials.gov reveals that this medical experiment is actively seeking participants after being initially posted on October 15th 2021. 45 patients are needed for the single location taking part in this trial and the information was last updated on October 2nd 2022."

Answered by AI

Who else is applying?

What state do they live in?
West Virginia
Maryland
How old are they?
65+
What site did they apply to?
West Virginia University
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria
Recent research and studies
clinicaltrials.govStudy
Influence of SRP With MM on the Composition and Functional Characteristics of Subgingival Microbiome Communities
Arif Salman 2021. "Influence of SRP With MM on the Composition and Functional Characteristics of Subgingival Microbiome Communities". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05422742.
All > Microbiome
~13 spots leftby Apr 2025
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