E-Cigarettes + Nicotine Therapy for Smoking Cessation
(CRESCENT Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial protocol does not specify whether you need to stop taking your current medications. However, if you are using prescription weight loss medication, you must have stopped it at least 30 days before joining the trial.
What data supports the effectiveness of the treatment E-Cigarettes + Nicotine Therapy for Smoking Cessation?
Is the combination of e-cigarettes and nicotine therapy safe for humans?
How is the treatment of e-cigarettes combined with nicotine therapy unique for smoking cessation?
This treatment is unique because it combines electronic cigarettes (e-cigarettes) with nicotine replacement therapy (NRT), potentially offering a more effective approach by using both methods together to help people quit smoking. This combination may provide a more comprehensive way to manage nicotine cravings compared to using either method alone.13111213
What is the purpose of this trial?
This project will investigate the effects of alternative nicotine products on smoking, weight gain, and related outcomes.
Eligibility Criteria
This trial is for adults over 21 who are obese (BMI ≥ 30), smoke at least 5 cigarettes a day, and have not tried to quit smoking or used weight loss medication recently. Participants need access to a Bluetooth-enabled device and must be willing to use e-cigarettes or nicotine replacement therapy for 8 weeks.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants are randomized to receive electronic cigarettes, nicotine replacement therapy, or no-product control for 8 weeks
Follow-up
Participants are monitored for smoking cessation, weight, and other health outcomes
Treatment Details
Interventions
- Electronic Cigarettes
- Nicotine replacement therapy
Find a Clinic Near You
Who Is Running the Clinical Trial?
Brown University
Lead Sponsor
National Institute of General Medical Sciences (NIGMS)
Collaborator