Renuvion for Loose Skin

No longer recruiting at 1 trial location
KA
CA
Overseen ByCrystal A Snyder, CCRP
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Apyx Medical
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to assess the Renuvion device's effects on skin quality by improving elasticity and hydration. It also estimates the biological age of the skin using DNA methylation. Participants will receive a lower facelift along with Renuvion treatment. This trial suits individuals planning a lower facelift, who are generally healthy and have not undergone previous facelift or neck lift procedures. As an unphased trial, it offers participants the opportunity to contribute to innovative research in skin rejuvenation.

Do I need to stop my current medications for the Renuvion trial?

The trial information does not specify if you need to stop taking your current medications. It's best to discuss your specific medications with the study team to get a clear answer.

What prior data suggests that the Renuvion device is safe for use in lower facelift procedures?

Research has shown that the Renuvion APR System, which uses helium plasma energy, is generally safe for improving skin appearance. In studies focused on loose skin around the neck, no serious side effects were linked to the device or the procedure, indicating that most patients tolerate the treatment well.

However, some risks exist. For example, helium could accidentally enter the surgical area, a condition known as helium embolism. These risks are rare and usually well-managed by doctors.

The Renuvion device has FDA clearance for certain cosmetic procedures, supporting its safety when used correctly. Overall, evidence indicates that this treatment is safe, with manageable risks.12345

Why are researchers excited about this trial?

Renuvion APR System is unique because it uses a combination of helium plasma and radiofrequency energy to tighten loose skin, particularly in the lower facelift area. Unlike traditional facelift surgeries that rely solely on surgical excision and repositioning of skin, Renuvion offers a minimally invasive approach, potentially leading to quicker recovery times and reduced scarring. Researchers are excited about this treatment because it promises precise targeting of the skin’s deeper layers, enhancing skin tightening and rejuvenation with less downtime than conventional surgical methods.

What evidence suggests that the Renuvion device is effective for improving skin elasticity and hydration?

Research has shown that the Renuvion APR System effectively tightens loose skin. In one study, patients experienced an average reduction in skin surface area of 22% after one month and 17% after three months. Another study found a 26% average improvement in skin tightness. Patients generally reported less loose skin and expressed high satisfaction with the results. In this trial, participants will undergo a procedure with the Renuvion APR System in the lower facelift area. These findings suggest that Renuvion can enhance skin quality and tightness without increasing complications.15678

Who Is on the Research Team?

ML

Melinda Lacerna, M.D.

Principal Investigator

LA Plastic Surgery & Dermatology

DH

David Holcomb, M.D.

Principal Investigator

Holcomb & Kreithen Plastic Surgery and MedSpa

Are You a Good Fit for This Trial?

This trial is for men and women aged 18-75 planning to have a lower facelift surgery. It's designed to assess the effects of the Renuvion APR System on skin quality, specifically elasticity and hydration, as well as estimating biological skin age.

Inclusion Criteria

I am in good or mild systemic disease health according to the ASA classification.
I plan to have a lower facelift, possibly including a neck lift, at the specified location.
I am willing to use birth control during the study.
See 6 more

Exclusion Criteria

Possesses a surgically implanted electronic device (i.e. pacemaker)
Serious mental health illness such as dementia or schizophrenia; psychiatric hospitalization in the past two years
Participation in any other investigational study within 30 days prior to consent and throughout study participation
See 10 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive a lower facelift surgery and treatment with the Renuvion APR System

1 day
1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment, including assessments of skin elasticity, hydration, and biological age estimation

180 days
Multiple visits (Day 1, 7, 14, 45, 90, 180)

What Are the Treatments Tested in This Trial?

Interventions

  • Renuvion APR System
Trial Overview The study tests the Renuvion APR System's impact on improving skin conditions like Cutis Laxa and Collagen Degeneration by measuring changes in collagen density, elastin levels, hydration factors, and DNA methylation after its use during facelift surgery.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: Procedure with the Renuvion APR System in lower facelift areaExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Apyx Medical

Lead Sponsor

Trials
10
Recruited
360+

Citations

Safety and Efficacy of Renuvion Helium Plasma to Improve ...One study showed an average skin surface area reduction of 22% and 17% at 1- and 3-month follow-up visits, respectively, and an average of 26% skin tightening ...
APYX MEDICAL CORPORATION ANNOUNCES TWO ...The authors reported that patients in the Renuvion group demonstrated improvements in abdominal skin laxity and excess skin, along with higher ...
Apyx Medical Announces Positive Outcomes from Two ...The studies reported improved skin laxity and higher satisfaction in patients treated with Renuvion, without increased complications. How many ...
CLINICAL TRIAL PROTOCOL NUMBER:APX-23-02 DATE: ...The Renuvion® APR Handpiece is indicated for use in subcutaneous dermatological and aesthetic procedures to improve the appearance of lax (loose) ...
5.pubmed.ncbi.nlm.nih.govpubmed.ncbi.nlm.nih.gov/39815024/
Efficacy of Renuvion Helium Plasma to Improve the ...Conclusions: Data showed a significantly greater improvement of abdominal skin laxity in patients treated with Renuvion compared to those who underwent ...
Use of Renuvion/J-Plasma Device for Certain Aesthetic ...The FDA cleared the Renuvion APR handpiece for coagulation of subcutaneous soft tissues following liposuction for aesthetic body contouring.
(PDF) Safety and Efficacy of Renuvion Helium Plasma to ...There were no serious adverse events reported as related to the study device or procedure. Conclusions: The data demonstrates benefit to ...
Helium Plasma Subdermal Tissue Contraction Method of ...Risk associated with the use of the Renuvion APR may include: helium embolism into the surgical site due to inadvertent introduction into the ...
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