Osteoarthritis Clinical Trials

OA studies recruiting patients for novel treatments. Filter by phase, distance, and inclusion criteria to find your perfect osteoarthritis clinical trial.

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periosteal electrical dry needling with no maintenance treatments

The purpose of this research is to treat patients with knee osteoarthritis (OA) with periosteal electric dry needling (PEDN). It is also to determine the optimal "maintenance" regiment (i.e. maintenance treatments, one maintenance treatment every other month, or one maintenance treatment p…

S-Adenosyl-L-Methionine (Sam-E)

The primary objective of this study is to demonstrate the feasibility of evaluating SAMe tolerability, analgesic benefits, and daily functional improvement in patients with osteoarthritis of the hands compared to placebo. The secondary objective of this study is to generate preliminary dat…

Revision Total Hip Arthroplasty

The primary objective is to establish the mean superior cup migration of the PINNACLE® Dual Mobility Construct using model-based RSA over the first two years post-implantation. The primary endpoint is the mean vertical subsidence (Y translation, also known as superior cup migration) at 2 y…

The purpose of this study is to test the OA Clinic-Community CARE Model (OA CARE) which will address all recommended components of knee/hip (osteoarthritis) OA care, include interventions for both patients and primary care providers (PCPs), and utilize a tailored approach that efficiently …

This multi-site study involving Northwestern Medicine, Beaumont Health, and Loyola Medicine seeks to answer the following question: do patients who undergo subscapularis (SSc) repair during reverse total shoulder arthroplasty (RSA) have better post-operative outcomes than patients who do n…

Long-Term Objective: Determine if high-frequency PEMF therapy reduces pain and improves function in patients with thumb carpometacarpal (CMC) joint osteoarthritis (OA) and if this is secondary to physiological changes. Study Design and Methods: This will be a randomized controlled pilot s…

This study aims to compare post-surgical outcomes of individuals who receive either a custom orthosis or prefabricated splint after carpometacarpal arthroplasty.

Ketorolac injection to the hand or wrist

Osteoarthritis (OA) and inflammatory conditions of the tendons and joints of the hand and wrist are common yet disabling diseases. Standard management utilizes conservative measures to minimize pain and improve function. Conservative pharmacological management commonly includes corticoster…

Phone-Based Walk With Ease

The objective of this study is to examine the short-term (6-weeks and 6 months) and long-term (1 year) effects of a phone-based version of Walk With Ease intervention.

The study is a multicentered, randomized, double-blinded, placebo-controlled study conducted on the unilateral knee of 120 patients. The study compares the effectiveness of an injection of a mesenchymal stem cell preparation from autologous bone marrow aspirate (BMA) to a corticosteroid co…

Implementation Strategy: Enhanced REP (enREP)

Implementing Group Physical Therapy (PT) for Veterans with Knee Osteoarthritis (OA): Function QUERI 2.0 (Group PT) aims to implement, evaluate and sustain Group PT in 16 VA sites using a type III effectiveness-implementation hybrid design framework, which will compare implementation strate…

Arthritis is a common condition in the United States, and a leading cause of pain and disability. Physical exercise is recommended for managing arthritis, but access to evidence-based exercise programs is limited, particularly in rural areas. Therefore, the investigators propose to evaluat…

Sustained Acoustic Device with 2.5% Diclofenac Patch

The purpose of this study is to compare Sustained Acoustic Medicine treatment to topical pain relief gel for the symptomatic management of knee osteoarthritis. The study will measure pain and function scores for patients undergoing treatment.

Dynamic Stability Exercise Program

Background. Arthritis is the leading cause of disability in the United States and osteoarthritis (OA) of the hand affects an estimated 25.6 US residents. OA of the thumb carpometacarpal (CMC) joint is the most disabling form of hand OA. Rehabilitation for persons with thumb CMC OA is recom…

Knee Brace + OPUM Digital Knee

OBJECTIVES: Physical activity has been established as an important component of rehabilitation for knee osteoarthritis (OA), and is often guided by a physical therapist.(1) Physical therapy for knee OA typically involves 1-3 sessions with a licensed physical therapist per week, for up to …

Carbon Fiber Custom Dynamic Orthosis (CDO)

The proposed study evaluates the effect of carbon fiber brace design on forces across the ankle. Research suggests that ankle arthritis develops following ankle fracture due, in part, to elevated forces on the cartilage. It is expected that carbon fiber braces can reduce forces in the ankl…

Zoledronic Acid Injection

The purpose of this study is to assess if a zoledronic acid injection can alter the trajectory of joint degeneration following an acute anterior cruciate ligament (ACL) injury.

This is a Phase 2a safety and efficacy study of XT-150 in adult participants experiencing back pain due to inflammation of the facet joint, also known as facet joint osteoarthritis (FJOA), and who are eligible for intra articular glucocorticoid injection, or radiofrequency ablation of medi…

Guardian Sport Rehabilitator knee brace

The purpose of this research is to help determine if use of the Guardian brace during prehab and post-op rehab after TKA can help improve functional outcomes and reduce the incidence of post-operative flexion contractures which reduce knee range of motion after surgery.

self-management strategies

Hip and knee osteoarthritis (OA) is a burden of disability in adults, with many seeking total joint arthroplasty (TJA) to reduce their symptoms. Almost 50% of people screened for TJA are referred for further rehabilitation rather than TJA. However, access to community-based rehabilitation …

Dextrose prolotherapy (DPT)

The purpose of this research is to learn more about treating Symptomatic Knee Osteoarthritis (OA) with an ultrasound-guided hypertonic dextrose injection. Researchers would like to determine best practice for injection frequency and effectiveness of the dextrose injection for symptomatic k…

Platelet Rich Plasma Injection

Shoulder arthroplasty provides successful improvement in pain and function for the treatment of end stage osteoarthritis (OA) of the shoulder in the older patient population (Sanchez 2008, Sampson 2010, Kon 2012, Fitzpatrick 2017). However, the optimal non-operative treatment for shoulder …

Anterior cruciate ligament (ACL) ruptures are very common knee injuries amongst youth involved in sports and are often treated through ACL reconstruction surgeries. Unfortunately, up to 50% of individuals who undergo ACL reconstruction develop post-traumatic osteoarthritis (PTOA) in their …

bupivacaine liposome injectable suspension

The purpose of the study is to compare magnitude of postsurgical analgesic effect in different groups following a single dose of study drug when administered via adductor canal block in subjects undergoing primary unilateral total knee arthroplasty.

Haptic Biofeedback from SageMotion Biofeedback System

This study is evaluating whether a surgery which reduces blood flow in a stomach artery leads to significant weightloss.

RAPTOR protocol: hybrid in-person + telehealth physical therapy services

This study is evaluating whether a hybrid in-person + telerehabilitation intervention is safe and effective for rural adults with knee osteoarthritis.

Embosphere Microspheres

This study is evaluating whether a surgery which reduces blood flow in a knee artery can help reduce pain in people with knee osteoarthritis.

Dorsal Root Ganglion Stimulation

This study is evaluating whether a surgery which stimulates a nerve can treat pain caused by arthritis.

This study is evaluating whether a single injection of a placental tissue particulate can improve pain and function in people with knee osteoarthritis.

Transcranial Magnetic Stimulation

This study is evaluating whether TMS can improve pain in people with knee osteoarthritis.

A Double-blind, Multi-Center, Prospective, Randomized Placebo-controlled Pilot Study Evaluating Intra-articular Injection of Axolotl Ambient Compared to Saline in Subjects with Ankle Osteoarthritis. The goal of this pilot study and subsequent pivotal trial is to evaluate the safety and eff…

This study is evaluating whether a drug can help people with knee pain.

Platelet Rich Plasma Injection

In this study, the investigators will be performing intra-articular platelet rich plasma (PRP) injections for patients experiencing pain related to osteoarthritis of the knee. The investigators will be following clinical outcomes, and how they relate to concentrations of the PRP samples as…

It is hypothesized that a single Intra-articular Injection of TTAX03, 100mg in 2mL of saline, will have more benefit with respect to the proportion of responders 12 weeks post-injection than an equal volume of saline, based on the OMERACT-OARSI responder criteria.

This study is evaluating whether semaglutide can help people lose weight.

Sustained Acoustic Device with 2.5% Diclofenac Patch

This study is evaluating whether ultrasound devices and common pain relief gel are usable for people with arthritis.

Corticosteroid Injection given in A-B order

Washington, United States

Washington, United States

18+

All Sexes

This study is evaluating whether a combination of social incentives and injections is more effective than injections alone at promoting physical activity and reducing pain and disability in people with knee osteoarthritis.

This study is evaluating whether a set of activities can improve physical function in people with knee osteoarthritis.

This study is evaluating whether a drug can reduce pain in people with osteoarthritis of the knee.

This study is evaluating whether a drug called ACP-044 can help reduce pain in people with osteoarthritis of the knee.

This study is evaluating whether a topical gel can help reduce pain in people with osteoarthritis.

NanoScope™ Operative Arthroscopy (Arthrex, Inc)

This study is evaluating whether a procedure can be used to confirm the presence of unicompartmental knee OA and guide patient management in the decision to perform UKA or TKA.

This study is evaluating whether a diet rich in anti-inflammatory foods can improve clinical and biological outcomes in people with rheumatoid arthritis.

This study is evaluating whether a new pain reliever is better than a placebo.

This study is evaluating whether daily treatment with THC, CBD, or THC plus CBD affects knee osteoarthritis pain and other related symptoms.

This study is evaluating whether a bone marrow injection can improve pain and function in people with hip osteoarthritis.

Expanded Intervention

This study is evaluating whether a telehealth physical therapy program can increase physical activity in adults with knee osteoarthritis.

Immediate 8-Week SOAR Program

This study is evaluating whether a set of exercises can improve knee strength and quality of life in people who have had a knee injury.

The pain experience and its associated mechanisms in people with knee osteoarthritis (OA) are known to be complex and multidimensional. The current understanding of OA pain mechanisms is incomplete, resulting in limited pain management strategies. There is high-quality evidence that sugges…

Gel-Bead embolization

This study is evaluating whether a surgery which reduces blood flow in a knee artery can help reduce pain and improve function in people with knee osteoarthritis.

This study is evaluating whether a diet and exercise program can help people with knee osteoarthritis.

This study is evaluating whether a 6-week individualized gait retraining program can improve knee load and symptoms in people with knee osteoarthritis.

Micro Fragmented Adipose Tissue

This study is evaluating whether a new treatment for osteoarthritis is better than the current standard treatment.

External focus of attention feedback

This study is evaluating whether a new way to provide feedback about the way people move can help prevent knee injuries.

POPOP (preoperative patient optimization program)

This study is evaluating whether a preoperative program of physical activity and nutrition can improve health and reduce the risk of complications for people with hip or knee arthritis.

Physical Activity Promotion

This study is evaluating whether a specific type of exercise may help prevent osteoarthritis in the knee.

Amniotic Fluid Injection

This is a Phase I/II Randomized Double-Blinded Standard of Care (Corticosteroid) vs. Sterile Amniotic Fluid for Osteoarthritis

This study evaluates the efficacy and safety of a single IA injection of various RTX doses, Zilretta or placebo for the treatment of pain due to moderate to severe osteoarthritis knee pain..

Experimental: Whole Body Vibration

Background: Post-traumatic knee osteoarthritis (PTOA) is a leading cause of medical separation from military service. Anterior cruciate ligament injury and surgical reconstruction (ACLR) incurs a high PTOA risk and is an ideal model for evaluating PTOA prevention strategies. Aberrant gait …

LNA043 Dosing Regimen A

This study is evaluating whether a drug called LNA043 can help people with knee osteoarthritis.

GLA:D program (Good Life with osteoArthritis in Denmark)

This study is evaluating whether a program designed to improve quality of life for individuals with osteoarthritis of the knee is feasible for implementation in West Virginia.

Concentrated bone marrow aspirate administration after Comprehensive Arthroscopic Management (CAM) surgical procedure.

This study is evaluating whether a specific type of blood cell treatment is safe for people.

This study is evaluating whether a combination of two drugs may help treat osteoarthritis.

Pentosan Polysulphate Sodium

The purpose of this study is to measure the duration of treatment effect and response to re-treatment with subcutaneous injections of pentosan polysulfate sodium (PPS) compared with placebo in adult participants with knee osteoarthritis (OA) pain. Study details include: The study duratio…

This study is evaluating whether a drug called canakinumab can help people with knee osteoarthritis.

Pentosan Polysulfate Sodium

The purpose of this study is to measure the change in pain and function with subcutaneous injections of pentosan polysulfate sodium (PPS) compared with subcutaneous injections of placebo in participants with knee osteoarthritis pain. Study details include: The study duration will be up t…

Joint Insights decision aid

Osteoarthritis (OA) of the knee constitutes a major public health problem. Treatment options for knee OA range from lifestyle changes to pharmacological management to total knee replacement surgery. As a "preference-sensitive" condition, management of OA of the knee is ideally suited for s…

This is a study involving people receiving care at the Michael E. DeBakey VA Medical Center, Houston Texas. We are studying people who have hand osteoarthritis (the most common form of arthritis that involves the hand) and testing treatments for the condition with the hope that we can help…

Low-dose/sustained-duration Fisetin

This study is evaluating whether a supplement may help treat knee osteoarthritis.

This study is evaluating whether a new treatment for osteoarthritis may be effective.

This study is evaluating whether a sleeve that reduces inflammation in the knee can improve mobility, function, and pain in people with knee osteoarthritis.

Plasma Rich in Growth Factor (PRGF) Supplementation

This study is evaluating whether a specific type of injection may help reduce pain for individuals with temporomandibular joint osteoarthritis.

This study is evaluating whether weight loss can help improve joint health for individuals with osteoarthritis.

Total Knee Replacement

This study is evaluating whether a robotic system may help surgeons perform knee replacements more accurately.

Angel Concentrated Platelet Rich Plasma (cPRP) System

This study is evaluating whether a bone marrow concentrate may help improve osteoarthritis of the knee.

This study is evaluating whether a new pathway can help rural patients with knee osteoarthritis.

BEST™ HVPC microcurrent electrical stimulation Pro-Sport Ultra® device

This study is evaluating whether a new electrical stimulation device may help reduce pain and increase activity level in patients with knee osteoarthritis.

Phoenix Thera-Lase System

Nellis Air Force Base, NV

Nellis Air Force Base, NV

18+

All Sexes

This study is evaluating whether low level laser therapy may help reduce pain and improve functionality for individuals with hand osteoarthritis.

Foot rotation modification

This study is evaluating whether a walking modification program can improve pain and function in people with knee osteoarthritis.

Diclofenac sodium active topical patch

This study is evaluating whether a new drug may help reduce pain for individuals with osteoarthritis.

Embozene MicroSpheres

The purpose of this clinical trial is to determine whether genicular artery embolization (GAE) is an effective way to treat knee pain from osteoarthritis. Pain from arthritis is often due to underlying inflammation in the joint. The inflammation is associated with increased abnormal blood …

Mind-body exercise and education

This proposal aims to provide crucial knowledge about the neurobiological mechanisms underlying Tai Chi mind-body therapy for knee osteoarthritis (OA). The central mechanism of knee OA pain will be investigated using brain imaging technology to evaluate how brain function and structure cha…

Stem Cell Support Formula

This study is evaluating whether a nutritional supplement may help improve joint health and function for individuals with knee osteoarthritis.

This study is evaluating whether a robotic exoskeleton may help improve mobility for individuals with impaired mobility.

This study is evaluating whether a combination of three plant extracts may help improve the body's ability to protect itself against stress.

Amniotic Suspension Allograft

This study is evaluating whether a common pain reliever may help treat knee pain associated with osteoarthritis.