150 Participants Needed

PRP vs Corticosteroids for Basal Joint Osteoarthritis

JA
NM
Overseen ByNaem Mufarreh
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Kettering Health Network

Trial Summary

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What data supports the effectiveness of the treatment for basal joint osteoarthritis?

Research shows that both corticosteroids and platelet-rich plasma (PRP) are effective in reducing pain and improving function in conditions like knee osteoarthritis and shoulder periarthritis. PRP may offer better long-term outcomes, while corticosteroids provide quicker short-term relief.12345

Is it safe to use PRP and corticosteroid injections in humans?

Both PRP and corticosteroid injections are generally safe for treating various conditions like shoulder pain, knee osteoarthritis, and lumbar spondylosis. Studies have shown no major complications and similar minor complication rates for both treatments.12356

How does the treatment of PRP compare to corticosteroids for osteoarthritis?

PRP (Platelet-Rich Plasma) injections may offer longer-lasting relief compared to corticosteroid injections for osteoarthritis, as they are suggested to be more effective over time, although both treatments are effective in reducing pain and improving function in the short term.35678

What is the purpose of this trial?

Single blinded PRP vs. Corticosteroid vs. Placebo (normal saline) intra-articular injection for basal joint arthritis.

Eligibility Criteria

This trial is for people with early to moderate osteoarthritis in the basal joint of the thumb. It's not suitable for those with fibromyalgia, inflammatory diseases, bone tumors, certain wrist conditions like DeQuervain's tenosynovitis recently treated or advanced arthritis as per Eaton stage 4. Pregnant or terminally ill patients and those who've had a corticosteroid injection in the past year at the affected site are also excluded.

Inclusion Criteria

My arthritis in the thumb joint is at an early to moderate stage.

Exclusion Criteria

My thumb joint arthritis is severe (Stage 4).
I have Pressier disease, Kienbock's, or avascular necrosis of the scaphoid.
You are pregnant or have a terminal illness.
See 6 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive intra-articular injections of either PRP, corticosteroid, or placebo for basal joint arthritis

6-8 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment

1 year

Treatment Details

Interventions

  • Corticosteroid injection
  • Normal Saline
  • Platelet Concentrate
Trial Overview The study tests three treatments: platelet concentrate (PRP), corticosteroid injections, and placebo (normal saline) injected into the joint. Participants won't know which treatment they're getting but will be randomly assigned to one of these options to compare effectiveness.
Participant Groups
3Treatment groups
Experimental Treatment
Active Control
Placebo Group
Group I: PRPExperimental Treatment1 Intervention
Intra-articular injection of platelet rich plasma.
Group II: CorticosteroidActive Control1 Intervention
Intra-articular injection of kenalog.
Group III: Normal SalinePlacebo Group1 Intervention
Intra-articular injection of normal saline

Corticosteroid injection is already approved in United States, European Union, Canada for the following indications:

🇺🇸
Approved in United States as Corticosteroids for:
  • Allergic reactions
  • Asthma
  • COPD
  • Rheumatoid arthritis
  • Osteoarthritis
  • Bursitis
  • Tendonitis
  • Skin conditions
  • Eye conditions
  • Gastrointestinal disorders
🇪🇺
Approved in European Union as Corticosteroids for:
  • Allergic reactions
  • Asthma
  • COPD
  • Rheumatoid arthritis
  • Osteoarthritis
  • Bursitis
  • Tendonitis
  • Skin conditions
  • Eye conditions
  • Gastrointestinal disorders
🇨🇦
Approved in Canada as Corticosteroids for:
  • Allergic reactions
  • Asthma
  • COPD
  • Rheumatoid arthritis
  • Osteoarthritis
  • Bursitis
  • Tendonitis
  • Skin conditions
  • Eye conditions
  • Gastrointestinal disorders

Find a Clinic Near You

Who Is Running the Clinical Trial?

Kettering Health Network

Lead Sponsor

Trials
20
Recruited
1,700+

Findings from Research

Corticosteroid injections effectively modulate inflammation and maintain synovial homeostasis in shoulder pain, as shown by their regulation of pro-inflammatory and anti-inflammatory cytokines.
When combined with platelet-rich plasma (PRP), corticosteroids enhance the regulation of certain inflammatory markers without interfering with the corticosteroid's effects, suggesting a synergistic benefit in treating inflammation.
Effects of corticosteroids and platelet-rich plasma on synoviocytes in IL-1ß-induced inflammatory condition.Yea, JH., Shin, S., Yoon, KS., et al.[2022]
In a study of 81 patients with tennis elbow, both platelet-rich plasma (PRP) and methylprednisolone injections resulted in similar reductions in pain and functional disability after 12 months, indicating comparable efficacy.
Patients in both treatment groups reported similar levels of satisfaction with their treatment, suggesting that either PRP or methylprednisolone can be effective options for managing tennis elbow.
Clinical efficacy of Platelet-Rich Plasma versus local Methylprednisolone Injection in Lateral Epicondylitis.Shaikh, SA., Tahir, M., Ahmed, N.[2023]
In a study involving 29 patients with bilateral knee osteoarthritis, both platelet-rich plasma (PRP) and corticosteroid injections were found to effectively improve pain, stiffness, and function over a six-month period.
While PRP showed slightly better results than corticosteroids at the six-month mark, there was no statistically significant difference between the two treatments, indicating that both are viable options for managing knee osteoarthritis.
Double-Blind Randomized Controlled Trial Comparing Platelet-Rich Plasma With Intra-Articular Corticosteroid Injections in Patients With Bilateral Knee Osteoarthritis.Pretorius, J., Nemat, N., Alsayed, A., et al.[2022]

References

Effects of corticosteroids and platelet-rich plasma on synoviocytes in IL-1ß-induced inflammatory condition. [2022]
Clinical efficacy of Platelet-Rich Plasma versus local Methylprednisolone Injection in Lateral Epicondylitis. [2023]
Double-Blind Randomized Controlled Trial Comparing Platelet-Rich Plasma With Intra-Articular Corticosteroid Injections in Patients With Bilateral Knee Osteoarthritis. [2022]
Comparison of Clinical and Functional Outcomes after Platelet-Rich Plasma Injection and Corticosteroid Injection for the Treatment of de Quervain's Tenosynovitis. [2023]
Comparison of the Efficacy of Platelet-Rich Plasma (PRP) and Local Corticosteroid Injection in Periarthritis Shoulder: A Prospective, Randomized, Open, Blinded End-Point (PROBE) Study. [2022]
Platelet-Rich Plasma Versus Corticosteroid Injection for Lumbar Spondylosis and Sacroiliac Arthropathy: A Systematic Review of Comparative Studies. [2023]
Intra-articular platelet-rich plasma injections versus intra-articular corticosteroid injections for symptomatic management of knee osteoarthritis: systematic review and meta-analysis. [2021]
Intra-Articular Injection of Platelet-Rich Plasma Is More Effective than Hyaluronic Acid or Steroid Injection in the Treatment of Mild to Moderate Knee Osteoarthritis: A Prospective, Randomized, Triple-Parallel Clinical Trial. [2023]
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