Naproxen 500 Mg for Osteoarthritis, Knee

Phase-Based Progress Estimates
3
Effectiveness
3
Safety
Northwestern University Feinberg School of Medicine, Chicago, IL
Osteoarthritis, Knee+1 More
Naproxen 500 Mg - Drug
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This is a pilot study with a 4-period double-cross-over design evaluating a treatment with non-steroidal anti-inflammatory drugs (NSAIDs) in people with painful knee osteoarthritis.

Eligible Conditions

  • Osteoarthritis, Knee

Treatment Effectiveness

Effectiveness Progress

3 of 3
This is further along than 93% of similar trials

Other trials for Osteoarthritis, Knee

Study Objectives

1 Primary · 0 Secondary · Reporting Duration: baseline to end of 14 day treatment period

Day 14
KOOS
ODI
PANAS questionnaire
PDQ
QST
mean of one week's daily pain ratings on an NRS scale

Trial Safety

Safety Progress

3 of 3
This is further along than 85% of similar trials

Other trials for Osteoarthritis, Knee

Trial Design

2 Treatment Groups

Cross-over Treatment: Initial treatment with naproxen
1 of 2
Cross-over Treatment: Initial treatment with placebo
1 of 2
Experimental Treatment

12 Total Participants · 2 Treatment Groups

Primary Treatment: Naproxen 500 Mg · Has Placebo Group · Phase 4

Cross-over Treatment: Initial treatment with naproxenExperimental Group · 2 Interventions: Naproxen 500 Mg, Placebo · Intervention Types: Drug, Drug
Cross-over Treatment: Initial treatment with placeboExperimental Group · 2 Interventions: Naproxen 500 Mg, Placebo · Intervention Types: Drug, Drug
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Naproxen 500 Mg
2018
N/A
~70
Placebo
1995
Completed Phase 3
~2670

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline to end of 14 day treatment period
Closest Location: Northwestern University Feinberg School of Medicine · Chicago, IL
Photo of Chicago 1Photo of Chicago 2Photo of Chicago 3
2011First Recorded Clinical Trial
8 TrialsResearching Osteoarthritis, Knee
144 CompletedClinical Trials

Who is running the clinical trial?

Northwestern UniversityLead Sponsor
1,421 Previous Clinical Trials
717,365 Total Patients Enrolled
9 Trials studying Osteoarthritis, Knee
1,276 Patients Enrolled for Osteoarthritis, Knee
Thomas J Schnitzer, MD, PhDPrincipal InvestigatorNorthwestern University
9 Previous Clinical Trials
310 Total Patients Enrolled
1 Trials studying Osteoarthritis, Knee
40 Patients Enrolled for Osteoarthritis, Knee

Eligibility Criteria

Age 18+ · All Participants · 10 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You are a male or female >40 years of age.
You have had average or more pain in your knee for at least 4 weeks.
You have a cellphone and/or access to a computer and are able to utilize the eDiary as directed.
You are taking the study drug and have been on a stable dose for at least 4 weeks.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.