This trial is evaluating whether 0.08 BAC Alcohol will improve 16 primary outcomes and 5 secondary outcomes in patients with Hashish Abuse. Measurement will happen over the course of Baseline and post drug administration at: 30 min; 2.5 hours.
This trial requires 12 total participants across 4 different treatment groups
This trial involves 4 different treatments. 0.08 BAC Alcohol is the primary treatment being studied. Participants will be divided into 4 treatment groups. Some patients will receive a placebo treatment. The treatments being tested are in Phase < 1 and are in the first stage of evaluation with people.
"Hashish abuse, also known as hashish ingestion, is a harmful behaviour linked to the abuse of drugs, particularly cannabis, cocaine, and amphetamine. It is characterized by excessive and often dangerous use." - Anonymous Online Contributor
"The use of hashish in small quantities is considered addictive, as reflected in the prevalence of hashish abuse. Hashish abusers may exhibit altered consciousness, dizziness, seizures, depression, irritability, hallucinations and paranoid psychosis. Such symptoms may be caused by intoxication or drug withdrawal. The symptoms are also sometimes exacerbated by alcohol or other drugs." - Anonymous Online Contributor
"Different strategies are recommended for treatment of hashish abuse. There are no convincing data for propelling the use of psychoactive drugs in modern society. In contrast, the data support a non-medical and non-surgical form of psychosurgery. It is recommended that the psychiatrist first make an attempt at pharmacologic or behavioural methods, and if no satisfactory results are obtained, then proceed to psychosurgical or neurosurgical interventions." - Anonymous Online Contributor
"Many marijuana abusers suffer a severe bout or series of severe bouts of paranoia, anxiety, and depression. They are often addicted to LSD and occasionally to PCP and amphetamines. Marijuana addiction is cured only when the user accepts the fact that marijuana is not the best medicine for his or her problem, and this usually takes several years. A short bout of LSD or amphetamines can often be used to abort a severe cannabis-induced paranoid reaction. Cannabis use by itself can induce severe psychosis. This fact was not mentioned by any of the psychotherapists." - Anonymous Online Contributor
"About 0.9 million persons between age 1 and 35 years have reported hashish abuse at least once in the past year. This represents 1.1% of U.S. persons aged 1 to 35 years. However, of those persons who have reported hashish abuse, 4.3% believe that they have used hashish in the past month. This results in hashish use in about three quarters of those who say they use hashish in the past month. However, the prevalence of hashish use among those who report hashish use in the past month remains largely unknown. These data highlight the need for improved health services aimed at the prevention of alcohol use and the reduction of risk behaviour for drug involvement among adolescents." - Anonymous Online Contributor
"Hashish abuse seems to have its roots in multiple factors. However, hashish abuse is commonly conceptualized as being an internal urge that people are unable to resist. It is believed that this inclination may result from a genetic susceptibility." - Anonymous Online Contributor
"Results show that drinking alcohol does not produce a more relaxed or comfortable state of mind, and may even produce an opposite effect. The alcohol may cause a heightened anxiety-stress response, resulting in a greater desire to move about and to initiate sexual activity, and also to become irritable and prone to tantrums and physical aggression." - Anonymous Online Contributor
"There is a significant difference between gender and average age hashish abusers first start smoking or drinking. The higher the age at which these behaviors start, there will be greater harm done on the kidneys by hashish abuse." - Anonymous Online Contributor
"Hashish may be a legitimate recreational addiction but in this study, there seems to be no effective treatment. Results from a recent paper have not yet been published. However, there seems to be some potential: a study showed that using "Passiflora incarnata" and "Passiflora malincana" in conjunction with an E.C.A. was efficacious in reducing acute cannabis abuse." - Anonymous Online Contributor
"Results from a recent paper provides some evidence for a familial pattern of adolescent hashish abuse, with higher frequency of marijuana use during the same period. There was no correlation between the frequency of current marijuana usage and age at first marijuana use." - Anonymous Online Contributor
"Although hashish (and cannabis) consumption is a social issue with significant consequences for health, current knowledge about hashish abuse among people who have been diagnosed with mental disorders is limited to anecdotal information only. Therefore, there is limited knowledge on the most recent research on hashish use." - Anonymous Online Contributor
"[Most of the (0.08 % alcohol) studies in which patients participated were of low or moderate methodological quality according to the Cochrane Handbook] (http://wwwnsm.org.au/publication_handbooks/cochranehandbook/2008/02_CochraneHandbook_Part1/CochraneHandbook-Part1.pdf). These shortcomings are similar to those found in previous studies in which patients participated, highlighting the need to improve the methodological rigor of all clinical trials involving alcohol. Patients should carefully consider the health and social circumstances of their condition, weigh the risks and potential benefits of a specific study and consult with their healthcare professional before participating." - Anonymous Online Contributor