cRFA for Osteoarthritis of the Knee

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
UC Davis Health, Sacramento, CAOsteoarthritis of the KneecRFA - Procedure
Eligibility
35 - 99
All Sexes
What conditions do you have?
Select

Study Summary

This trial will compare the efficacy of using cooled radiofrequency ablation guided by fluoroscopy versus ultrasound in treating knee osteoarthritis.

Eligible Conditions
  • Osteoarthritis of the Knee

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

4 Primary · 5 Secondary · Reporting Duration: The subjects will perform the OARSI-recommended performance-based functional tests at the baseline, three month, and six month time periods.

Month 24
Numeric Pain Rating Scale
PROMIS - Depression
PROMIS - Pain Interference
Western Ontario and McMaster Universities Arthritis Index (WOMAC)
The subjects will perform the OARSI-recommended performance-based functional tests at the baseline, three month, and six month time periods.
30-Second Chair Stand Test
40m Fast Paced Walk Test
Six Minute Walk Test
Stair Climb Test
Timed Up and Go Test48

Trial Safety

Safety Progress

1 of 3

Trial Design

2 Treatment Groups

Subjects with knee OA using ultrasound for cRFA intervention
1 of 2
Subjects with knee OA using fluoroscopy for cRFA intervention
1 of 2

Experimental Treatment

90 Total Participants · 2 Treatment Groups

Primary Treatment: cRFA · No Placebo Group · N/A

Subjects with knee OA using ultrasound for cRFA intervention
Procedure
Experimental Group · 1 Intervention: cRFA · Intervention Types: Procedure
Subjects with knee OA using fluoroscopy for cRFA intervention
Procedure
Experimental Group · 1 Intervention: cRFA · Intervention Types: Procedure

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: the subjects will perform the oarsi-recommended performance-based functional tests at the baseline, three month, and six month time periods.

Who is running the clinical trial?

University of California, DavisLead Sponsor
853 Previous Clinical Trials
5,017,635 Total Patients Enrolled
1 Trials studying Osteoarthritis of the Knee
9 Patients Enrolled for Osteoarthritis of the Knee
American Medical Society for Sports Medicine Collaborative Research NetworkUNKNOWN
University of FloridaLead Sponsor
1,260 Previous Clinical Trials
699,310 Total Patients Enrolled
6 Trials studying Osteoarthritis of the Knee
588 Patients Enrolled for Osteoarthritis of the Knee
Daniel Herman, MDPrincipal InvestigatorUniversity of California, Davis

Eligibility Criteria

Age 35 - 99 · All Participants · 4 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have been diagnosed with osteoarthritis (OA) in one or both of your knees based on the standards set by the American College of Rheumatology.
You experience pain with a score of at least four on most or all days in the past week based on your self-report.
You have been experiencing significant pain for at least three months and have tried different types of treatments, such as medications, physical therapy, and injections, but they haven't worked. If you have pain in both knees, only the knee that is causing the most discomfort will be studied.

Frequently Asked Questions

What demographic is eligible for enrolling in this investigation?

"This medical study is seeking 90 participants, aged 35-99, suffering from knee osteoarthritis. To be considered eligible for the trial they must meet all of the following criteria: 1) diagnosis in accordance with American College of Rheumatology guidelines; 2) Kellgren-Lawrence score between two and four; 3) pain intensity reported as a minimum NPRS score of 4 on most days during the past week; 4) resistant to conventional treatments that may include medications (acetaminophen/NSAIDs/opioids), physical therapy or intra-articular injections (corticosteroids/hyaluronic acid" - Anonymous Online Contributor

Unverified Answer

Is geriatric participation encouraged for this research trial?

"According to the eligibility standards of this clinical trial, individuals must be between 35 and 99 years old." - Anonymous Online Contributor

Unverified Answer

In what maximum capacity are individuals participating in this research endeavor?

"This study necessitates the recruitment of 90 qualified patients. Potential applicants can come from UC Davis Health in Sacramento, California and UF and Shands Orthopaedics and Sports Medicine Institute in Gainesville, Florida." - Anonymous Online Contributor

Unverified Answer

Are there vacancies in this medical experiment for participants?

"Affirmative. Clinicaltrials.gov offers evidence that this clinical research, originally published on February 2nd 2022, is actively enrolling participants. 90 individuals must be recruited across 3 distinct sites for the trial to continue as planned." - Anonymous Online Contributor

Unverified Answer

What are the expected outcomes of this experiment?

"The primary measure of success for this study, assessed over a 24-month timeframe, is the Pain Interference score as determined by PROMIS. Secondary measures will observe patient performance in the 30-second Chair Stand Test (maximum repetitions within thirty seconds), 40m Fast Paced Walk Test (time to complete 4x10m walk) and Six Minute Walk Test (maximal distance covered)." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.