Anti-inflammatory Diet for Osteoarthritis
Trial Summary
Do I have to stop taking my current medications for the trial?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you plan to change your systemic therapy or have used corticosteroids, intra-articular injections, fish oils, or glucosamine in the past 3 months.
What data supports the effectiveness of the treatment Anti-inflammatory Diet for Osteoarthritis?
Is the anti-inflammatory diet safe for humans?
The anti-inflammatory diet, including the Mediterranean diet, is generally considered safe for humans and has been associated with various health benefits, such as reducing the risk of heart disease, diabetes, and obesity. It emphasizes plant-based foods, healthy fats like olive oil, and limited meat consumption, which are linked to its safety and positive effects.16789
How does the Anti-inflammatory Diet treatment differ from other treatments for osteoarthritis?
The Anti-inflammatory Diet, also known as the Mediterranean Diet, is unique because it focuses on eating plant-based foods, using olive oil as the main fat source, and consuming limited meat, which may help reduce inflammation and pain in osteoarthritis. Unlike typical medications, this diet leverages natural anti-inflammatory properties found in foods like extra virgin olive oil, which contains compounds that can help manage symptoms.1471011
What is the purpose of this trial?
In a previous exploratory study, the investigators observed an effect on disease activity outcomes of anti-inflammatory diet. The investigators also observed change in microbiome and circulating metabolites. The current study will determine whether or not the addition of anti-inflammatory diet improves the clinical outcomes in participants with Osteoarthritis, and the role of microbiome and circulating metabolites.
Eligibility Criteria
This trial is for individuals with one-sided symptomatic knee osteoarthritis who haven't altered their treatment in the last 3 months. They should be interested in dietary changes and able to attend follow-ups. Excluded are those on recent steroids/injections, changing physical activity or diet, smokers, severe knee damage, rheumatoid arthritis, abnormal blood tests, or other conditions affecting nutrition study participation.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants follow an anti-inflammatory or healthy diet to assess its effect on osteoarthritis outcomes
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Anti-inflammatory Diet
- Healthy Diet
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, San Diego
Lead Sponsor