30 Participants Needed

Anti-inflammatory Diet for Knee Osteoarthritis

MG
Overseen ByMonica Guma, MD, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of California, San Diego
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications, but it requires that you haven't changed your treatment in the last 3 months. This suggests you may need to continue your current medications without changes.

What data supports the effectiveness of the Anti-inflammatory Diet for Knee Osteoarthritis treatment?

Research shows that following a Mediterranean diet, which is similar to the anti-inflammatory diet, can help reduce inflammation and improve symptoms in conditions like rheumatoid arthritis and multiple sclerosis. This suggests it might also be beneficial for knee osteoarthritis.12345

Is the anti-inflammatory diet safe for humans?

The Mediterranean diet, which is similar to the anti-inflammatory diet, has been studied in people with rheumatoid arthritis and is generally considered safe. It has shown benefits like reduced disease activity and improved gut health without reported safety concerns.13467

How does the ITIS diet treatment for knee osteoarthritis differ from other treatments?

The ITIS diet, also known as the Supercharged Mediterranean Diet, is unique because it focuses on anti-inflammatory foods to manage knee osteoarthritis, unlike traditional treatments that may rely on medication or weight loss alone. This diet emphasizes the balance of dietary fats, particularly omega-3 and omega-6 fatty acids, which have anti-inflammatory effects that can help reduce joint pain and stiffness.138910

What is the purpose of this trial?

To study the effect of anti-inflammatory diet on clinical and biological outcomes in patients with knee osteoarthritis

Eligibility Criteria

This trial is for individuals diagnosed with knee osteoarthritis who haven't changed their treatment in the past three months. It's not suitable for those with food allergies or pregnant women.

Inclusion Criteria

I have knee osteoarthritis and my treatment hasn't changed in the last 3 months.

Exclusion Criteria

History of food allergies
Pregnancy

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants follow an anti-inflammatory (ITIS) diet for 28 days

4 weeks

Follow-up

Participants are monitored for changes in pain and biological markers after dietary intervention

4 weeks

Treatment Details

Interventions

  • ITIS diet
Trial Overview The study investigates the impact of an anti-inflammatory diet, referred to as ITIS diet, on both clinical outcomes and biological markers in patients suffering from knee osteoarthritis.
Participant Groups
1Treatment groups
Experimental Treatment
Group I: ITIS dietExperimental Treatment1 Intervention
anti-inflammatory (ITIS) diet for 28 days

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of California, San Diego

Lead Sponsor

Trials
1,215
Recruited
1,593,000+

Findings from Research

In a 12-week randomized trial involving 154 overweight and obese patients with rheumatoid arthritis, the Mediterranean diet (MD) significantly reduced disease activity scores (DAS 28) compared to a low-fat high-carbohydrate diet and control group, indicating better management of RA symptoms.
The MD led to a 76% reduction in DAS 28 scores, demonstrating its effectiveness in reducing pain and inflammation in RA patients, regardless of weight loss outcomes.
Dietary Pattern or Weight Loss: Which One Is More Important to Reduce Disease Activity Score in Patients with Rheumatoid Arthritis? A Randomized Feeding Trial.Sadeghi, A., Tabatabaiee, M., Mousavi, MA., et al.[2023]
In a study of 180 patients with relapsing-remitting multiple sclerosis (RRMS), following a modified Mediterranean diet (mMeD) for 6 months significantly reduced dietary inflammatory index (DII) scores, indicating improved dietary inflammation levels.
The mMeD also led to a notable decrease in fatigue severity, as measured by the Modified Fatigue Impact Scale (MFIS), while the traditional Iranian diet (TID) showed no significant changes in either dietary inflammation or fatigue levels.
Modified Mediterranean diet v. traditional Iranian diet: efficacy of dietary interventions on dietary inflammatory index score, fatigue severity and disability in multiple sclerosis patients.Bohlouli, J., Namjoo, I., Borzoo-Isfahani, M., et al.[2022]
In a study of 4,330 participants over 4 years, higher adherence to the Mediterranean diet was linked to a lower risk of worsening knee pain, suggesting potential benefits for individuals at risk of knee osteoarthritis (OA).
Among those free from symptomatic knee OA at the start, greater adherence to the Mediterranean diet was associated with a 9% reduced risk of developing symptomatic knee OA during the follow-up period.
Mediterranean diet and knee osteoarthritis outcomes: A longitudinal cohort study.Veronese, N., Koyanagi, A., Stubbs, B., et al.[2021]

References

Dietary Pattern or Weight Loss: Which One Is More Important to Reduce Disease Activity Score in Patients with Rheumatoid Arthritis? A Randomized Feeding Trial. [2023]
Modified Mediterranean diet v. traditional Iranian diet: efficacy of dietary interventions on dietary inflammatory index score, fatigue severity and disability in multiple sclerosis patients. [2022]
Mediterranean diet and knee osteoarthritis outcomes: A longitudinal cohort study. [2021]
Adherence to Mediterranean diet and patient perception of rheumatoid arthritis. [2021]
An experimental study of a Mediterranean diet intervention for patients with rheumatoid arthritis. [2022]
Impact of Mediterranean Diet on Disease Activity and Gut Microbiota Composition of Rheumatoid Arthritis Patients. [2020]
The Mediterranean diet, and not dietary inflammatory index, is associated with rheumatoid arthritis disease activity, the impact of disease and functional disability. [2023]
Effects of a Mediterranean Diet Compared with the Low-Fat Diet on Patients with Knee Osteoarthritis: A Randomized Feeding Trial. [2022]
The effect of an anti-inflammatory in comparison with a low caloric diet on physical and mental health in overweight and obese women with knee osteoarthritis: a randomized clinical trial. [2023]
10.United Statespubmed.ncbi.nlm.nih.gov
The dietary treatment of inflammatory arthritis: case reports and review of the literature. [2005]
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