Metastasectomy for Prostate Cancer

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Huntsman Cancer Institute/University of Utah, Salt Lake City, UTProstate Cancer+5 MoreMetastasectomy - Procedure
Eligibility
18+
Male
What conditions do you have?
Select

Study Summary

This trial is testing whether surgery and radiation therapy are more effective than just radiation therapy in treating patients with prostate cancer that has returned or spread.

Eligible Conditions
  • Prostate Cancer
  • Metastatic Lymph Node Cancer
  • Oligometastasis
  • Prostate Adenocarcinoma
  • Prostate Specific Antigen Failure
  • Bone Metastasis

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

1 Primary · 6 Secondary · Reporting Duration: Up to 3 years

Month 6
Prostate-specific antigen (PSA) response rate
Year 3
PSA progression-free survival (PFS)
Year 3
Time to disease recurrence
Year 3
Time to antiandrogen therapy (ADT)
Up to 3 years
Assess impact of study treatment on Change in quality of life over 3 years
Incidence of adverse events
Rate of undetectable PSA

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Trial Design

3 Treatment Groups

Arm A (radiation therapy)
1 of 3
Arm C (salvage oligometastasectomy, radiation therapy)
1 of 3
Arm B (salvage oligometastasectomy)
1 of 3

Experimental Treatment

40 Total Participants · 3 Treatment Groups

Primary Treatment: Metastasectomy · No Placebo Group · Phase 2

Arm A (radiation therapy)Experimental Group · 4 Interventions: Hypofractionated Radiation Therapy, Questionnaire Administration, Stereotactic Body Radiation Therapy, Quality-of-Life Assessment · Intervention Types: Radiation, Other, Radiation, Other
Arm C (salvage oligometastasectomy, radiation therapy)Experimental Group · 6 Interventions: Hypofractionated Radiation Therapy, Questionnaire Administration, Metastasectomy, Intensity-Modulated Radiation Therapy, Stereotactic Body Radiation Therapy, Quality-of-Life Assessment · Intervention Types: Radiation, Other, Procedure, Radiation, Radiation, Other
Arm B (salvage oligometastasectomy)Experimental Group · 3 Interventions: Questionnaire Administration, Metastasectomy, Quality-of-Life Assessment · Intervention Types: Other, Procedure, Other
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Hypofractionated Radiation Therapy
2016
Completed Phase 2
~20
Intensity-Modulated Radiation Therapy
2010
Completed Phase 3
~1680
Stereotactic Body Radiation Therapy
2019
Completed Phase 2
~650

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: up to 3 years

Who is running the clinical trial?

University of UtahLead Sponsor
1,009 Previous Clinical Trials
1,787,402 Total Patients Enrolled
8 Trials studying Prostate Cancer
5,349 Patients Enrolled for Prostate Cancer
Alejandro SanchezPrincipal InvestigatorHuntsman Cancer Institute/ University of Utah
1 Previous Clinical Trials
153 Total Patients Enrolled

Eligibility Criteria

Age 18+ · Male Participants · 9 Total Inclusion Criteria

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Frequently Asked Questions

To what degree is Metastasectomy a risk-free procedure?

"Our team at Power has assigned Metastasectomy a safety score of 2 because Phase 2 trials have only provided evidence confirming its security, not necessarily its efficacy." - Anonymous Online Contributor

Unverified Answer

How many volunteers are engaged in the experiment?

"Indeed, the information available on clinicaltrials.gov attests to this trial's ongoing recruitment efforts. It was first posted in September 2019 and last updated in January 2022; currently searching for 40 participants at a single site." - Anonymous Online Contributor

Unverified Answer

Are there still available spots in this trial for participants?

"As per information available on clinicaltrials.gov, this medical trial is currently accepting participants. It was initially posted in September 2019 and the latest update was made in April 2022." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.