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Amino Acid

Dietary Supplement for Osteoarthritis

N/A
Waitlist Available
Led By Guangju Zhai, PhD
Research Sponsored by Memorial University of Newfoundland
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Must be ambulatory
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 20 months
Awards & highlights

Study Summary

This trial will test whether or not arginine can help with osteoarthritis by looking at cartilage health and participant symptoms.

Who is the study for?
This trial is for adults with primary knee osteoarthritis who are scheduled for knee replacement surgery within the next 6 months, can walk on their own, and live near St. John's in Canada. It excludes those with other types of arthritis or recent treatments/supplements that could affect results.Check my eligibility
What is being tested?
The study tests if taking arginine supplements affects osteoarthritis progression. Participants will be split into two groups: one taking arginine and the other not taking anything. Their joint health will be monitored through lab tests and questionnaires.See study design
What are the potential side effects?
While specific side effects aren't listed, dietary supplements like arginine may cause gastrointestinal discomfort, allergies, changes in blood pressure, or interact with certain medications.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I can walk on my own.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 20 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 20 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Target Gene Expressions in Osteoarthritic Knee Cartilage after 6 Months of Supplementation
Secondary outcome measures
Knee
SF-36 to Measure Changes in Physical and Mental Function between baseline and at 12 Months Post-surgery
SF-36 to Measure Changes in Physical and Mental Function between baseline and at 6 Months
+4 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: ArginineExperimental Treatment1 Intervention
L-arginine 1.5 g capsule by mouth, once daily for 6 months
Group II: No InterventionActive Control1 Intervention
no supplement for 6 months
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
L-arginine
2016
Completed Phase 4
~1380

Find a Location

Who is running the clinical trial?

Memorial University of NewfoundlandLead Sponsor
68 Previous Clinical Trials
1,831,984 Total Patients Enrolled
2 Trials studying Osteoarthritis
330 Patients Enrolled for Osteoarthritis
Ocean Frontier InstituteUNKNOWN
Guangju Zhai, PhDPrincipal InvestigatorMemorial University of Newfoundland

Media Library

L-arginine (Amino Acid) Clinical Trial Eligibility Overview. Trial Name: NCT03665116 — N/A
Osteoarthritis Research Study Groups: Arginine, No Intervention
Osteoarthritis Clinical Trial 2023: L-arginine Highlights & Side Effects. Trial Name: NCT03665116 — N/A
L-arginine (Amino Acid) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03665116 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any available opportunities for participants in this experiment?

"This clinical study, which was initially listed on March 5th 2019 is not presently searching for participants. However, a quick glance at clinicaltrials.gov reveals that 693 other studies are actively recruiting patients to participate in their trials as of April 4th 2022."

Answered by AI
Recent research and studies
Osteoarthritis and CartilageJournal
Projecting the Direct Cost Burden of Osteoarthritis in Canada Using a Microsimulation Model
Sharif, B., J. Kopec, N. Bansback, M.M. Rahman, W.M. Flanagan, H. Wong, P. Fines, and A. Anis. 2015. “Projecting the Direct Cost Burden of Osteoarthritis in Canada Using a Microsimulation Model”. Osteoarthritis and Cartilage. Elsevier BV. doi:10.1016/j.joca.2015.05.029.
Arthritis & RheumatismJournal
Do Antioxidant Micronutrients Protect Against the Development and Progression of Knee Osteoarthritis?
McAlindon, Timothy E., Paul Jacques, Yuqing Zhang, Marian T. Hannan, Piran Aliabadi, Barbara Weissman, David Rush, Daniel Levy, and David T. Felson. 1996. “Do Antioxidant Micronutrients Protect Against the Development and Progression of Knee Osteoarthritis?”. Arthritis & Rheumatism. Wiley. doi:10.1002/art.1780390417.
MethodsJournal
Analysis of Relative Gene Expression Data Using Real-time Quantitative PCR and the 2−ΔΔCT Method
Livak, Kenneth J., and Thomas D. Schmittgen. 2001. “Analysis of Relative Gene Expression Data Using Real-time Quantitative PCR and the 2−ΔΔCT Method”. Methods. Elsevier BV. doi:10.1006/meth.2001.1262.
Nutrition in Clinical PracticeJournal
High Prevalence of Suboptimal Vitamin D Status and Bone Loss in Adult Short Bowel Syndrome Even After Weaning Off Parenteral Nutrition
Fan, Shengxian, Xiaodong Ni, Jian Wang, Yongliang Zhang, Shen Tao, Wencheng Kong, Yousheng Li, and Jieshou Li. 2016. “High Prevalence of Suboptimal Vitamin D Status and Bone Loss in Adult Short Bowel Syndrome Even After Weaning Off Parenteral Nutrition”. Nutrition in Clinical Practice. Wiley. doi:10.1177/0884533616665784.
All > Oa
~6 spots leftby May 2025
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