Anti-inflammatory Diet for Crohn's Disease
(CD Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
Patients with inflammatory bowel disease (IBD) often have narrowed microbial diversity and altered composition and function of the gut microbiome. We anticipate the anti-inflammatory diet, when compared with the usual diet, to produce favorable changes in these multi-omics profiles. These findings will provide insight into the interactions between diet and host biology, while providing clues on the mechanisms of diet therapy's effect and CD pathogenesis.
Will I have to stop taking my current medications?
The trial requires that if you are currently taking immunosuppressants, immunomodulators, corticosteroids, or 5-aminosalicylates, you must keep the same doses during the study, except for corticosteroids, which can be tapered off. You must also stop using probiotics or dietary supplements for the length of the study.
Is the anti-inflammatory or Mediterranean diet safe for humans?
How is the anti-inflammatory diet treatment for Crohn's disease different from other treatments?
The anti-inflammatory diet, specifically the Mediterranean diet, is unique because it focuses on reducing inflammation through dietary changes, such as increasing antioxidants and modifying dietary fats, rather than using medication. This approach can improve disease activity and inflammatory markers in Crohn's disease patients by altering gut microbiota and reducing chronic inflammation.12346
What data supports the effectiveness of the treatment Anti-inflammatory diet for Crohn's Disease?
Research shows that the Mediterranean diet, which is part of the anti-inflammatory diet, can help reduce inflammation and improve symptoms in people with Crohn's disease. Studies have found that this diet improves clinical scores and inflammatory markers, suggesting it can be beneficial for managing the condition.12678
Who Is on the Research Team?
Zhaoping Li, MD, PhD
Principal Investigator
University of California, Los Angeles
Are You a Good Fit for This Trial?
This trial is for adults aged 18-75 with mild to moderate Crohn's Disease, confirmed by a previous biopsy. Participants should not have severe other conditions like heart or liver disease, recent hospitalizations, substance abuse issues, or be pregnant. They must be willing to stop taking probiotics and certain medications without changing their dosage during the study.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants are placed on an anti-inflammatory whole food diet for 8 weeks and assessed every 2 weeks for adherence
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Anti-inflammatory diet
- Regular diet
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, Los Angeles
Lead Sponsor