TEVAR + BMT for Aortic Dissection
(ACUTE-B Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of the study is to conduct a randomized controlled trial comparing best medical therapy (BMT) alone to BMT with thoracic endovascular aortic repair (BMT+TEVAR) for uncomplicated acute type B aortic dissection.
Will I have to stop taking my current medications?
The trial information does not specify if you need to stop taking your current medications. However, it mentions that participants should have their pain and blood pressure controlled with up to three intravenous antihypertensive medications, which suggests that some medication adjustments might be necessary.
Is TEVAR combined with BMT safe for treating aortic dissection?
Research shows that thoracic endovascular aortic repair (TEVAR) combined with best medical therapy (BMT) is generally safe for treating uncomplicated type B aortic dissection, with studies focusing on early and mid-term outcomes. While some reports show inconsistent results, TEVAR is commonly used and considered safe for this condition.12345
How is the TEVAR + BMT treatment different from other treatments for aortic dissection?
What data supports the effectiveness of the treatment TEVAR + BMT for Aortic Dissection?
Who Is on the Research Team?
Kristofer M Charlton-Ouw, MD, FACS
Principal Investigator
University of Texas Health Science Center, UT Medical School Department of Cardiothoracic and Vascular Surgery, Houston
Are You a Good Fit for This Trial?
This trial is for adults over 18 with a recent (≤30 days old) uncomplicated acute type B aortic dissection, who've been stabilized and can follow the study plan. It's not for those with complicated cases, other health trials soon, severe kidney issues, recent major health events like heart attacks or strokes, pregnant/breastfeeding women, or certain genetic disorders.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants are randomly allocated to either best medical therapy (BMT) alone or BMT with thoracic endovascular aortic repair (TEVAR)
Follow-up
Participants are monitored for safety, effectiveness, and quality of life changes after treatment
What Are the Treatments Tested in This Trial?
Interventions
- BMT
- BMT+TEVAR
BMT+TEVAR is already approved in European Union, United States, Canada for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
The University of Texas Health Science Center, Houston
Lead Sponsor