Reviewed by Michael Gill, B. Sc.
Image of National Institutes of Health Clinical Center in Bethesda, United States.
Phase-Based Progress Estimates

1/Focal SBRTfor Prostate Cancer

Background: The current standard treatment of prostate cancer is either surgery or radiation. Typically, this includes either the removal or radiation of the whole prostate gland. Many people now seek out focal therapy options to decrease the side effects of treatment. Until now, several forms of physical destruction with heat (thermal ablation), cold (cryotherapy), sound waves (HIFU), laser (FLA), and electrical energy (IRE). A new type of radiation (SBRT) may be an effective way to cure men of early-stage prostate cancer with fewer side effects than standard treatments. Objective: To see how people with untreated localized prostate cancer will respond to focal therapy with SBRT. Eligibility: People aged 18 years and older with untreated localized prostate cancer (prostate cancer which has not spread outside of the prostate gland). Design: Participants will undergo screening including blood tests, an MRI, a PSMA PET/CT (18F-DCFPyL), and a biopsy. Small, non-radioactive, gold seeds about the size of a grain of rice will be placed in and/or around the tumor to help target the radiation treatment. Radiation (SBRT) will occur in 2 separate sessions about 1 week apart. No sedation is used, these sessions are painless. Each session will take about 1-2 hours. Participants can go home afterwards. Follow-up will continue for 2 years with repeat scans (MRI and PSMA PET/CT) and blood (PSA) tests. After two years, a biopsy will be done to understand the impact of this new treatment on prostate cancer.
Phase 2
Waitlist Available
National Institutes of Health Clinical CenterKrishnan R Patel, M.D.
25 Prostate Cancer Clinical Trials Near Me
Top Hospitals for Prostate Cancer Clinical Trials
Image of Carolina Urologic Research Center in South Carolina.
Carolina Urologic Research Center
Myrtle Beach
9Active Trials
73All Time Trials for Prostate Cancer
2003First Prostate Cancer Trial
Top Cities for Prostate Cancer Clinical Trials
Image of New York in New York.
New York
60Active Trials
Memorial Sloan Kettering Cancer CenterTop Active Site
Image of Los Angeles in California.
Los Angeles
56Active Trials
USC / Norris Comprehensive Cancer CenterTop Active Site
Prostate Cancer Clinical Trials by Phase of Trial
Phase < 1 Prostate Cancer Clinical Trials
6Active Prostate Cancer Clinical Trials
6Number of Unique Treatments
3Number of Active Locations
(68Ga)PSMA-HBED-CCGallium-68 citrate PETAdaptive Androgen Deprivation Therapy (ADT)Positron emission tomography (PET)/magnetic resonance imaging (MRI)Metformin and Lifestyle Modification ArmMagnetic Resonance Spectroscopic Imaging