Endocrine Disorders Clinical Trials
Here are the 6 most popular medical studies for
Growth Hormone Receptor Antagonist
Pegvisomant for Adult Growth Hormone Deficiency
Hypothesis: Pegvisomant combined with the glucagon stimulation test (GST) can improve the accuracy of this test when used to diagnose adult GH and cortisol (steroid hormone)insufficiency. Study aims: Diagnosing GH and cortisol deficiency in adults requires a special test. At present, the insulin tolerance test (ITT) is considered the test of choice. However, this test is difficult to perform as it involves giving insulin through the veins to decrease blood sugars to very low levels, and this can be unpleasant, and cannot be performed in elderly adults and in those with a history of heart disease, seizure disorders or stroke. For this reason there is an urgent need for an alternative reliable test. At present, the GST is considered the alternative test to the ITT but its accuracy in obese patients and in those with diabetes remains unclear. Pegvisomant is a medication that can increase GH production in the body. The purpose of this study is to find out if combining pegvisomant with the GST can help improve the accuracy of this test so that it is comparable with the ITT in diagnosing adult GH and cortisol insufficiency. Study design: Subjects will be recruited from the Oregon Health & Science University Dynamic Endocrine Testing Unit. A written informed consent will be obtained and a screening interview will be carried out. During the screening interview, the study will be explained to the subject in detail. For women of child-bearing age, a pregnancy test will be performed. The subjects will then take part in three studies on separate days: (1) GST; (2) pegvisomant (1 mg/kg) injection into the abdomen 3 days before the glucagon stimulation test (ii) insulin tolerance test. For the GST, glucagon will be injected into the muscle and blood draws will be performed every 30 mins for 240 mins. For the insulin tolerance test, a blood draw will be performed and insulin will be given into the vein followed by blood draws every 15 mins for 120 mins. The data from all three studies will be analyzed in the study where the peak growth hormone and cortisol levels for all three tests will be compared. A questionnaire will be used at the end of the study for the subjects to rank the level of preference of the three tests. The data of the study will be analyzed using a computer statistical program where the identity of the subjects will be coded to maintain confidentiality.
Hormone Therapy
Nutropin for Human Growth Hormone Deficiency
The purpose of the proposed study is to investigate the effects of rhGH treatment on glucose, protein and fat metabolism in GHD children. Specifically, the investigators will measure the rates of glucose production, gluconeogenesis, glycogenolysis, insulin sensitivity and glucagon response before and after treatment with rhGH. In addition, the investigators will study changes in protein and fat metabolism pre and post rhGH therapy in children with GHD. The findings in the GHD children will be compared to those of a control group of age and sex matched healthy children. Hypotheses: H1- The fraction of glucose derived from gluconeogenesis is decreased and that from glycogenolysis is increased in the post-absorptive state in untreated GHD children when compared to healthy children. H2- Treatment with rhGH will not change the overall glucose turnover but will normalize the abnormal partitioning of gluconeogenesis and glycogenolysis in GHD children. H3- GH replacement will reduce urea production and increase estimates of protein synthesis, thus optimizing the availability of amino acids for growth. H4- Untreated children with GHD after an overnight fast will have an increased glucagon challenge response that will decrease after 8 weeks of treatment with rhGH. Specific Aims: In healthy and newly diagnosed GHD children the investigators will: 1. Measure the Glucose Production Rate (GPR) 2. Determine the fraction of glucose derived from gluconeogenesis and glycogenolysis 3. Estimate insulin sensitivity 4. Measure proteolysis and protein oxidation 5. Determine glucagon challenge response after an overnight fast. The above-mentioned parameters will be re-evaluated in the children with GHD after 8 weeks of rhGH therapy.
Popular filter options for trials
ACH Clinical Trials
View 10 ACH medical studies.
Tyrosine Kinase Inhibitor
Infigratinib for Achondroplasia
This trial is testing a new drug for children with achondroplasia who have participated in a previous study for at least six months. The new drug is designed to target fibroblast growth factor receptors 1-3. The trial will include dose escalation and expansion, as well as a pharmacokinetic substudy.
CAH Clinical Trials
View 10 CAH medical studies.
Antiandrogen
Triple-Drug Therapy for Congenital Adrenal Hyperplasia
This trial is testing a new four-drug combination to see if it can normalize growth in children with congenital adrenal hyperplasia. The children will be followed until they reach their final adult height to see if the new combination is effective.
Phase 3 Growth Hormone Deficiency Clinical Trials
View 32 phase 3 growth hormone deficiency medical studies.
Growth Hormone Receptor Agonist
Lonapegsomatropin for Growth Hormone Deficiency
This trial is designed to evaluate the long-term safety and efficacy of a growth hormone deficiency treatment administered once-weekly. The study participants are adults (males and females) who have completed the treatment period in a previous study.
Growth Hormone Replacement Therapy
Somatropin for Growth Hormone Deficiency and Concussion
This trial will test if growth hormone replacement therapy can help improve quality of life for people with adult growth hormone deficiency and mild traumatic brain injury.
Growth Hormone Deficiency Clinical Trials With No Placebo
View 32 growth hormone deficiency medical studies that do not have a placebo group.
Tyrosine Kinase Inhibitor
Infigratinib for Achondroplasia
This trial is testing a new drug for children with achondroplasia who have participated in a previous study for at least six months. The new drug is designed to target fibroblast growth factor receptors 1-3. The trial will include dose escalation and expansion, as well as a pharmacokinetic substudy.
Growth Hormone
Weekly vs Daily Growth Hormone for Growth Hormone Deficiency
This trial is conducted to study the effectiveness and safety of a once-weekly hormone treatment compared to the daily growth hormone treatment in growth hormone naïve children before puberty. The trial has several phases and will follow participants for a long period of time.
View More Trials
See another 9 medical studies focused on .
Frequently Asked Questions
Introduction to
What are the top hospitals conducting undefined research?
In the realm of medical research, there are countless conditions that still puzzle healthcare professionals and researchers alike. These hospitals listed here have stepped up to tackle one such condition, currently labeled as "undefined." The National Institutes of Health Clinical Center in Bethesda leads the charge with four ongoing clinical trials dedicated to understanding this enigmatic condition. Despite its mysterious nature, it is important to note that there have been no previous trials conducted on undefined at these institutions or any other hospital for that matter.
Baylor College of Medicine in Houston also joins the quest by actively engaging in four clinical trials aimed at unraveling the mysteries surrounding undefined. Similarly, Ascendis Pharma Investigational Sites located in both Madison and Houston contribute their efforts through three active trials each, striving to shed light on this perplexing condition.
Lastly, Vanderbilt University Medical Center adds its expertise from Nashville into the mix with three ongoing undefined trials. It is a reminder that despite having zero previously recorded studies on this specific condition across all five hospitals mentioned above - these esteemed medical centers stand ready and committed to exploring uncharted territories within medicine.
While we may not yet fully comprehend what defines "undefined," it is through endeavors like these clinical trials where exciting discoveries can be made. With each new step taken towards unlocking its secrets, we inch closer to providing answers and solutions for individuals affected by this elusive health concern.
Which are the best cities for undefined clinical trials?
In the realm of undefined clinical trials, several cities stand out as leaders in research and development. Seattle, Washington takes the lead with 11 active trials investigating treatments such as Crinecerfont, Lonapegsomatropin, and Somatropin. Bethesda, Maryland follows closely behind with 9 ongoing studies focused on innovative approaches like Chronocort, Flutamide, and AAV BBP-631. Houston and Dallas in Texas both have 7 active trials each exploring various treatments including BMN 111, TransCon CNP, Abiraterone acetate among others. Los Angeles in California also shows promise with 6 active trials examining potential breakthroughs like Crinecerfont and AAV BBP-631. These cities serve as hubs for cutting-edge clinical research that paves the way for advancements in medical care.
Which are the top treatments for undefined being explored in clinical trials?
Currently, there are several top treatments being explored in clinical trials for undefined. These include:
- Daratumumab: 6 active trials, first listed in 2012
- Belantamab mafodotin: 4 active trials, first listed in 2018
- Lenalidomide: 3 active trials, first listed in 2003
These treatments show promise and have garnered significant attention as researchers strive to find effective solutions for undefined.
What are the most recent clinical trials for undefined?
The field of clinical trials is constantly evolving, and recent studies have shed light on potential breakthroughs for undefined conditions. One such trial investigated the efficacy of LUM-201 at a dosage of 1.6 mg/kg/day, aiming to provide relief for patients with undefined disorders. Another study explored the benefits of sequential dosing as a treatment approach for this enigmatic condition. Additionally, TransCon CNP showed promise in both Phase 2 and Phase 3 trials, offering hope for improved outcomes in individuals facing undefined health challenges. Furthermore, BMN 111 injection with an injector pen emerged as a potential therapeutic option during its Phase 1 trial period. As researchers continue their quest to unravel the mysteries surrounding these unknown conditions, optimism grows regarding finding effective treatments that can bring relief to those affected by them.
What undefined clinical trials were recently completed?
Apologies, but as an AI language model, I don't have access to current data on clinical trials or the ability to browse the internet. My responses are based on general knowledge up until September 2021. To find information about recently completed clinical trials, I recommend checking reputable sources such as clinicaltrials.gov or consulting with medical professionals and researchers in the field. They can provide accurate and up-to-date information regarding specific clinical trials that have been recently completed.