Essential Tremor Clinical Trials 2022

Essential Tremor studies recruiting patients for novel treatments. Filter by phase, distance, and inclusion criteria to find your perfect essential tremor clinical trial in 2022.

Condition

Location

Distance

Age

Clinical Trials Essential Tremor Clinical Trials 2022

Phase-Based Estimates

10 Mg PRAX-114 Or 20 Mg PRAX-114for Familial Tremor

Farmington Hills, MI

Locally Advanced

Farmington Hills, MI

This is a 2-part clinical trial to evaluate the safety, tolerability, pharmacokinetics, and efficacy of PRAX-114 in participants with essential tremor (ET). Part A is a randomized, double-blind, placebo-controlled, three-period, three-sequence, crossover design where participants will receive a single dose of 10 mg PRAX-114, 20 mg PRAX-114, and matching placebo. Part B is an open-label design where participants from Part A, after washout and confirmation of eligibility may elect to participate in Part B where all participants will receive 10 mg once every morning (QAM) for the first 14 days. Based on investigator judgement of the safety and tolerability, the dose for Days 15 to 28 could be increased to 20 mg QAM.

Phase-Based Estimates

DystoniaNet-based Diagnosis Of Isolated Dystoniafor Parkinson Disease

Waitlist Available

This research involves retrospective and prospective studies for clinical validation of a DystoniaNet deep learning platform for the diagnosis of isolated dystonia.

Phase-Based Estimates

Functional Electrical Stimulation (FES)for Tremor

Individuals experiencing tremors face difficulty performing activities of daily living caused by involuntary oscillation of the muscles in the hands and arms. Current solutions to help suppress tremors include medication, surgery, assistive devices and lifestyle change. However, each of these has a drawback of its own including cost and unwanted side effects. Aside from the solutions listed, it has been shown that functional electrical stimulation(FES) is a possible solution to help suppress tremor. Additionally, FES can be combined with different technologies including accelerometers, gyroscopes and motion capture to develop a closed loop system for tremor suppression. However, this has drawbacks including signal interference and the need for multiple sensor to fully classify the tremor. Ultrasound imaging solves some of these issues because it can provide a direct visualization of hand muscles that contribute to tremor. This study will focus on detecting characterizing and differentiating tremors from voluntary hand motion using ultrasound imaging. The results obtained from this study will help design FES-based tremor-suppression techniques in the future. This study will target both subjects with different tremor disorders and able bodied subjects.

Phase-Based Estimates

SAGE-324for Familial Tremor

The primary purpose of this study is to evaluate the dose-response relationship of different doses of SAGE-324 on upper extremity tremor in participants with essential tremors (ET).

Phase-Based Estimates

Skin Surface Vibrationfor Focal Dystonia

Gainesville, FL

Gainesville, FL

This study is evaluating whether vibration applied to the skin might improve motor control in people with movement disorders.

Phase-Based Estimates

120 Mg PRAX-944for Tremor

Gainesville, FL

Locally Advanced

Gainesville, FL

This study is evaluating whether a drug called PRAX-944 might be effective in treating essential tremor.

Phase-Based Estimates

Deep Brain Stimulationfor Familial Tremor

This study is evaluating whether a specific type of brain stimulation may help improve memory.

Phase-Based Estimates

Gamma Knife VIM Thalamotomyfor Familial Tremor

Sherbrooke, Canada

Sherbrooke, Canada

This study is evaluating whether a surgery to remove a part of the brain called the thalamus can improve symptoms of essential tremor.

Phase-Based Estimates

MRgFUS Thalamotomyfor Tremor

Toronto, Canada

Toronto, Canada

This study is evaluating whether a second MR-guided focused ultrasound thalamotomy can be performed safely and effectively in patients with medication-refractory essential tremor.

Phase-Based Estimates

Magnetic Resonance-guided Focused Ultrasound VIM Thalamotomyfor Familial Tremor

Toronto, Canada

Toronto, Canada

This study is evaluating whether a surgery to treat essential tremor can be done on the other side of the brain.

Phase-Based Estimates

Peripheral Electrical Stimulationfor Familial Tremor

This study is evaluating whether peripheral electrical stimulation may help reduce tremors in individuals with Parkinson's disease or essential tremor.

Phase-Based Estimates

Electrophysiological Data Collectionfor Parkinson Disease

In this research study the researchers want to learn more about brain activity related to speech perception and production.

Phase-Based Estimates

DBS Electrode Implantation Using D1 Sterotactic Systemfor Familial Tremor

Waitlist Available

This study is evaluating whether a new type of brain surgery can help treat individuals with neurological disorders.

Phase-Based Estimates

Exablate Model 4000 Type 1.0/1.1for Tremor

Charlottesville, VA

Waitlist Available

Charlottesville, VA

This study is evaluating whether a surgery which uses sound waves to destroy brain tissue may help reduce tremors.

Phase-Based Estimates

Vim-Deep Brain Stimulationfor Familial Tremor

Minneapolis, MN

Locally Advanced

Minneapolis, MN

This study is evaluating whether computational models can help guide clinicians in the selection of optimal settings for deep brain stimulation.

Phase-Based Estimates

Active Biphasic Pulse Stimulation---VIN Biphasicfor Familial Tremor

Gainesville, FL

Gainesville, FL

This study is evaluating whether a change in the way brain stimulation is delivered may help Essential Tremor patients.

Phase-Based Estimates

Cala TWO Stimulatorfor Familial Tremor

Locally Advanced

Essential tremor (ET) is the most common movement disorder in the United States and affects up to 5% of the population. ET patients experience involuntary shaking of the hands, head and/or voice that can range from mildly limiting to severely disabling. Treatment options are limited and there are currently no medications specifically designed to treat it, and medications that are prescribed to relieve tremors are often limited by either inadequate efficacy or intolerable side effects. A subset of essential tremor patients whose tremors are inadequately treated by medication choose to undergo deep brain stimulation (DBS) of the ventral intermediate thalamic nucleus. DBS has been shown to be highly effective for tremor suppression. However, DBS carries significant risks. As a result, a very small (less than 3%) percentage of essential tremor patients undergo DBS therapy. The medical technology company Cala Health has developed a wristband device (the Cala TWO) that offers individuals with essential tremor a novel non-pharmacological, non-invasive alternative, in the form of stimulation of peripheral nerves, to aid in hand tremor relief. This innovative form of therapy has the potential to have important health, quality of life, and economic benefits for essential tremor patients. The present pilot study (Aim 1) will assess the effectiveness of 3-month twice daily treatment with the Cala TWO device to aid in the relief of hand tremors in adult essential tremor subjects that have been approved to undergo deep brain stimulation surgery at Mayo Clinic - Rochester. This study is a prospective, within subject, non-significant risk study at Mayo Clinic - Rochester, enrolling approximately 20 subjects. A completely optional component of this study (Aim 2) is seeking to perform three standard PET/CT sessions on a subset of these subjects (n=10) at Mayo Clinic - Rochester to evaluate changes in brain metabolic activity as a result of 3 months treatment with the device. The first session would take place upon a subjects entry into the study (start of month 1) and prior to any treatment with the Cala device, a second the following day after a 40 minute treatment period with the Cala device, and a third session at the end of the third month. This study is a prospective, within subject, greater than minimum risk study.

Phase-Based Estimates

Unframed Virtual Conefor Familial Tremor

This study is evaluating whether a new type of surgery may help reduce tremors for individuals who are not candidates for deep brain stimulation.

Phase-Based Estimates

Therapeutic Stimulation Patternsfor Familial Tremor

Gainesville, FL

Waitlist Available

Gainesville, FL

This study is evaluating whether non-regular patterns of deep brain stimulation can improve symptoms in people with Parkinson's disease, essential tremor, or multiple sclerosis.

Phase-Based Estimates

Transcranial ExAblatefor Tremor

Waitlist Available

This study is evaluating whether a new device can help people with essential tremor.

Phase-Based Estimates

Transcranial ExAblatefor Tremor

Waitlist Available

This study is evaluating whether a device can help reduce tremor in people with essential tremor.

Phase-Based Estimates

ES-481for Tremor, Essential

This Pilot Phase 2A study will investigate the safety, tolerability, and pharmacokinetics (PK) of ES-481 in adult patients with essential tremor.

Phase-Based Estimates

BOTOXfor Tremor

Crab Orchard, WV

Crab Orchard, WV

Upper limb essential tremor (UL ET) is a movement disorder characterized by postural and/or kinetic tremor. It can cause difficulty with everyday tasks such as writing, pouring, and eating, and patients also experience associated social embarrassment. This study will assess how safe and effective BOTOX is in treating UL ET. Adverse events and change in disease activity will be evaluated. BOTOX is an investigational drug being developed for the treatment of UL ET. Participants are randomly assigned to 1 of the 4 groups, called treatment arms. Each group receives different treatment. There is 1 in 2 chance that participants will be assigned to placebo. Around 174 participants, aged 18 to 80 years with UL ET will be enrolled in approximately 35 sites in North America. Participants will receive BOTOX or placebo injections in Cycle 1 and Cycle 2. In Cycle 3, participants will receive unilateral or bilateral BOTOX injections. Each cycle is 12 weeks. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.

Phase-Based Estimates

JZP385for Familial Tremor

This study is evaluating whether a drug called JZP385 can help people with ET.

Phase-Based Estimates

VIM Stimulationfor Tremor

Locally Advanced

Deep brain stimulation (DBS) of the ventral intermediate nucleus of the thalamus (VIM) is an FDA approved treatment for medication refractory essential tremor (ET). However, VIM stimulation can be associated with impacts on speech and balance. There is also suggestion that there may be habituation to stimulation in more than half of these patients. Stimulation of the posterior subthalamic area (PSA) has been found to be beneficial in tremor control as well. In fact, there is thought that the improvement in tremor in standard VIM DBS stimulation may be related to stimulation effects on the PSA. Updates in DBS stimulation allow to stimulate more than one area of the brain independently, while using a single lead. In this study, we will recruit patient who are referred for VIM DBS to a randomized cross-over trial in which they will receive VIM, PSA, or dual stimulation. We will assess tremor qualitatively and quantitatively, in addition to evaluating side effects, including quantitative gait analysis on each setting. The pre-operative, operative, and initial programming evaluation will be performed per standard of care. After baseline assessment and initial programming, subjects will be evaluated in a blinded manner after they have been on each setting for 2 weeks. The entire duration of the study from baseline visit through final study visit will be 17 weeks. For subjects who are clinically evaluated in our outpatient clinics, we will review their charts at 6 months for stimulation parameters and clinical information as it relates to their tremor.

Phase-Based Estimates

NT 201for Familial Tremor

The purpose of this study is to determine whether a single treatment with administration of NT 201 (botulinum toxin) is superior to placebo (no medicine) for one-sided treatment of essential tremor in the arm (Unilateral Period). Participants will be assigned to the treatment groups by chance and neither the participants nor the research staff who interact with them will know the allocation. The following treatment cycle will investigate the safety and tolerability of two-sided treatment with NT 201 (botulinum toxin) (Open Label Bliaterial Period). All participants will receive NT 201 treatment.

Phase-Based Estimates

Perampanelfor Familial Tremor

Los Angeles, CA

Waitlist Available

Los Angeles, CA

Obtain information on whether the medication Perampanel reduces tremor in people with essential tremor and is well-tolerated.

Phase-Based Estimates

Deep Brain Stimulationfor Familial Tremor

Gainesville, FL

Gainesville, FL

This study is evaluating whether a new type of deep brain stimulation may help reduce tremors for individuals with essential tremor.

Phase-Based Estimates

Gamma Knife Radiosurgeryfor Familial Tremor

Waitlist Available

This study is evaluating whether gamma knife radiosurgery is effective for essential tremor.

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