Browse 31 Essential Tremor Medical Studies Across 100 Cities
1 Phase 3 Trial · 184 Essential Tremor Clinics
What Are Essential Tremor Clinical Trials?
Essential tremor is a neurological movement disorder that causes your head, trunk, hands, legs, or voice to shake rhythmically. It is often confused with Parkinson's disease, but key differences exist. For instance, in ET, the tremors are worse when the affected body part is in use; in contrast, in Parkinson’s disease, the tremors are worse when the affected body part is at rest.
In advanced stages, the condition can disrupt and prevent patients from completing basic tasks, such as eating, drinking, and dressing.
Many essential tremor clinical trials focus on diagnosing and managing essential tremors through drugs and stimulations.
Why Is Essential Tremor Being Studied Through Clinical Trials?
Essential tremor is the most common movement disorder and has an estimated global prevalence of up to 5% of the population. Family history can be found in nearly 50% of cases and in 90% concordance in monozygotic twins.
There is no identified cause of essential tremors, and the condition is not usually dangerous but can get frustrating for patients.
What Are The Types of Treatments Available For Essential Tremor?
There are multiple treatments available for essential tremors. Less impaired patients may choose to skip treatment altogether. Some patients with significant functional impairment get treatment and can choose from non-medical, medical, or interventional therapy.
Non-medical treatment options include weighing the wrist or affected body part, avoiding dietary stimulants, non-medical relaxation techniques, and biofeedback. Tremor medications should be minimized or eliminated due to adverse side effects.
Medical therapy includes essential tremor clinical trials that are placebo-controlled or FDA- approved, meet the class I evidence criteria, and are classified into first-line, second-line, and third-line treatments.
What Are Some Recent Breakthrough Clinical Trials For Essential Tremor?
There have been several landmark studies involving essential tremors in recent years. Some of the most notable studies are:
2019: Diagnosis And Management - this study discusses the emerging treatments but supports the efficiency of first-line treatments (propranolol and primidone) identified decades ago. Moreover, current research explores novel oral treatments, chemodenervation, and noninvasive neuromodulation to treat essential tremors.
2020: Neuropharmacological Options - this study concludes that beta-blocker propranolol and the antiepileptic drug primidone are the drugs that have shown higher efficacy in the treatment of ET. Other drugs tested in ET patients have shown different degrees of efficacy or have not been useful. Moreover, botulinum toxin A injections could be useful in treating some patients with ET refractory to pharmacotherapy.
Who Are Some Of The Key Opinion Leaders / Researchers / Institutions Conducting Essential Tremor Clinical Trial Research?
Dr. Vibhor Krishna, MD
Dr. Vibhor Krishna is a board-certified neurosurgeon with expertise in functional neurosurgery and neuromodulation. He was recently awarded the R01 grant from the National Institutes of Health to fund his focused ultrasound ablation research for essential tremor patients.
The University of Arkansas for Medical Sciences (UAMS)
UAMS participated in the largest therapeutic trial ever conducted in essential tremors, called the PROspective study for SymPtomatic relief of Essential tremors with Cala Therapy (PROSPECT).