This trial is evaluating whether 120 mg PRAX-944 will improve 2 primary outcomes, 19 secondary outcomes, and 1 other outcome in patients with Familial Tremor. Measurement will happen over the course of Up to 42 days.
This trial requires 131 total participants across 8 different treatment groups
This trial involves 8 different treatments. 120 Mg PRAX-944 is the primary treatment being studied. Participants will be divided into 6 treatment groups. Some patients will receive a placebo treatment. The treatments being tested are in Phase 2 and have already been tested with other people.
"The most consistent risk factor for disability is advancing age, especially for women. In men, the most consistent risk factor continues to be HTN, though it is unclear why this risk is greatest for individuals with pre-HTN disease and/or HTN." - Anonymous Online Contributor
"Findings from a recent study suggest that the genetics for tremor in FHT families are probably complex and there may be additional loci that modulate the risk for tremor in affected members with FHT." - Anonymous Online Contributor
"Prax-944 120 mg appears to be as efficacious as 120 and 280 mg of mexiletine for tremor reduction. When comparing this dose with 240 mg of mexiletine, a similar reduction in tremor amplitude was seen on the posttreatment session with 120 mg of prax-944, but this was not as statistically significant as with the 280 or 240 mg of mexiletine dose. Side effects were mild, and no serious side effects of this drug were reported." - Anonymous Online Contributor
"There is a high remission rate in familial tremor (93%), even in families with a positive family pedigree with epilepsy. F-T can be considered an alternative to pharmacological treatment of tremor." - Anonymous Online Contributor
"Data from a recent study presents a clear trend in the decline in the diagnosis of FT. The rate of decline observed in the USA and GB has been slower than that reported anywhere in the world. Possible reasons for this, such as greater awareness of FT and increased availability of clinical tests, warrant further studies to be undertaken." - Anonymous Online Contributor
"The treatment of choice for patients with familial tremor varies depending on the family history, the patient’s age, and the condition of the patient. In general, most treatments can be used to reduce the severity of the tremor. Physicians often recommend using a combination of different treatment options for the treatment of familial tremor." - Anonymous Online Contributor
"For diagnosis of familial tremor a combination of history of the disease and examination is necessary as there are few general signs of this condition. There is no evidence in the literature that shows what the genetic causes are for familial tremor. It is not known if there is a combination of symptoms and signs that occur with two or more other diseases or psychiatric conditions and those with family tremor may also be at higher risk for other CNS systemic diseases. It could be due to either a genetic or a metabolic condition." - Anonymous Online Contributor
"Familial tremor affects an estimated 5-16% of the population. Genetic and familial factors contribute to the risk of developing this disease. As the name suggests, the tremors of familial tremor are present in at least one family member. In contrast to most trembling families, trembling is not present in the other family members. If a family member has trembling with normal family history, it is likely that family members' genes are involved. The tremor is not tremulous in nature, and the tremors are not excessive. Most cases of familial tremor appear to be of idiopathic origin. Although the tremors are similar to the trembling seen in Parkinson's disease, it is not a disease of the peripheral nervous system." - Anonymous Online Contributor
"1. Genetic linkage could be shown between the tremor gene and loci at chromosomes 1, 2, 20, 22, and 7.\n2. It is likely to have a genetic component.\n3. In a recent study, findings in our family of familial tremor may in part be a result of hereditary [cerebral palsy](https://www.withpower.com/clinical-trials/cerebral-palsy).\n4. Genetic counseling of members of the family is suggested. This familial tremor may be part of a spectrum of disorders that includes Parkinson's disease and Pick's disease. They may also constitute a part of the familial tremor syndrome.\n5." - Anonymous Online Contributor
"Prax-944 in combination with carbamazepine (12.5 mg b.i.d.), primidone (10 mg o.d.), levetiracetam (100 mg b.d.), isoprenaline (400 mcg per day b.v.s.max. 1) is efficacious for both lowering and preventing the occurrence of tremor episodes. The efficacy in lowering tremor was observed at 1 and 5 weeks. The addition of valproate (50 mg b.i.d.) is associated with a significant worsening of tremor. [Power](https://www.withpower." - Anonymous Online Contributor
"Although we are still left with no firm evidence that any gene or gene-locus has been identified, we are in the process of doing genetic research. Since it may not be impossible for some genes to be identified, then by identifying and studying individuals with familial tremor in a familial tremor family, and collecting data from their family members and relatives, the gene(s) implicated in the specific subtypes of familial tremor could be discovered. If we are fortunate enough, then by studying the genes which encode the disease proteins, we will be in the position to develop therapies to treat the disorder. Since familial tremor has been found to be very common, it seems likely that it could be more common than many people would suspect." - Anonymous Online Contributor
"Prax-944 120 mg once daily is effective for treating the symptoms of FTM. Clinical improvement was noted in both treated and placebo groups, but a significant difference was shown only for patients in the treatment group who reported a good reduction in their tremor. Prax-944 can be considered as a reasonable therapy for many patients with FTM." - Anonymous Online Contributor