Cannabigerol for Psychological and Physiological Effects

(CBG Trial)

Overseen By Carrie Cuttler Dr. Cuttler, Ph.D., Psychology

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Washington State University

Disqualifiers: Psychiatric disorders, Neurological disorders, Diabetes, others

Compensation: Varies

Number of Visits: 5

100 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores how cannabigerol (CBG) affects mental and physical health, including mood, anxiety, stress, heart rate, and pain tolerance. Researchers aim to understand the potential benefits and side effects of CBG, such as sleepiness or increased appetite. Participants will receive either CBG or a placebo to compare results. English-speaking adults without serious psychiatric or neurological conditions, and who are not pregnant or breastfeeding, may find this trial suitable. As an unphased trial, it offers a unique opportunity to contribute to the foundational understanding of CBG's effects on health.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Is there any evidence suggesting that cannabigerol (CBG) is likely to be safe for humans?

Research has shown that cannabigerol (CBG) might help reduce stress and anxiety. In studies, participants who took CBG did not feel drugged or impaired, suggesting it might be easy to tolerate. However, more information is needed about its safety and possible side effects when taken orally. Some side effects under investigation include sleepiness, dry mouth, increased hunger, and dizziness. While CBG appears promising, further research is necessary to fully understand its safety for individuals. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Cannabigerol (CBG) is unique because it is a cannabinoid that may offer psychological and physiological benefits without the psychoactive effects often associated with THC, a well-known compound in cannabis. Unlike traditional treatments for mental health and stress-related conditions, which often include antidepressants or anti-anxiety medications, CBG may interact with the body's endocannabinoid system in a way that provides relief with potentially fewer side effects. Researchers are excited about CBG because it represents a natural alternative that could complement or even enhance existing therapies, offering a new pathway for those who may not respond well to conventional medications.

What evidence suggests that cannabigerol (CBG) might be an effective treatment for psychological and physiological effects?

This trial will compare the effects of Cannabigerol (CBG) with a placebo. Research has shown that CBG might help reduce anxiety and stress. In one study, participants who took 20 mg of CBG felt less anxious than those who took a placebo, which contained no active ingredients. Another survey found that many CBG users reported it helped with depression. Additionally, studies on thinking skills suggest CBG might improve memory and learning. Evidence also indicates that CBG might reduce inflammation in the brain, which could be promising for conditions like Alzheimer's and Parkinson's. While more research is needed, these early findings are encouraging for CBG's potential benefits. ^{1 2 3 6 7}

Are You a Good Fit for This Trial?

This trial is for individuals interested in participating in a study to assess the effects of cannabigerol (CBG), a compound found in cannabis. There are no specific conditions listed, so participants may be from the general population.

Inclusion Criteria

Fluent in English

I am over 21 years old.

Exclusion Criteria

Illiterate

Pregnant or breastfeeding

I have a history of low blood pressure.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

1 visit (virtual)

Baseline Assessment and CBG/Placebo Administration

Participants undergo baseline assessments and are administered either CBG or placebo

2.5 hours

2 visits (in-person)

Testing Session 1

Participants complete various psychological and physiological assessments after CBG/placebo administration

2.5 hours

1 visit (in-person)

Washout Period

Participants undergo a one-week washout period before the second testing session

1 week

Testing Session 2

Participants complete a second round of assessments with the opposite product (CBG or placebo)

2.5 hours

1 visit (in-person)

Follow-up

Participants are monitored for any delayed effects or side effects post-study

1-2 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Cannabigerol (CBG)

Trial Overview The study is testing how CBG affects psychological aspects like anxiety, mood, and memory, as well as physiological responses such as blood pressure and heart rate. Participants will receive either CBG or a placebo to compare outcomes.

How Is the Trial Designed?

Group I: CBG Arm Experimental Treatment 1 Intervention

Participants in this arm will receive CBG

Group II: Placebo Arm Placebo Group 1 Intervention

Participants in this arm will receive a placebo

Who Is Running the Clinical Trial?

Washington State University

Lead Sponsor

Trials

114

Recruited

58,800+

Published Research Related to This Trial

A survey of 127 CBG-predominant cannabis users revealed that most use it for medical purposes, particularly for treating anxiety, chronic pain, depression, and insomnia, with many reporting significant improvements in their conditions.

The study found a favorable safety profile for CBG, with 44% of users reporting no adverse effects and only a small percentage experiencing mild symptoms, suggesting that CBG-predominant cannabis may be a viable alternative to conventional medications.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Survey of Patients Employing Cannabigerol-Predominant Cannabis Preparations: Perceived Medical Effects, Adverse Events, and Withdrawal Symptoms. Russo, EB., Cuttler, C., Cooper, ZD., et al.[2023]

Cannabigerol (CBG) is a non-psychoactive cannabinoid that shows promise for various therapeutic applications, including reducing intraocular pressure and exhibiting anti-inflammatory and anti-tumoral effects, based on pre-clinical studies.

CBG acts as a partial agonist at cannabinoid receptors and interacts with other receptors, suggesting it could be a valuable component in developing treatments for conditions like anxiety and neuroprotection.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Pharmacological Aspects and Biological Effects of Cannabigerol and Its Synthetic Derivatives. Calapai, F., Cardia, L., Esposito, E., et al.[2022]

Cannabigerol (CBG) effectively reduces mechanical hypersensitivity in mice with cisplatin-induced peripheral neuropathy, suggesting its potential as a treatment for neuropathic pain.

The anti-nociceptive effects of CBG are mediated through specific receptors, as its efficacy was blocked by α2-adrenergic and CB1/CB2 receptor antagonists, but not by TRPV1 antagonists, indicating a targeted mechanism of action.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Cannabigerol (CBG) attenuates mechanical hypersensitivity elicited by chemotherapy-induced peripheral neuropathy. Sepulveda, DE., Morris, DP., Raup-Konsavage, WM., et al.[2022]

Cannabigerol (CBG) shows potential therapeutic benefits for neurological disorders and inflammatory bowel disease, with unique interactions at cannabinoid receptors and other receptors like α-2 adrenoceptors and 5-HT1A.

Despite its promising effects, CBG is largely unregulated and under-researched compared to other cannabinoids like CBD, highlighting the need for further studies to understand its safety and efficacy.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

The Pharmacological Case for Cannabigerol. Nachnani, R., Raup-Konsavage, WM., Vrana, KE.[2021]

Cannabigerol (CBG), a compound derived from Cannabis sativa L., shows promising therapeutic potential due to its wide range of biological activities, including anti-inflammatory, antibacterial, and neuromodulatory effects.

CBG's ability to interact with G-protein-coupled receptors suggests it could be useful in treating various diseases that require complex pharmacotherapy, making it a candidate for future therapeutic approaches.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

The Origin and Biomedical Relevance of Cannabigerol. Jastrząb, A., Jarocka-Karpowicz, I., Skrzydlewska, E.[2022]

Citations

1. nature.com nature.com/articles/s41598-024-66879-0

Acute effects of cannabigerol on anxiety, stress, and mood Our prior survey study showed that over 30% of CBG users were self-medicating for depression and 80% reported CBG is more effective than ...

2. clinicaltrials.gov clinicaltrials.gov/study/NCT06638996

Acute Psychological and Physiological Effects of ... The purpose of this study is to examine the acute effects of cannabigerol (CBG) on various psychological (e.g., anxiety, stress, mood, memory, impairment, ...

3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC11597810/

Cannabigerol (CBG): A Comprehensive Review of Its ... CBG may help reduce neuroinflammation, which is associated with various neurodegenerative conditions, such as Alzheimer's disease, Parkinson's ...

4. sciencedirect.com sciencedirect.com/science/article/pii/S2405844024159695

Behavioral effects of two cannabidiol and cannabigerol- ... These results show that both CBG- and CBG+ formulas produce a significant improvement in learning and memory, measured as short-term working ...

5. news.wsu.edu news.wsu.edu/press-release/2024/07/31/cannabinoid-cbg-reduces-anxiety-and-stress-in-first-human-clinical-trial/

Cannabinoid CBG reduces anxiety and stress in first human ... The research revealed that 20 mg of hemp-derived CBG significantly reduced feelings of anxiety at 20, 45 and 60 minutes after ingestion compared to a placebo.

6. sciencedirect.com sciencedirect.com/science/article/pii/S0022356524257438

The Pharmacological Case for Cannabigerol Studies indicate that CBG may have therapeutic potential in treating neurologic disorders (eg, Huntington disease, Parkinson disease, and multiple sclerosis)

7. webmd.com webmd.com/vitamins/ai/ingredientmono-1602/cannabigerol-cbg

Cannabigerol (Cbg) - Uses, Side Effects, and More Mental Health · Multiple ... When taken by mouth: There isn't enough reliable information to know if cannabigerol is safe or what the side effects might be.