Tranexamic Acid for Hip Fracture
(TAHFT Trial)
Trial Summary
What is the purpose of this trial?
This trial is testing whether giving tranexamic acid (a medicine that helps blood clot) to older patients with hip fractures can reduce the need for blood transfusions. These patients often have other health problems and are at high risk of losing a lot of blood during surgery. By reducing bleeding, the medicine could help avoid complications from blood transfusions. Tranexamic acid (TXA) has been widely used to decrease blood loss and transfusion rates in various orthopedic surgeries, including hip fractures.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the drug tranexamic acid for hip fracture?
Is tranexamic acid safe for use in humans?
Research shows that tranexamic acid has been studied for safety in surgeries like knee and hip replacements, and while it helps reduce blood loss, no single study has been large enough to definitively confirm its safety. However, the existing studies suggest it is generally safe when used in these contexts.36789
How does the drug tranexamic acid differ from other treatments for hip fracture?
Tranexamic acid is unique because it is used to reduce blood loss during surgery by preventing the breakdown of blood clots, and it can be administered in various ways, such as intravenously or topically, to target the bleeding site directly. This approach is different from other treatments that may not focus specifically on controlling surgical bleeding.2461011
Research Team
Gregory Tocks, DO
Principal Investigator
Penn Medicine / Lancaster General Hospital
Eligibility Criteria
This trial is for people aged 65 or older who have a hip fracture in specific areas and need surgery like hemiarthroplasty, total hip replacement, or certain types of fixation. It's not for those with clotting disorders, recent strokes, heart attacks, deep vein thrombosis/pulmonary emboli, or allergies to Tranexamic Acid.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive intravenous tranexamic acid or placebo prior to hip fracture surgery
Post-operative Monitoring
Participants are monitored for acute post-operative transfusions and complications
Follow-up
Participants are monitored for safety and effectiveness after treatment, including complications and mortality
Treatment Details
Interventions
- Placebo
- Tranexamic Acid Injectable Solution
Find a Clinic Near You
Who Is Running the Clinical Trial?
Lancaster General Hospital
Lead Sponsor