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Social Modeling Interventions for Enhancing Placebo Effect
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Waitlist Available
Led By Tor D Wager, PhD
Research Sponsored by Trustees of Dartmouth College
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Fluent or native speakers of English
No current psychiatric or major neurological diagnosis
Timeline
Screening 3 weeks
Treatment Varies
Follow Up daily for: 2 weeks before scan, 2 weeks after last scan. weekly for 1 year after last session.
Awards & highlights
Study Summary
This trial is studying how well two different methods of enhancing the placebo effect work, using brain scans to measure the results.
Who is the study for?
This trial is for English-speaking individuals without psychiatric/neurological disorders, substance abuse history, or pathological pain. They must be able to perform tasks and undergo fMRI scans, not have metal implants, and abstain from alcohol/substances before the study.Check my eligibility
What is being tested?
The study examines how social modeling (observing treatment outcomes in others) and personal treatment experiences affect placebo effects on pain relief. Participants are divided into four groups to observe these effects using behavioral tests and fMRI scans over three months.See study design
What are the potential side effects?
Since this trial focuses on placebo effects through non-invasive methods like observation and experience without actual drugs involved, there are no direct side effects from interventions typically associated with medication.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am a fluent or native English speaker.
Select...
I do not have any major psychiatric or neurological conditions.
Select...
I don't have ongoing severe pain or neurological disorders.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ daily for: 2 weeks before scan, 2 weeks after last scan. weekly for 1 year after last session.
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~daily for: 2 weeks before scan, 2 weeks after last scan. weekly for 1 year after last session.
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Brain: signature responses to pain and aversive images
Intervention effects on aversive image ratings
Intervention effects on pain ratings
Secondary outcome measures
CliexaEase App ratings
Heart rate
Interpersonal Reactivity Index
+2 moreTrial Design
4Treatment groups
Experimental Treatment
Group I: Observed Success - Experienced SuccessExperimental Treatment2 Interventions
This participant group (N=30) will witness a successful placebo during the "observation phase" (i.e. the demonstrator will display reduced pain expressions after receiving the cream) and experience a successful placebo during the "experience phase" (i.e. the experimenter will reduce the intensity of the pain stimuli after applying the cream).
Group II: Observed Success - Experienced FailureExperimental Treatment2 Interventions
This participant group (N=30) will witness a successful placebo during the "observation phase" (i.e. the demonstrator will not display reduced pain expressions after receiving the cream) and experience a failed placebo during the "experience phase" (i.e. the experimenter will not reduce the intensity of the pain stimuli after applying the cream).
Group III: Observed Failure - Experienced SuccessExperimental Treatment2 Interventions
This participant group (N=30) will witness a successful placebo during the "observation phase" (i.e. the demonstrator will display reduced pain expressions after receiving the cream) and experience a successful placebo during the "experience phase" (i.e. the experimenter will reduce the intensity of the pain stimuli after applying the cream).
Group IV: Observed Failure - Experienced FailureExperimental Treatment2 Interventions
This participant group (N=30) will witness a failed placebo during the "observation phase" (i.e. the demonstrator will not display reduced pain expressions after receiving the cream) and experience a failed placebo during the "experience phase" (i.e. the experimenter will not reduce the intensity of the pain stimuli after applying the cream).
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Who is running the clinical trial?
Trustees of Dartmouth CollegeLead Sponsor
23 Previous Clinical Trials
10,565 Total Patients Enrolled
2 Trials studying Pain
210 Patients Enrolled for Pain
Tor D Wager, PhDPrincipal InvestigatorDartmouth College
5 Previous Clinical Trials
413 Total Patients Enrolled
2 Trials studying Pain
210 Patients Enrolled for Pain
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I can read and cooperate with an fMRI exam.I have metal in my body or have worked with metal fragments.You were born with a brain condition like cerebral palsy.I have a neuroendocrine disorder like Cushing's disease.I have been diagnosed with chronic fatigue syndrome.I have taken antipsychotics, isoniazid, or certain blood pressure medicines.I have a seizure disorder.My blood pressure is not stable.I have a tumor or mass lesion.I have a condition related to inflammation of the blood vessels in my brain, or an autoimmune disease.I have or had cancer.I haven't taken antidepressants, mood stabilizers, steroids, or opiates in the last month.I have a condition like multiple sclerosis affecting my brain or spinal cord.You have a history of using drugs or being addicted to them.You currently have or have had a mental health condition in the past.I am a fluent or native English speaker.I do not have a brain infection.My thyroid condition is not being treated.I have not had a heart attack or severe heart disease in the last two years.I do not have any major psychiatric or neurological conditions.You have a condition called dementia.I have a movement disorder that is not familial tremor.You are afraid of being in small or enclosed spaces.I am currently experiencing pain.I suffer from long-term pain.I have had a head injury that made me lose consciousness.I have had a stroke or mini-strokes before.You haven't consumed alcohol or used any drugs for the past 48 hours.I don't have ongoing severe pain or neurological disorders.
Research Study Groups:
This trial has the following groups:- Group 1: Observed Failure - Experienced Success
- Group 2: Observed Success - Experienced Success
- Group 3: Observed Failure - Experienced Failure
- Group 4: Observed Success - Experienced Failure
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What aims are researchers attempting to achieve with this trial?
"This trial is primarily monitoring the brain's signature responses to aversive images and pain. Secondary outcomes include voxel-wise maps of participant group comparisons, CliexaEase App ratings for feelings such as happiness, sadness, fear or stress intensity at bodily locations, and heart rate during the task."
Answered by AI
Will elderly individuals be considered for inclusion in this experiment?
"According to the parameters of this clinical trial, the minimum age for participation is 18 and those above 55 years old are discluded."
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Am I a viable candidate to join this clinical research project?
"To qualify for participation in this trial, applicants must demonstrate a placebo response and be between 18-55 years of age. Approximately 120 individuals are needed to complete the study."
Answered by AI
Are there any vacancies remaining for participants in this clinical trial?
"As per clinicaltrials.gov, this research has concluded its recruitment phase as of October 25th 2022 after having been first posted on the 1st of October 2023. However, 346 other trials are currently seeking participants."
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