Cerebral Open Flow Microperfusion for Brain Tumor
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a new method to deliver treatment directly to the brain during surgery, assessing its safety and feasibility. It aims to assist patients with brain tumors called gliomas or those requiring surgery for epilepsy. The treatment, known as Cerebral Open Flow Microperfusion, uses specialized equipment to deliver medication directly into the brain during surgery. Suitable candidates have been diagnosed with gliomas or need surgery for epilepsy and plan to undergo surgery at Mayo Clinic in Rochester, MN. As an unphased trial, this study provides a unique opportunity to contribute to groundbreaking research and potentially benefit from innovative treatment methods.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that this microperfusion technique is safe for brain surgery?
Research has shown that cerebral open flow microperfusion is a method used to study how substances enter the brain. This technique improves the delivery and monitoring of medications in brain tissues. Studies have found that devices like OFM catheters and pumps are designed for safe use in the brain. These tools help researchers understand drug interactions with brain tumors or other brain conditions. Although specific data on harmful effects is lacking, the technology is intended to be safe for use in humans during brain surgery.12345
Why are researchers excited about this trial?
Cerebral Open Flow Microperfusion is unique because it delivers treatments directly to the brain tissue affected by tumors, bypassing the blood-brain barrier which often limits the effectiveness of standard therapies like chemotherapy and radiation. This technique allows for a more concentrated and targeted delivery of therapeutic agents, potentially reducing side effects and increasing efficacy. Researchers are excited about this approach because it provides a new way to directly address brain tumors, potentially leading to better outcomes for patients with fewer systemic effects.
What evidence suggests that cerebral open flow microperfusion is effective for brain tumors?
Research has shown that cerebral open flow microperfusion (cOFM) offers a promising method to study brain tumors. This technique enables scientists to safely access and examine the tumor area without causing damage. It tracks how drugs move from the bloodstream into the tumor, providing important insights for treatment. Early results suggest that cOFM could enhance understanding and management of aggressive brain tumors like glioblastoma. While the main focus remains on ensuring safety and practicality, the potential for improved treatment monitoring makes cOFM an exciting development in brain tumor research.13678
Who Is on the Research Team?
Terence Burns, MD
Principal Investigator
Mayo Clinic
Are You a Good Fit for This Trial?
This trial is for individuals undergoing neurosurgical resection of brain tissue due to epilepsy or glioma, such as a glioblastoma. Specific details on eligibility criteria are not provided, so participants should consult with the study team to determine if they qualify.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Intra-operative Microperfusion
Evaluation of safety and feasibility of intra-operative microperfusion during planned neurosurgical resection
Follow-up
Participants are monitored for safety and effectiveness after treatment, focusing on adverse events and sample collection
What Are the Treatments Tested in This Trial?
Interventions
- Cerebral Open Flow Microperfusion
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor
National Cancer Institute (NCI)
Collaborator