All > Mesothelioma

Radical Pleurectomy for Mesothelioma

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Abramson Cancer Center of the University of Pennsylvania, Philadelphia, PAMesotheliomaRadical Pleurectomy - Procedure
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This trial is testing whether adding a light-based therapy to surgery and chemo can improve survival in people with a certain type of lung cancer.

Eligible Conditions
  • Mesothelioma

Treatment Effectiveness

Effectiveness Progress

1 of 3

Similar Trials

1
Light Dosimetry for Intranoperative Therapy
1
Porfimer Sodium
1
Genomically Guided Radiation Therapy

Study Objectives

1 Primary · 3 Secondary · Reporting Duration: 4 years

4 years
Local Control
Progression-free survival months
Receipt of Pembrolizumab
Survival months

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Similar Trials

1
Light Dosimetry for Intranoperative Therapy
1
Porfimer Sodium
2
Genomically Guided Radiation Therapy

Trial Design

2 Treatment Groups

patients who undergo RP alone
1 of 2
patients who undergo RP plus photofrin-based PDT
1 of 2

Experimental Treatment

102 Total Participants · 2 Treatment Groups

Primary Treatment: Radical Pleurectomy · No Placebo Group · Phase 2

patients who undergo RP aloneExperimental Group · 2 Interventions: Radical Pleurectomy, Chemotherapy · Intervention Types: Procedure, Radiation
patients who undergo RP plus photofrin-based PDTExperimental Group · 4 Interventions: Photodynamic Therapy, Radical Pleurectomy, Chemotherapy, Photofrin 2.0 mg/kg · Intervention Types: Radiation, Procedure, Radiation, Drug
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Photodynamic Therapy
2014
Completed Phase 4
~410
Chemotherapy
2003
Completed Phase 4
~2740

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 4 years

Who is running the clinical trial?

Abramson Cancer Center of the University of PennsylvaniaLead Sponsor
359 Previous Clinical Trials
105,746 Total Patients Enrolled
5 Trials studying Mesothelioma
87 Patients Enrolled for Mesothelioma
Keith Cengel, MD, PhDPrincipal InvestigatorAbramson Cancer Center of the University of Pennsylvania
3 Previous Clinical Trials
9 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 8 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
The disease is only present in one side of the chest.
References

Frequently Asked Questions

Has the FDA officially validated Radical Pleurectomy as a treatment option?

"We appraised the safety of radical pleurectomy to be 2, owing to its Phase 2 status with limited data attesting to efficacy but some evidence of security." - Anonymous Online Contributor

Unverified Answer

How many participants is this trial limited to?

"Affirmative. Evidence on clinicaltrials.gov reveals that this investigation is actively enrolling patients, with the first posting occuring on May 1st 2014 and a recent update being made July 25th 2022. 102 participants are desired between two distinct medical centres." - Anonymous Online Contributor

Unverified Answer

Is it feasible for individuals to join this trial at present?

"Affirmative. Clinicaltrials.gov provides evidence that this medical experiment, first posted on May 1st 2014, is in need of participants to move forward with the trial. The study intends to recruit 102 individuals from 2 different locations." - Anonymous Online Contributor

Unverified Answer

What former investigations have been conducted on Radical Pleurectomy?

"Currently, the landscape of Radical Pleurectomy clinical trials are in Phase 1 and 2. There is a concentration of studies running out of Philadelphia, Pennsylvania but 6 medical sites across the United States have active investigations into this procedure." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

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